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作者 Serhan, Charles N
書名 Fundamentals of Inflammation
出版項 New York : Cambridge University Press, 2010
©2010
國際標準書號 9780511726446 (electronic bk.)
9780521887298
book jacket
說明 1 online resource (489 pages)
text txt rdacontent
computer c rdamedia
online resource cr rdacarrier
附註 Cover -- Half-title -- Title -- Copyright -- Contents -- Contributors -- Preface -- Part I. The Inflammatory Response - an Overview -- 1 Acute and Chronic Inflammation -- Introduction -- The Acute Inflammatory Response -- Regulation of the Acute Inflammatory Response -- The Complement Cascade -- Intercommunications between Inflammatory Cascades and the Coagulation Cascade -- Outcomes of the Acute Inflammatory Response and Disordered Responses -- Functional Consequences of the Acute Inflammatory Response -- Granulomatosis Inflammation -- Chronic Inflammation -- Therapeutic Interventions in Inflammation -- Acknowledgments -- Suggested readings -- 2 Resolution of Acute Inflammation and Wound Healing -- Summary -- Inflammation in Health and Disease -- What is Inflammatory Resolution? -- Soluble Mediators of Inflammation and Resolution -- Controlling Onset -- Onset to Resolution -- Resolving Inflammation -- Getting Rid of Leukocytes -- Macrophages and Resolution - Cellular Players and Homeostasis -- Resolution of Adaptive Immune Responses -- Wound Healing -- Conclusion -- Glossary of Terms -- References -- Suggested Readings -- 3 Links between Innate and Adaptive Immunity -- The innate and adaptive immune systems: definitions, context, and contrasts -- Immune Recognition -- Immune Effectors -- Immune Counter-Regulation -- Relationship between Acute versus Chronic Inflammation and Innate versus Adaptive Immunity -- Regulation of Adaptive Immunity by the Innate Immune System -- Activation of Adaptive Immune responses: T Cells -- Activation of adaptive Immune responses: B Cells -- Immune Class Specification -- Counter-regulation of Adaptive Immune Responses -- Regulation of Innate Immunity by the Adaptive Immune System -- Regulation of Innate Immune Cell Function -- Counter-Regulation of Innate Immune Responses
Tissue-Specific Immunity: Organ-Specific Regulation of Immune Responses -- Suggested Readings -- Part II. Individual Cell Types -- 4A Neutrophils I -- Introduction -- Neutrophil Homeostasis: Myelopoiesis and Destruction -- Neutrophil Anatomy: Morphology and Granules -- Neutrophil Physiology: Activation and Function -- Stimuli and Receptors -- Intracellular Signaling and Second Messengers -- Second Messengers -- Kinases and Kinase Cascades -- The Consequences of Neutrophil Activation: Adhesion, Migration, and Bacterial Killing -- Neutrophil Adhesion and Migration -- Phagocytosis and Bacterial Killing -- Neutrophil Propagation of Inflammation: Production of Inflammatory Mediators -- Arachidonic Acid Metabolites -- Cytokine Production -- References -- Suggested Readings -- 4B Neutrophils II -- Introduction -- Neutrophil Differentiation, Maturation, and Other Generalities -- Neutrophil Microbicidal Mechanisms -- Neutrophil Receptors -- The Role of Neutrophils in Acute Inflammation -- Neutrophil-Derived Cytokines -- Neutrophil Cross Talk With Other Cell Types: Role of Neutrophil-Derived Chemokines -- Neutrophil Apoptosis -- Neutrophils in Human Diseases -- Conclusions -- Suggested Readings -- 5 Mast Cells as Sentinels of Inflammation -- Introduction -- Characteristics of Mast Cells -- Mast Cell Growth and Development -- Role of the Kit Receptor Tyrosine Kinase and Stem Cell Factor -- Accessory Mast Cell Growth Factors -- Transcription Factors and Signaling Molecules -- Mast Cell Activating Receptors -- FcepsilonRI -- Fcgamma Receptors -- Pattern Recognition Receptors -- G-Protein-Coupled Receptors -- Effector Cytokine Receptors -- Inhibitory Receptors -- Immunoglobulin-like and Fc Receptors -- G-Protein-Coupled Receptors -- Mast Cell Pathobiology -- Anaphylaxis -- Asthma -- Mastocytosis -- Other Allergic Conditions -- Atherosclerosis
Roles Implicated by Animal Models -- Suggested Readings -- 6 Basophils -- Introduction -- Identification -- Historical Discovery -- Development -- Phenotypic Characteristics -- Appearance -- Light Microscopy Image -- Electron Microscopy Image -- Cell Surface Markers -- Products of Basophils -- Histamine -- Lipid Mediators -- Cytokines and Chemokines -- Others -- Isolation Techniques -- Positive Selection -- Negative Selection -- Stimuli For Secretion -- FcepsilonRI and ITAM-Linked Receptors -- GPCR -- Formyl Peptide Receptors -- C5a -- Chemokines -- CRTH2 -- Histamine and Leukotriene Receptors -- Cytokines -- Toll-Like Receptors -- Histamine Releasing Factors -- Inhibitory Receptors -- Functional Implications of Basophil Activation -- Tissue Effects of Mediator Release -- Recruitment and Modulation of Other Immune Cells -- Evidence For Roles in Diseases -- Asthma and Rhinitis -- Immunologic Skin Disease -- Anaphylaxis -- Parasitic Infections -- Other Human Diseases -- Guinea Pig and Mouse Models of Disease -- Pharmacological Regulation of Basophil Responses -- Steroids -- LT Receptor Antagonist -- Anti-IgE -- Diagnostic Tests Using Basophils -- Conclusions -- Suggested Readings -- 7 Eosinophils -- Introduction -- Eosinophil Morphology -- Eosinophil Mediators -- Granule Proteins -- Cytokines -- Lipid Mediators -- Eosinophil Development -- Life Cycle -- Eosinophil Migration -- Activation of Eosinophil Degranulation and Mediator Release -- Signal Transduction -- Summary -- Key Points -- Acknowledgments -- References -- Suggested Readings -- 8 Macrophages -- Introduction -- Identification -- Historical Discovery -- Hematopoietic Lineage -- Phenotypic Characteristics -- Cell Surface Markers, Isolation of Macrophages -- Cell Surface Receptors -- Pathogen Recognition Receptors -- Heterogeneity -- Bone Marrow Macrophages -- Alveolar Macrophages
