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作者 Blair, Nathaniel Tyler
書名 Contributions of voltage-gated sodium, calcium and potassium currents to the excitability of nociceptive sensory neurons
國際標準書號 0496653946
book jacket
說明 229 p
附註 Source: Dissertation Abstracts International, Volume: 65-01, Section: B, page: 0093
Adviser: Bruce P. Bean
Thesis (Ph.D.)--Harvard University, 2004
In this thesis I have studied how the voltage-gated conductances expressed in nociceptors control various aspects of action potential generation during stimuli of varying duration and frequency. In Chapter 2 I present experiments using the action potential clamp method to measure the TTX-sensitive sodium, TTX-resistant sodium and calcium currents flowing during nociceptor action potentials, and focus on how inactivation shapes the contributions of TTX-sensitive and TTX-resistant sodium channels. The TTX-resistant sodium current contributes the majority of charge transferred during the action potential, and due to its slow and incomplete inactivation, contributes a significant fraction of the inward charge during the action potential shoulder. Chapter 3 describes the role of TTX-resistant sodium current slow inactivation in the adaptation of firing in nociceptive sensory neurons. Although TTX-resistant sodium channels recover from fast inactivation quite quickly, their rapid entry to slow inactivation prevents nociceptors from firing continuously throughout a depolarizing stimulus. Lastly, in Chapter 4 I describe the role of Kv3 and large conductance calcium-activated potassium channels in nociceptor action potential repolarization and in action potential broadening that occurs during repetitive stimulation. These studies will help in understanding the control of nociceptor excitability, and how changes in conductances might contribute to hyperalgesic states
School code: 0084
Host Item Dissertation Abstracts International 65-01B
主題 Biology, Neuroscience
Chemistry, Biochemistry
Alt Author Harvard University
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