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作者 Rudin, M. (Markus), 1953-
書名 Molecular imaging [electronic resource] : basic principles and applications in biomedical research / by Markus Rudin
出版項 [Hackensack] New Jersey : World Scientific, 2013
國際標準書號 9781848168572 (electronic bk.)
1848168578 (electronic bk.)
9781783263172 (electronic bk.)
9781848168565
184816856X
book jacket
版本 2nd ed
說明 1 online resource (xxiv, 593 p.)
附註 Includes bibliographical references and index
1. Introduction. 1.1. Biomedical research: elucidating molecular mechanisms of disease. 1.2. The drug discovery process: from target validation to proof-of-concept in man. 1.3. Imaging in biomedical research. 1.4. Summary -- 2. Imaging techniques. 2.1. X-ray computed tomography (CT). 2.2. Magnetic resonance imaging (MRI). 2.3. Nuclear imaging: gamma scintigraphy, single photon emission computerized tomography (SPECT). 2.4. Positron emission tomography (PET). 2.5. Optical imaging. 2.6. Ultrasound imaging. 2.7. Optoacoustic imaging. 2.8. Hybrid techniques. 2.9. Summary -- 3. Molecular reporter systems. 3.1. X-ray contrast agents. 3.2. MRI contrast agents. 3.3. SPECT radioisotopes. 3.4. PET radioisotopes. 3.5. Optical probes: fluorescence and bioluminescence probes. 3.6. Contrast agents for ultrasound imaging. 3.7. Summary -- 4. Design of molecular imaging probes. 4.1. Design of target-specific probes. 4.2. Probe delivery, cell penetration. 4.3. Signal amplification. 4.4. Physiological amplification. 4.5. Summary -- 5. Drug imaging. 5.1. Drug biodistribution and pharmacokinetics. 5.2. Receptor occupancy studies. 5.3. Summary -- 6. Imaging gene expression. 6.1. Visualizing transcription: targeting messenger RNA using labeled antisense oligo-nucleotides. 6.2. Direct target imaging using receptor-specific ligands. 6.3. Reporter genes. 6.4. Summary -- 7. Imaging the function of gene products. 7.1. Imaging of signal transduction pathways/protein-protein interaction. 7.2. Apoptosis. 7.3. Imaging hypoxia signaling. 7.4. Metabolic/physiological response to receptor activation. 7.5. Summary -- 8. Monitoring of cell migration. 8.1. Introduction. 8.2. Inflammatory cells. 8.3. Stem and progenitor cells. 8.4. Labeled tumor cells/metastasis formation. 8.5. Infectious diseases, gene marking of pathogens. 8.6. Summary
The area of molecular imaging has matured over the past decade and is still growing rapidly. Many concepts developed for molecular biology and cellular imaging have been successfully translated to in vivo imaging of intact organisms. Molecular imaging enables the study of processes at a molecular level in their full biological context. Due to the high specificity of the molecular readouts the approach bears a high potential for diagnostics. It is fair to say that molecular imaging has become an indispensable tool for biomedical research and drug discovery and development today. This volume familiarizes the reader with the concepts of imaging and molecular imaging in particular. Basic principles of imaging technologies, reporter moieties for the various imaging modalities, and the design of targeted probes are described in the first part. The second part illustrates how these tools can be used to visualize relevant molecular events in the living organism. Topics covered include the studies of the biodistribution of reporter probes and drugs, visualization of the expression of biomolecules such as receptors and enzymes, and how imaging can be used for analyzing consequences of the interaction of a ligand or a drug with its molecular target by visualizing signal transduction, or assessing the metabolic, physiological, or structural response of the organism studied. The final chapter deals with visualization of cell migration, for example in the context of cell therapies. The second edition covers novel developments over recent years, in particular regarding imaging technologies (hybrid techniques) and novel reporter concepts. Novel biomedical applications have been included, where appropriate. All the chapters have been thoroughly reworked and the artwork updated
Description based on print version record
主題 Molecular probes
Diagnostic imaging
Imaging systems in medicine
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