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書名 Precision molecular pathology of prostate cancer / edited by Brian D. Robinson, Juan Miguel Mosquera, Jae Y. Ro, Mukul Divatia
出版項 Cham : Springer International Publishing : Imprint: Springer, 2018
國際標準書號 9783319640969 (electronic bk.)
9783319640945 (paper)
國際標準號碼 10.1007/978-3-319-64096-9 doi
book jacket
說明 1 online resource (xiv, 570 pages) : illustrations, digital ; 24 cm
text txt rdacontent
computer c rdamedia
online resource cr rdacarrier
text file PDF rda
系列 Molecular pathology library, 1935-987X
Molecular pathology library
附註 Part I. General principles -- Approach to patient -- Etiology -- Precursor and pre-invasive lesions of prostate cancer -- Prostatic adenocarcinoma: morphologic spectrum, Gleason scoring, etc -- Genetic susceptibility -- DNA damage repair, BRCA mutations, DNA adducts, SNPs -- Racial differences -- Cancer stem cells Part II. Molecular signatures of primary prostate cancer -- SNPs -- Copy number variation/chromosomal aberration (PTEN deletion, etc.) -- Gene fusions (TMPRSS2:ERG, etc.) -- Gene expression arrays -- Next generation sequencing (point mutations, indels, etc.) -- Epigenetic changes (chromatin remodeling, etc.) -- Proteomics -- Metabolomics -- miRNA and lncRNA Part III. Molecular signatures of advanced prostate cancer -- Lymph node metastasis -- Bone metastasis a -- RANKL, Src kinases, endothelins, bisphosphonates -- Visceral metastasis a -- Role of extracellular matrix, angiogenesis, epithelial-mesenchymal transition (EMT), inflammation -- Castration resistant prostate cancer (CRPC) -- Neuroendocrine prostate cancer (NEPC) Part IV. Key molecular pathways in prostate cancer development and progression -- Androgen receptor in carcinogenesis -- Androgen receptor in progression (CRPC) -- PI3K/Akt/mTOR/PTEN and ERK/MAPK pathways -- Cell cycle regulators (p53, etc.) -- DNA damage repair -- Tyrosine kinase signaling (EGFR, VEGFR, PDGFR, FGFR, IGFR, etc.) -- Cytoskeletal function (microtubules and taxane therapy) Part V. Precision medicine approach: Diagnosis, treatment, prognosis -- Molecular diagnosis -- Molecular imaging -- Molecular prognostic markers/tests -- Molecular targeted therapies -- Towards molecular classification of prostate cancer
Host Item Springer eBooks
主題 Prostate -- Cancer -- Molecular diagnosis
Medicine & Public Health
Pathology
Oncology
Urology
Alt Author Robinson, Brian D., editor
Mosquera, Juan Miguel, editor
Ro, Jae Y., editor
Divatia, Mukul, editor
SpringerLink (Online service)
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