| Descript |
xiv, 355 p. : ill (some col.) ; 29 cm |
| Note |
Design and optimization of expression cassettes including promoter choice and regulatory elements -- Identification of novel adeno-associated virus serotypes for use as vectors -- HSV amplicon vectors for gene delivery to the nervous system -- Influence of the immune system on central nervous system gene transfer -- Targeted induction of endogenous neural stem and progenitor cells : a new strategy for gene therapy of neurological disease -- Neurosurgical targeting, delivery, and infusion of gene therapy agents in the brain -- Gene transfer for neurological disease : agencies, policies, and process -- Gene therapy for Parkinson's disease -- Nonhuman primate models for testing gene therapy for neurodegenerative disorders -- Delivery of molecular therapeutics into the CNS and their distribution within the brain -- Gene therapy for CNS diseases using intrabodies -- Gene therapy for epilepsy -- Genetic manipulation of learning and memory -- Psychiatric applications of viral vectors -- Use of viral vectors to influence behavior -- Herpes simplex vector mediated gene transfer to the peripheral nervous system for the treatment of polyneuropathy and chronic pain -- Characterization of pain receptors in the spinal cord using a viral vector for spatial-temporal gene targeting -- Viral vector mediated gene therapy of pain -- VEGF, an angiogenic factor with neurotrophic activity, useful for treatment of ALS? -- Viral vector axonal uptake and retrograde transport : mechanisms and applications -- Gene therapy for spinal cord injury -- Prodrug-activation gene therapy -- Clinical trials of gene therapy for Canavan disease -- Gene therapy for the late infantile form of batten disease -- Molecular imaging of gene therapy for neurogenetic diseases |
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Includes bibliographical references and index |
| Subject |
Central nervous system -- Diseases -- Gene therapy
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Genetic vectors
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Viruses
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Genetic Vectors
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Central Nervous System Diseases -- genetics
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Central Nervous System Diseases -- therapy
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Central Nervous System -- physiology
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Genes, Viral -- genetics
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Gene Expression Regulation, Viral
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Gene Therapy
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Humans Central nervous system Diseases
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| Alt Author |
Kaplitt, Michael G
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During, Matthew J
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| Alt Title |
Gene therapy in the central nervous system : from bench to bedside |
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