MARC 主機 00000nam a2200433 a 4500 
001    978-3-319-46112-0 
003    DE-He213 
005    20161104135630.0 
006    m        d         
007    cr nn 008maaau 
008    161104s2017    gw      s         0 eng d 
020    9783319461120|q(electronic bk.) 
020    9783319461113|q(paper) 
024 7  10.1007/978-3-319-46112-0|2doi 
040    GP|cGP 
041 0  eng 
050  4 RM666.E548 
082 04 615.35|223 
245 00 Zinc enzyme inhibitors|h[electronic resource] :|benzymes 
       from microorganisms /|cedited by Claudiu T. Supuran, 
       Clemente Capasso 
260    Cham :|bSpringer International Publishing :|bImprint: 
300    ix, 156 p. :|bill., digital ;|c24 cm 
490 1  Topics in medicinal chemistry,|x1862-2461 ;|v22 
505 0  An Elusive Task: A Clinically Useful Inhibitor of Metallo-
       β-Lactamases -- Inhibitors of Histidinol Dehydrogenase -- 
       Botulinum Neurotoxin, Tetanus Toxin, and Anthrax Lethal 
       Factor Countermeasures -- Inhibition and Activity 
       Regulation of Bacterial Collagenases -- Fungal Carbonic 
       Anhydrases and Their Inhibition -- Protozoan Carbonic 
       Anhydrases -- Bacterial Carbonic Anhydrases 
520    Medicinal chemistry is both science and art. The science 
       of medicinal chemistry offers mankind one of its best 
       hopes for improving the quality of life. The art of 
       medicinal chemistry continues to challenge its 
       practitioners with the need for both intuition and 
       experience to discover new drugs. Hence sharing the 
       experience of drug research is uniquely beneficial to the 
       field of medicinal chemistry. Drug research requires 
       interdisciplinary team-work at the interface between 
       chemistry, biology and medicine. Therefore, the topic-
       related series Topics in Medicinal Chemistry covers all 
       relevant aspects of drug research, e.g. pathobiochemistry 
       of diseases, identification and validation of (emerging) 
       drug targets, structural biology, drugability of targets, 
       drug design approaches, chemogenomics, synthetic chemistry
       including combinatorial methods, bioorganic chemistry, 
       natural compounds, high-throughput screening, 
       pharmacological in vitro and in vivo investigations, drug-
       receptor interactions on the molecular level, structure-
       activity relationships, drug absorption, distribution, 
       metabolism, elimination, toxicology and pharmacogenomics. 
       In general, special volumes are edited by well known guest
650  0 Zinc enzymes|xInhibitors 
650 14 Chemistry 
650 24 Medicinal Chemistry 
650 24 Enzymology 
650 24 Pharmaceutical Sciences/Technology 
700 1  Supuran, Claudiu T 
700 1  Capasso, Clemente 
710 2  SpringerLink (Online service) 
773 0  |tSpringer eBooks 
830  0 Topics in medicinal chemistry ;|v22 
856 40 |u