Splenic Macrophages -- Kupffer Cells -- Microglial Cells -- Langerhans Cells -- Mesangial Cells -- Other -- Macrophage Activating Stimuli -- Fc and Complement -- Cytokines -- Chemokines -- Lipoproteins -- Integrins -- Oligosaccharides -- Others -- Macrophage Secretory Products -- Enzymes -- Cytokines -- Complement Components -- Coagulation Factors -- Reactive Oxygen Intermediates -- Arachidonic Acid Intermediates -- Functional Responses of Macrophages -- Phagocytosis of Cell Debris and Invading Organisms -- Chemotaxis -- Antigen Processing and Presentation -- Secretion -- Tumor Cell Control -- Implications of Macrophage Dysregulation -- Evidence For Roles in Diseases -- Arthritis -- Atherosclerosis -- Ibd -- Lung Fibrosis -- Tumor Biology -- Infection -- Pharmacological Regulation of Macrophage Responses -- Steroids -- Anti-TNF Therapy -- Conclusions -- Suggested readings -- 9 Lymphocytes -- Antigen-Presenting Cells -- T CELLS -- T-Cell Development -- T-Cell Receptor Signaling -- The Requirement for Co-Receptors -- Costimulatory Signaling -- Late Costimulation -- Further Differentiation of T Cells -- Effector Function of T Helper Cell Subsets -- Intraepithelial T Cells -- Effector Function of Cytotoxic (Killer) T Lymphocytes -- B CELLS -- B-Cell Development -- B-Cell Receptor Signaling -- The Requirement for Co-receptors -- B-Cell Effector Function -- Natural Killer Cells -- NK Cell Function -- Suggested Readings -- Antigen presentation -- T-cell development -- T-cell receptor signaling -- Costimulatory signaling and late costimulators -- Effector function of T helper cell subsets -- Intraepithelial T cells -- Effector function of cytotoxic (killer) T lymphocytes -- B-cell development -- B-cell receptor signaling -- The requirement for co-receptors -- B-cell effector function -- NK cell function -- References for protein structures
10 Fibroblasts and Stromal Cells -- What is a Stromal Cell? -- Stromal Cell Identity and Microenvironments -- Stromal Cells and Inflammation -- Stromal Cells: In vitro and In vivo -- Embryological Origins of Fibroblasts -- Sources of Tissue Fibroblasts -- Fibroblasts versus Mesenchymal Precursor Cells -- Stromal Cells in Immune Responses -- Stromal Cells as Innate Immune Sentinels -- Signal Transduction Processes -- Stromal Cell-Leukocyte Interactions and Persistent Inflammation -- Recruitment of Inflammatory Infiltrates into the Joint -- Stromal Support for Leukocyte Survival -- Stromal Cell Retention of Leukocytes in Persistent Inflammatory Disorders -- Constitutive Chemokines and Lymphoid Neogenesis -- Multiple Cell-Cell Interactions Involving Fibroblasts -- Summary -- Key Points -- What Is a Stromal Cell? -- Embryological Origins of Fibroblasts -- Stromal Cells in Immune Responses -- Stromal Cell-Leukocyte Interactions and Persistent Inflammation -- Multiple Cell-Cell Interactions Involving Fibroblasts -- Suggested Readings -- 11 Neutrophil-Endothelial Cell Interactions -- Introduction -- Molecular Mechanisms of Pmn Adhesion and Transmigration -- Balance of Pro- and Antiadhesive Forces -- Pmn Influences on Vascular Endothelial Permeability -- Outside-In Signaling Events in Pmn-Endothelial Cell Interactions -- Influence of the Inflammatory Milieu on Pmn-Endothelial Cell Interactions -- Pmn-Endothelial Interaction As a Therapeutic Target -- Conclusions -- References -- Suggested Readings -- PART III. Chemical Mediators -- 12 Lipid Mediators in Acute Inflammation and Resolution: Eicosanoids, PAF, Resolvins, and Protectins -- Introduction -- Biosynthesis of Eicosanoids -- Cyclooxygenases: biosynthesis of Prostanoids -- Prostanoids: the Prostaglandins -- Thromboxane and Prostacyclin -- Lipoxygenase Pathways -- Leukotriene Biosynthesis
Lipoxin Biosynthesis
Provides an introduction to the cell types, chemical mediators, and general mechanisms of the host's first response to invasion
Description based on publisher supplied metadata and other sources
Electronic reproduction. Ann Arbor, Michigan : ProQuest Ebook Central, 2020. Available via World Wide Web. Access may be limited to ProQuest Ebook Central affiliated libraries
鏈接 Print version: Serhan, Charles N. Fundamentals of Inflammation New York : Cambridge University Press,c2010 9780521887298
主題 Inflammation.;Internal medicine
Electronic books
Alt Author Ward, Peter A
Gilroy, Derek W
Ayoub, Samir S
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