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作者 Provan, Drew
書名 Oxford Handbook of Clinical Haematology
出版項 Oxford : Oxford University Press, 2009
©2009
國際標準書號 9780191551697 (electronic bk.)
9780199227396
book jacket
版本 3rd ed
說明 1 online resource (880 pages)
text txt rdacontent
computer c rdamedia
online resource cr rdacarrier
系列 Oxford Medical Handbooks
Oxford Medical Handbooks
附註 Intro -- Contents -- Acknowledgements -- Contributors -- Symbols and abbreviations -- 1 Clinical approach -- History taking in patients with haematological disease -- Physical examination -- Splenomegaly -- Lymphadenopathy -- Unexplained anaemia -- Patient with elevated haemoglobin -- Elevated WBC -- Reduced WBC -- Elevated platelet count -- Reduced platelet count -- Easy bruising -- Recurrent thromboembolism -- Pathological fracture -- Raised ESR -- Serum or urine paraprotein -- Anaemia in pregnancy -- Thrombocytopenia in pregnancy -- Prolonged bleeding after surgery -- Positive sickle test (HbS solubility test) -- 2 Red cell disorders -- The peripheral blood film in anaemias -- Anaemia in renal disease -- Anaemia in endocrine disease -- Anaemia in joint disease -- Anaemia in gastrointestinal disease -- Anaemia in liver disease -- Iron (Fe) deficiency anaemia -- Vitamin B[sub(12)] deficiency -- Folate deficiency -- Other causes of megaloblastic anaemia -- Anaemia in other deficiency states -- Haemolytic syndromes -- Genetic control of haemoglobin production -- Sickling disorders -- HbS-new therapies -- Sickle cell trait (HbAS) -- Other sickling disorders -- Other haemoglobinopathies -- Unstable haemoglobins -- Thalassaemias -- α thalassaemia -- β thalassaemia -- Other thalassaemias -- Hereditary persistence of fetal haemoglobin -- Hb patterns in haemoglobin disorders -- Non-immune haemolysis -- Hereditary spherocytosis -- Hereditary elliptocytosis -- Glucose-6-phosphate dehydrogenase (G6PD) deficiency -- Pyruvate kinase (PK) deficiency -- Other red cell enzymopathies -- Drug-induced haemolytic anaemia -- Methaemoglobinaemia -- Microangiopathic haemolytic anaemia (MAHA) -- Acanthocytosis -- Autoimmune haemolytic anaemia -- Cold haemagglutinin disease (CHAD) -- Leucoerythroblastic anaemia -- Aplastic anaemia -- Paroxysmal nocturnal haemoglobinuria
Pure red cell aplasia -- Iron (Fe) overload -- Transfusion haemosiderosis -- 3 White blood cell abnormalities -- Neutrophilia -- Neutropenia -- Lymphocytosis and lymphopenia -- Eosinophilia -- Basophilia and basopenia -- Monocytosis and monocytopenia -- Mononucleosis syndromes -- 4 Leukaemia -- Acute myeloblastic leukaemia (AML) -- Acute lymphoblastic leukaemia (ALL) -- Chronic myeloid leukaemia (CML) -- Chronic lymphocytic leukaemia (B-CLL) -- Cell markers in chronic lymphoproliferative disorders -- Prolymphocytic leukaemia (PLL) -- Hairy cell leukaemia and variant -- Splenic marginal zone lymphoma (SMZL) -- Mantle cell lymphoma (MCL) -- Large granular lymphocyte leukaemia (LGLL) -- Adult T-cell leukaemia-lymphoma (ATL) -- Sézary syndrome (SS) -- 5 Lymphoma -- Non-Hodgkin lymphoma (NHL) -- Indolent lymphoma -- Treatment of indolent lymphoma -- Aggressive lymphomas -- Initial treatment of aggressive lymphomas -- CNS lymphoma -- Hodgkin lymphoma (HL, Hodgkin's disease) -- 6 Myelodysplasia -- Myelodysplastic syndromes (MDS) -- Classification -- Clinical features of MDS -- Diagnostic criteria of MDS -- Prognostic factors in MDS -- Clinical variants of MDS -- Management of MDS -- Response criteria -- Myelodysplastic/myeloproliferative diseases (MDS/MPD) -- 7 Myeloproliferative neoplasms (MPNs) -- Myeloproliferative neoplasms (MPNs) -- Pathogenesis of the MPNs -- Polycythaemia vera (PV) -- Natural history of PV -- Management of PV -- Secondary erythrocytosis -- Relative erythrocytosis (RE) -- Idiopathic erythrocytosis (IE) -- Essential thrombocythaemia (ET) -- Reactive thrombocytosis (RT) -- Primary myelofibrosis (PMF) -- Chronic neutrophilic leukaemia (CNL) -- Chronic eosinophilic leukaemia (CEL) and idiopathic hypereosinophilic syndrome (HES) -- Mast cell disease (mastocytosis) -- Systemic mastocytosis (SM) -- MPNs-unclassifiable (MPN-U)
