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作者 Wuang, Shy Chyi
書名 Functionalization of magnetic nanoparticles for bio-applications
國際標準書號 9781109348361
book jacket
說明 156 p
附註 Source: Dissertation Abstracts International, Volume: 70-08, Section: B, page: 5015
Adviser: Stephen Boppart
Thesis (Ph.D.)--University of Illinois at Urbana-Champaign and National University of Singapore (Singapore), 2009
Magnetite nanoparticles were modified to render them suitable for bio-applications, namely drug delivery and hyperthermia, using two different approaches. The first approach is to graft polymers onto the nanoparticles using surface-initiated atom transfer radical polymerization, followed by chemical linking of biomolecules onto the grafted polymers. The monomers used include N-isopropylacrylamide, N-vinylformamide and methacrylic acid while the immobilized biomolecules include heparin, folic acid, doxorubicin and anti-HER2/neu antibodies. It was found that the heparinized nanoparticles could reduce macrophage uptake, and at the same time inhibit plasma clotting. The doxorubicin-bearing nanoparticles were able to release a greater amount of the drug under acidic conditions as opposed to physiological pH, and could potentially serve as drug depots. Particles that were functionalized with anti-HER2/neu antibodies showed a preferential binding to cancer cells and may be useful for imaging purposes
The second approach was to encapsulate these magnetite nanoparticles into polypyrrole nanospheres via emulsion polymerization for potential use as hyperthermia causing agents. The nanospheres were then functionalized with folic acid or herceptin to impart onto them cancer cell-targeting properties. These functionalized nanospheres target cancer cells in vitro and possess good magnetization which is useful for magnetic fluid hyperthermia
School code: 1561
Host Item Dissertation Abstracts International 70-08B
主題 Engineering, Chemical
0542
Alt Author University of Illinois at Urbana-Champaign and National University of Singapore (Singapore)
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