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Title Animal models in eye research [electronic resource] / edited by Pangiotis A. Tsonis
Imprint San Diego : Academic Press, 2008
book jacket
Edition 1st ed
Descript xiv, 215 p. : ill. (some col.) ; 28 cm
Note Includes bibliographical references and index
An introductory short chapter on the different types of eyes, stressing possible common molecular machinery (mono vs polyphyletic). -- Eye diversity in the animal Kingdom -- Photosensitivity: Melanopsin, opsins -- Cyanobacteria, protozoa: photoreception, rhodopsin -- Platynereis: as a model for lochotrophozoa -- Drosophila: Superb system for genetics, genetic manipulation. -- Planaria: As a model for invertebrate eye regeneration with emphasis on stem cells. -- Fish/cavefish: As a model for retina regeneration and lens development. Zebrafish is accessible for genetic manipulation by morpholinos, medaka accessible for genetic studies. -- Xenopus: As a model for retina (via progenitor cells) and lens regeneration (by transdifferentiation from the cornea). Also an important model for transgenic studies in amphibia. -- Newt: As a model for retina and lens regeneration in adult vertebrates by transdifferentiation. Xenopus and Newt could be combined as a chapter on amphibia. -- Chick: Excellent system for retina regeneration (both transdifferentiation and stem cells) as well for lens and retina development. RCAS transgenesis is an important asset of this system. -- Mouse: Knock-out and transgenesis technologies make this animal the best mammal to study eye development. -- Rabbit: Model for cataract surgery. -- A chapter could be devoted to animals where we see recruitment of crystallins to perform other roles -- Animal models for physiology of the eye
Anatomical and functional diversity of animal eyes -- The simplest eyes: rhodopsin-mediated phototaxis reception in microorganisms -- The planarian eye: a simple and plastic system with great regenerative capacity -- Development of the Drosophila melanogaster eye: from precursor specification to terminal differentiation -- The Antarctic toothfish: a new model system for eye lens biology -- Xenopus, an ideal vertebrate system for studies of eye development and regeneration -- The newt as a model for eye regeneration -- The chick as a model for retina development and regeneration -- Eye development using mouse genetics -- Epithelial explants and their application to study developmental processes in the lens -- Mouse models of the cornea and lens: understanding ocular disease -- Deciphering irradiance detection in the mammalian retina -- The rabbit in cataract/IOL surgery -- The primate in cataract/IOL surgery
The eye is a complex sensory organ, which enables visual perception of the world. Thus the eye has several tissues that do different tasks. One of the most basic aspects of eye function is the sensitivity of cells to light and its transduction though the optic nerve to the brain. Different organisms use different ways to achieve these tasks. In this sense, eye function becomes a very important evolutionary aspect as well. This book presents the different animal models that are commonly used for eye research and their uniqueness in evaluating different aspects of eye development, evolution, physiology and disease. * Presents information on the major animal models used in eye research including invertebrates and vertebrates * Provides researchers with information needed to choose between model organisms * Includes an introductory chapter on the different types of eyes, stressing possible common molecular machinery
Electronic reproduction. Amsterdam : Elsevier Science & Technology, 2008. Mode of access: World Wide Web. System requirements: Web browser. Title from title screen (viewed on Dec. 9, 2008). Access may be restricted to users at subscribing institutions
Link Original 9780123741691 0123741696 (OCoLC)229026137
Subject Eye -- Physiology
Physiology, Comparative
Anatomy, Comparative
Animal Structures
Ocular Physiology
Physiology, Comparative
Anatomy, Comparative
Electronic books. local
Alt Author Tsonis, Panagiotis A. Editor.
ScienceDirect (Online service)
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