Part I Starting Situation -- Challenges in Engineering for Software-Intensive Embedded Systems -- Requirements from the Application Domains -- Part II The SPES Modeling Framework -- Introduction to the SPES Modeling Framework -- Requirements Viewpoint -- Functional Viewpoint -- Logical Viewpoint -- Technical Viewpoint -- Modeling Quality Aspects: Safety -- Modeling Quality Aspects: Real-Time -- Part III Application and Evaluation of the SPES Modeling Framework -- Overview of the SPES Evaluation Strategy -- Application and Evaluation in the Automation Domain -- Application and Evaluation in the Automotive Domain -- Application and Evaluation in the Avionics Domain -- Application and Evaluation in the Energy Domain -- Application and Evaluation in the Healthcare Domain -- Evaluation Summary -- Part IV Impact of the SPES Modeling Framework -- Lessons Learned -- Outlook