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作者 Mayer, Kathryn M
書名 Illuminating biomolecular interactions with localized surface plasmon resonance
國際標準書號 9781124203874
book jacket
說明 97 p
附註 Source: Dissertation Abstracts International, Volume: 71-09, Section: B, page: 5546
Adviser: Jason Hafher
Thesis (Ph.D.)--Rice University, 2010
Noble metal nanoparticles exhibit localized surface plasmon resonance (LSPR), in which incident light causes a collective oscillation of a nanoparticle's free electrons. This phenomenon results in unique optical properties, including enhanced electric fields near the particle surface and an extinction peak at the resonant wavelength. The LSPR extinction peak's location is sensitive to the refractive index of the surrounding medium, especially in the volume closest to the particle surface. This makes plasmonic nanoparticles ideal for biosensing: their refractive index sensitivity can be used to transduce molecular binding signals. A method has been developed to use the optical extinction of films of gold nanorods to track antibody-antigen interactions in real time, resulting in a label-free kinetic immunoassay based on LSPR. Also, this method has been adapted to scattering spectra of single gold bipyramids. The single-particle approach has allowed the label-free detection of single biomolecules with kinetics information. These methods have future applications to both molecular biology and clinical assays
School code: 0187
Host Item Dissertation Abstracts International 71-09B
主題 Chemistry, Physical
Physics, Optics
Biophysics, General
Alt Author Rice University
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