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作者 Holden, Matthew Alexander
書名 Studies in biological surface science: Microfluidics, photopatterning and artificial bilayers
國際標準書號 0496793317
book jacket
說明 108 p
附註 Source: Dissertation Abstracts International, Volume: 65-05, Section: B, page: 2389
Chair: Paul S. Cremer
Thesis (Ph.D.)--Texas A&M University, 2004
Herein is presented the collective experimental record of research performed in the Laboratory for Biological Surface Science. These investigations are generally classified under the category of bioanalytical surface science and include the following projects. Chapters III and IV describe the creation of a microfluidic device capable of generating fixed arrays of concentration gradients. Experimental results were matched with computational fluid dynamics simulations to predict analyte distributions in these systems. Chapters V and VI demonstrate the discovery and utility of photobleaching fluorophores for micropatterning applications. Bleached fluorophores were found to rapidly attach to electron rich surfaces and this property was used to pattern enzymes inside microfluidic channels in situ. Finally, Chapter VII exhibits a method by which solid supported lipid bilayers can be dried and preserved by specifically bound proteins. The intrinsic property of lateral lipid mobility was maintained during this process and a mechanism by which the protein protects the bilayer was suggested
School code: 0803
DDC
Host Item Dissertation Abstracts International 65-05B
主題 Chemistry, Analytical
0486
Alt Author Texas A&M University
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