8 Paraproteinaemias -- Paraproteinaemias -- Monoclonal gammopathy of undetermined significance (MGUS) -- Smouldering multiple myeloma (syn. asymptomatic myeloma) -- Multiple myeloma (MM) -- Variant forms of myeloma -- Cryoglobulinaemia -- POEMS syndrome -- Plasmacytoma -- Waldenström macroglobulinaemia (WM) -- Heavy chain disease (HCD) -- AL (1° systemic) amyloidosis -- 9 Haematopoietic stem cell transplantation (SCT) -- Haemopoietic stem cell transplantation (SCT) -- Indications for haemopoietic SCT -- Allogeneic SCT -- Autologous STC -- Investigations for BMT/PBSCT -- Pretransplant investigation of donors -- Bone marrow harvesting -- Peripheral blood stem cell mobilization and harvesting -- Microbiological screening for stem cell cryopreservation -- Stem cell transplant conditioning regimens -- Infusion of cryopreserved stem cells -- Infusion of fresh non-cryopreserved stem cells -- Blood product support for STC -- GvHD prophylaxis -- Acute GvHD -- Chronic GvHD -- Veno-occlusive disease (syn. sinusoidal obstruction syndrome) -- Invasive fungal infections and antifungal therapy -- CMV prophylaxis and treatment -- Post-transplant vaccination programme -- Treatment of relapse post-allogeneic SCT -- Discharge and follow-up -- 10 Haemostasis and thrombosis -- Assessing haemostasis -- The coagulation system -- Laboratory tests -- Platelets -- Bleeding -- Bleeding: laboratory investigations -- Bleeding: therapeutic products -- von Willebrand disease (vWD) -- Haemophilia A and B -- Rare congenital coagulation disorders -- Congenital thrombocytopenias -- Congenital platelet function defects -- Congenital vascular disorders -- Haemorrhagic disease of the newborn -- Thrombocytopenia (acquired) -- Specific thrombocytopenic syndromes -- Disseminated intravascular coagulation (DIC) -- Anticoagulant drug therapy -- Liver disease -- Renal disease
Acquired anticoagulants and inhibitors -- Treatment of spontaneous FVIII inhibitor -- Acquired disorders of platelet function -- Henoch-Schönlein purpura -- Peri-operative bleeding and massive blood loss -- Massive blood loss -- Heparin -- Heparin induced thrombocytopenia/ with thrombosis (HIT/T) -- Oral anticoagulant therapy (warfarin, VKAs) -- Thrombosis -- Risk assessment and thromboprophylaxis -- Example of VTE Risk Assessment -- Heritable thrombophilia -- Acquired thrombophilia -- Thrombotic thrombocytopenic purpura (TTP) -- Haemolytic uraemic syndrome (HUS) -- Heparin-induced thrombocytopenia (HIT) -- 11 Immunodeficiency -- Congenital immunodeficiency syndromes -- Acquired immune deficiencies -- HIV infection and AIDS -- Therapy of HIV infection -- 12 Paediatric haematology -- Blood counts in children -- Red cell transfusion and blood component therapy-special considerations in neonates and children -- Polycythaemia in newborn and childhood -- Neonatal anaemia -- Anaemia of prematurity -- Haemolytic anaemia in the neonate -- Congenital red cell defects -- Acquired red cell defects -- Haemolytic disease of the newborn (HDN) -- Hyperbilirubinaemia -- Neonatal haemostasis -- Neonatal alloimmune thrombocytopenia (NAIT) -- Congenital dyserythropoietic anaemias -- Congenital red cell aplasia -- Acquired red cell aplasia -- Fanconi anaemia (FA) -- Rare congenital marrow failure syndromes -- Neutropenia in childhood -- Disorders of neutrophil function -- Childhood immune (idiopathic) thrombocytopenic purpura (ITP) -- Haemolytic uraemic syndrome (HUS) -- Childhood cancer and malignant blood disorders -- Childhood lymphoblastic leukaemia -- Childhood lymphomas -- Childhood acute myeloid leukaemia (AML) -- Childhood myelodysplastic syndromes and chronic leukaemias -- Histiocytic syndromes -- Haematological effects of systemic disease in children
