MARC 主機 00000cam  2200000 a 4500 
001    22113526 
003    OCoLC 
005    20160511063347.0 
008    900705s1991    mauad    b    001 0 eng   
010    90043581 
020    0878934529 
020    9780878934522 
035    (OCoLC)22113526|z(OCoLC)23942402 
040    DLC|beng|cDLC|dNLM|dAGL|dMUQ|dBAKER|dNLGGC|dBTCTA|dYDXCP
       |dOCLCG|dTULIB|dDNN|dBDX|dGBVCP|dOCLCO|dOCLCF|dFDS|dOCLCQ
       |dAS 
050 00 QH325|b.L65 1991 
060 00 QH 325|bL693f 1991 
082 00 575.1|220 
100 1  Li, Wen-Hsiung,|d1942- 
245 10 Fundamentals of molecular evolution /|cWen-Hsiung Li, Dan 
       Graur 
260    Sunderland, Mass. :|bSinauer Associates,|c©1991 
300    xv, 284 pages :|billustrations, graphs, tables ;|c24 cm 
336    text|btxt|2rdacontent 
337    unmediated|bn|2rdamedia 
338    volume|bnc|2rdacarrier 
504    Includes bibliographical references and index 
505 2  Introduction: What is molecular evolution? -- Gene 
       structure and mutation. DNA sequences ; Gene structure ; 
       Genetic codes ; Mutation ; Problems -- Dynamics of genes 
       in populations. Changes in allele frequencies ; Natural 
       selection ; Random genetic drift ; Effective population 
       size ; Gene substitution ; Genetic polymorphism ; The Neo-
       Darwinian theory and the neutral mutation hypothesis ; 
       Problems -- Evolutionary change in nucleotide sequences. 
       Nucleotide substitution in a DNA sequence ; Number of 
       nucleotide substitutions between two DNA sequences ; 
       Alignment of nucleotide and amino acid sequence ; Indirect
       estimation of the number of nucleotide substitutions ; 
       Problems -- Rates and patterns of nucleotide substitution.
       Rates of nucleotide substitution ; Causes of variation in 
       substitution rates ; A case of positive selection : 
       lysoazyme in cows and langurs ; Molecular clocks ; Rates 
       of substitution in organelle DNA ; Pattern of nucleotide 
       substitution in pseudogenes ; Nonrandom usage of 
       synonymous codons ; Problems 
505 2  Molecular phylogeny. Impact of molecular data on 
       phylogenetic studies ; Phylogenetic trees ; Methods of 
       tree reconstruction ; Phenetics versus cladistics ; 
       Estimation of branch lengths ; Rooting unrooted trees ; 
       Estimation of species-divergence times ; Clades ; 
       Phylogeny of humans and apes ; Endosymbiotic origin of 
       mitochondria and chloroplasts ; Molecular paleontology ; 
       The dusky seaside sparrow : a lesson in conservation 
       biology ; Problems -- Evolution by gene duplication and 
       exon shuffling. Types of DNA duplication ; Domains and 
       exons ; Domain duplication and gene elongation ; Formation
       of gene families and the acquisition of new functions ; 
       Nonfunctionalization of duplicate genes ; Dating gene 
       duplications ; The globin superfamily of genes ; Exon 
       shuffling ; Alternative pathways for producing new 
       functions ; Concerted evolution of multigene families ; 
       Problems -- Evolution by transposition. Transposition and 
       retroposition ; Transposable elements ; Retrosequences ; 
       Effects of transposition on the host genome ; Hybrid 
       dysgenesis ; Transposition and speciation ; Evolutionary 
       dynamics of transposable-element copy number ; Horizontal 
       gene transfer ; Problems -- Genome organization and 
       evolution. C values ; Evolution of genome size in bacteria
       ; Genome size of eukaryotes and the C-value paradox ; The 
       repetitive structure of the eukaryotic genome ; Mechanisms
       for increasing genome size ; Maintenance of nongenic DNA ;
       GC content in bacteria ; Compositional organization of the
       vertebrate genome ; Problems 
650  0 Molecular evolution 
650  2 Biological Evolution 
650  2 Molecular Biology 
650  2 Molecular Sequence Data 
653  0 Molecular evolution 
700 1  Graur, Dan,|d1953- 
776 08 |iOnline version:|aLi, Wen-Hsiung, 1942-|tFundamentals of 
       molecular evolution.|dSunderland, Mass. : Sinauer 
       Associates, ©1991|w(OCoLC)904224865