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Title Gene therapy of the central nervous system : from bench to bedside / Michael G. Kaplitt, Matthew J. During
Imprint Boston : Academic Press, c2006
book jacket
 Life Sci. LIB  WL300 G326 2006    AVAILABLE    30150100266540
Descript xiv, 355 p. : ill (some col.) ; 29 cm
Note Design and optimization of expression cassettes including promoter choice and regulatory elements -- Identification of novel adeno-associated virus serotypes for use as vectors -- HSV amplicon vectors for gene delivery to the nervous system -- Influence of the immune system on central nervous system gene transfer -- Targeted induction of endogenous neural stem and progenitor cells : a new strategy for gene therapy of neurological disease -- Neurosurgical targeting, delivery, and infusion of gene therapy agents in the brain -- Gene transfer for neurological disease : agencies, policies, and process -- Gene therapy for Parkinson's disease -- Nonhuman primate models for testing gene therapy for neurodegenerative disorders -- Delivery of molecular therapeutics into the CNS and their distribution within the brain -- Gene therapy for CNS diseases using intrabodies -- Gene therapy for epilepsy -- Genetic manipulation of learning and memory -- Psychiatric applications of viral vectors -- Use of viral vectors to influence behavior -- Herpes simplex vector mediated gene transfer to the peripheral nervous system for the treatment of polyneuropathy and chronic pain -- Characterization of pain receptors in the spinal cord using a viral vector for spatial-temporal gene targeting -- Viral vector mediated gene therapy of pain -- VEGF, an angiogenic factor with neurotrophic activity, useful for treatment of ALS? -- Viral vector axonal uptake and retrograde transport : mechanisms and applications -- Gene therapy for spinal cord injury -- Prodrug-activation gene therapy -- Clinical trials of gene therapy for Canavan disease -- Gene therapy for the late infantile form of batten disease -- Molecular imaging of gene therapy for neurogenetic diseases
Includes bibliographical references and index
Subject Central nervous system -- Diseases -- Gene therapy
Genetic vectors
Genetic Vectors
Central Nervous System Diseases -- genetics
Central Nervous System Diseases -- therapy
Central Nervous System -- physiology
Genes, Viral -- genetics
Gene Expression Regulation, Viral
Gene Therapy
Humans Central nervous system Diseases
Alt Author Kaplitt, Michael G
During, Matthew J
Alt Title Gene therapy in the central nervous system : from bench to bedside
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