13 Haematological emergencies -- Septic shock/neutropenic fever -- Transfusion reactions -- Immediate-type hypersensitivity reactions -- Febrile transfusion reactions -- Delayed transfusion reaction -- Bacterial contamination of blood products -- Post-transfusion purpura -- Hypercalcaemia -- Hyperviscosity -- Disseminated intravascular coagulation (DIC) -- Overdosage of thrombolytic therapy -- Heparin overdosage -- Heparin-induced thrombocytopenia (HIT) -- Warfarin overdosage -- Massive blood transfusion -- Paraparesis/spinal collapse -- Leucostasis -- Thrombotic thrombocytopenic purpura -- Sickle crisis -- 14 Supportive care -- Quality of life -- Pain management -- Psychological support -- 15 Protocols and procedures -- Acute leukaemia-investigations -- Platelet storage and administration -- Platelet reactions and refractoriness -- Prophylactic regimen for neutropenic patients -- Guidelines for use of IV antibiotics in neutropenic patients -- Treatment of neutropenic sepsis when source unknown -- Treatment of neutropenic sepsis when source known/suspected -- Prophylaxis for patients treated with purine analogues -- Tumour lysis syndrome (TLS) -- Management of chronic bone marrow failure -- Venepuncture -- Venesection -- Tunnelled central venous catheters -- Bone marrow examination -- Administration of chemotherapy -- Antiemetics for chemotherapy -- Intrathecal chemotherapy -- Management of extravasation -- Specific procedures following extravasation -- Splenectomy -- Plasma exchange (plasmapheresis) -- Leucapheresis -- Anticoagulation therapy-heparin -- Oral anticoagulation -- Management of needlestick injuries -- Chemotherapy protocols: ABVD -- BEACOPP & Escalated BEACOPP -- BEAM -- CHOP 21 & CHOP 14 -- ChlVPP -- CODOX-M/IVAC -- CTD & CTDa -- DHAP ± R -- EPOCH & DA-EPOCH ± R -- ESHAP ± R -- FC ± R -- FMD ± R (FND ± R) -- Hyper-CVAD ± R / MA± R
ICE ± R
The Oxford Handbook of Clinical Haematology continues to provide the essential knowledge needed in modern clinical practice for the diagnosis and management of patients with disorders of the blood. Major advances in the specialty, primarily within the malignant haematology area, have been reflected in this thoroughly revised new edition. Agencies such as NICE have influenced the prescribing of chemotherapeutic and other related drugs, and there have also been updates from theBritish Committee for Standards in Haematology and other guidelines for malignant disease, thrombosis and haemostasis.This Handbook includes the main differential diagnoses and relevant investigations that will help junior doctors to arrive at a definitive diagnosis. The management of the patient is provided in a way that allows the junior to initiate treatment whilst waiting for review of the patient by a senior member of staff. A bestselling Oxford Handbook, this is the indispensable companion for all those caring for patients with blood disorders
Description based on publisher supplied metadata and other sources
Electronic reproduction. Ann Arbor, Michigan : ProQuest Ebook Central, 2020. Available via World Wide Web. Access may be limited to ProQuest Ebook Central affiliated libraries
鏈接 Print version: Provan, Drew Oxford Handbook of Clinical Haematology Oxford : Oxford University Press,c2009 9780199227396
主題 Persuasion (Psychology) -- Computer programs -- Congresses.;Human-computer interaction -- Congresses.;Health promotion -- Computer programs -- Congresses
Electronic books
Alt Author Singer, Charles R J
Baglin, Trevor
Dokal, Inderjeet
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