MARC 主機 00000nam  2200349   4500 
001    AAI3231254 
005    20101019084752.5 
008    101019s2006    ||||||||||||||||| ||eng d 
020    9780542852084 
035    (UMI)AAI3231254 
040    UMI|cUMI 
100 1  Branchaud, Edward A 
245 12 A control system for positioning recording electrodes to 
       isolate neurons in extracellular recordings 
300    100 p 
500    Source: Dissertation Abstracts International, Volume: 67-
       08, Section: B, page: 4655 
500    Adviser:  Joel W. Burdick 
502    Thesis (Ph.D.)--California Institute of Technology, 2006 
520    This thesis presents an algorithm that autonomously 
       positions recording electrodes inside cortical tissue so 
       as to isolate and then maintain optimal extracellular 
       signal recording quality without human intervention. The 
       algorithm is used to improve the quality and efficiency of
       acute (daily insertion) recordings that are needed for 
       basic research in neurophysiology. It also offers the 
       potential to increase the longevity and quality of chronic
       (long-term implant) recordings by controlling an emerging 
       class of chronic arrays in which the electrodes can be 
       continually repositioned after implantation 
520    The challenges encountered in attempting to isolate 
       neurons are studied. A solution is proposed in which a 
       finite state machine oversees a number of signal 
       processing steps, computes various metrics of the 
       recording quality and issues commands to move the 
       electrode close to neurons without causing them damage. A 
       number of metrics of the quality of neuron isolation are 
520    The algorithm has been used to control a number of 
       commercial microdrive systems, including a single-
       electrode FHC microdrive and multielectrode microdrives 
       from Thomas Recording and NAN, as well as a novel 
       miniature microdrive. The autonomous positioning software 
       is used by several neuroscientists to perform basic 
       neurophysiology research. Analysis of the system's 
       performance in isolating neurons is included 
590    School code: 0037 
650  4 Biology, Neuroscience 
650  4 Engineering, Mechanical 
690    0317 
690    0548 
710 2  California Institute of Technology 
773 0  |tDissertation Abstracts International|g67-08B 
856 40 |u