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作者 Hiraku, Yusuke
書名 Cancer and Inflammation Mechanisms : Chemical, Biological, and Clinical Aspects
出版項 Somerset : John Wiley & Sons, Incorporated, 2014
©2014
國際標準書號 9781118826676 (electronic bk.)
9781118160305
book jacket
版本 1st ed
說明 1 online resource (409 pages)
text txt rdacontent
computer c rdamedia
online resource cr rdacarrier
附註 Intro -- CANCER AND INFLAMMATION MECHANISMS -- CONTENTS -- CONTRIBUTORS -- PREFACE -- CHAPTER 1 INFECTION, INFLAMMATION, AND CANCER: OVERVIEW -- INFECTION, INFLAMMATION, AND CANCER: POSSIBLE MECHANISMS -- PRODUCTION OF INFLAMMATORY MEDIATORS AND REACTIVE OXIDANTS -- DNA AND PROTEIN DAMAGE BY ROSs AND RNSs -- INFLAMMATION, EPIGENETIC MODIFICATION, AND microRNA -- CONCLUDING REMARKS -- REFERENCES -- CHAPTER 2 STEM CELL THEORY AND INFLAMMATION-RELATED CANCER -- CHRONIC INFLAMMATION AND CANCER -- CANCER STEM CELLS -- CARCINOGENIC FACTORS ARISING FROM CHRONIC INFLAMMATION -- CHRONIC INFLAMMATION AND NORMAL STEM CELL FUNCTION -- INFLAMMATION AND THE DEVELOPMENT AND REGULATION OF CANCER STEM CELLS -- CONCLUDING REMARKS -- REFERENCES -- CHAPTER 3 EPITHELIAL-MESENCHYMAL TRANSITION: A LINK BETWEEN CANCER AND INFLAMMATION -- EMT: A LINK BETWEEN CANCER AND INFLAMMATION -- Q1: HOW ARE EMT-PERMISSIVE, INFLAMMATORY TUMOR MICROENVIRONMENTS CREATED? -- Role of Macrophages -- Role of Myeloid-Derived Suppressor Cells and Neutrophils -- Role of T Cells -- Role of B Cells -- Role of Dendritic Cells -- Q2: WHICH EMT-PROMOTING SIGNALS ARE PROVIDED BY INFLAMMATORY TUMOR MICROENVIRONMENTS? -- Transforming Growth Factor Beta -- Other Cytokines -- Proteases -- Inflammatory Cytokines and Chemokines -- Q3: HOW DO EMT-PROMOTING SIGNALS INFLUENCE THE MIGRATORY BEHAVIOR OF TUMOR CELLS? -- CONCLUSIONS AND FUTURE PROSPECTS -- Acknowledgments -- REFERENCES -- CHAPTER 4 ROLE OF NITRATIVE DNA DAMAGE IN INFLAMMATION-RELATED CARCINOGENESIS -- DNA DAMAGE DURING CHRONIC INFLAMMATION -- LIVER FLUKE-INDUCED CHOLANGIOCARCINOMA -- HPV-INDUCED CERVICAL CANCER -- EBV-INDUCED NASOPHARYNGEAL CARCINOMA -- DNA DAMAGE INDUCED BY ASBESTOS EXPOSURE -- DNA DAMAGE INDUCED BY CARBON NANOTUBE -- SOFT TISSUE TUMORS AND PROGNOSIS OF TUMOR PATIENTS -- CONCLUSIONS AND FUTURE PROSPECTS -- Acknowledgments
REFERENCES -- CHAPTER 5 LIPID PEROXIDATION-DERIVED DNA ADDUCTS AND THE ROLE IN INFLAMMATION-RELATED CARCINOGENESIS -- LPO-DERIVED REACTIVE PRODUCTS CONTRIBUTE TO DNA DAMAGE -- RESULTS AND DISCUSSION -- LPO-induced DNA Damage: Adduct Types and Levels in Humans -- Quantifying Etheno-DNA Adducts in Human Tissues, White Blood Cells, and Urine by Ultrasensitive 32P-Postlabeling and Immunohistochemical Methods -- Etheno-DNA Adducts as Potential Risk Markers for Inflammation-Driven Malignancies -- CONCLUSIONS AND FUTURE PROSPECTS -- Acknowledgments -- REFERENCES -- CHAPTER 6 LEVEL OF INFLAMMATION-RELATED DNA ADDUCTS IN HUMAN TISSUES -- LEVEL OF 4-ONE- AND 4-OHE-DERIVED DNA ADDUCTS IN HUMAN TISSUES -- BIOLOGICAL PROPERTIES OF 4-ONE- AND 4-OHE-DERIVED DNA ADDUCTS -- INFLAMMATION AND FORMATION OF 4-ONE -- CONCLUDING REMARKS -- REFERENCES -- CHAPTER 7 TOLL-LIKE RECEPTORS: ROLE IN INFLAMMATION AND CANCER -- TLRs AND THEIR LIGANDS -- TLR SIGNALING -- MYD88-DEPENDENT SIGNALING PATHWAYS -- TRIF-DEPENDENT SIGNALING PATHWAYS -- INNATE IMMUNE CELLS IN CANCER TISSUES -- TLRs AND TUMOR MICROENVIRONMENT -- TOLL-LIKE RECEPTORS IN CANCER AND TUMOR THERAPY -- ANTITUMOR ACTIVITY OF TLR LIGANDS -- ROLES OF TLRs IN CANCER PROGRESSION -- CURRENT AND FUTURE DEVELOPMENTS -- Acknowledgments -- REFERENCES -- CHAPTER 8 INFLAMMASOMES AND INFLAMMATION -- NOD-LIKE RECEPTORS AND THE INFLAMMASOMES -- THE NLRP3 INFLAMMASOME -- THE IPAF INFLAMMASOME -- THE NLRP1 INFLAMMASOME -- THE NLRP12 INFLAMMASOME -- THE NLRP7 INFLAMMASOME -- THE NLRP6 INFLAMMASOME -- THE AIM2 INFLAMMASOME -- CYTOKINE TARGETS OF THE INFLAMMASOME -- Interleukin-1 -- Interleukin-18 -- INFLAMMASOME DYSREGULATION IN DISEASE -- Hereditary Fever Syndromes -- Neurodegenerative Diseases -- Pulmonary Diseases -- Metabolic Diseases -- Cancer -- CONCLUDING REMARKS -- REFERENCES
CHAPTER 9 ACTIVATION-INDUCED CYTIDINE DEAMINASE: AN INTRINSIC GENOME MODULATOR IN INFLAMMATION-ASSOCIATED CANCER DEVELOPMENT -- PHYSIOLOGICAL ROLE OF ACTIVATION-INDUCED CYTIDINE DEAMINASE -- ABERRANT EXPRESSION OF AID IN INFLAMMATORY TISSUES -- MECHANISMS FOR AID EXRESSION BY H. PYLORI AND HCV CORE PROTEIN -- INDUCTION OF GENOMIC INSTABILITY BY AID -- LESSONS FOR CANCER RESEARCH IN THE STUDY OF AID -- Roles of NF- B in Carcinogenesis -- Different Spectra of Gene Mutations in Different Cancers -- Relationship Between Mutation Induction and Repair Systems -- Importance of Mutation Signature for Prediction of Mutagens -- SUMMARY -- REFERENCES -- CHAPTER 10 MicroRNA AND INFLAMMATION-RELATED CANCER -- BIOGENESIS AND FUNCTION OF miRNAs -- miRNAs AS MEDIATORS OF INFLAMMATION-INDUCED CANCINOGENESIS -- miRNAs INVOLVEMENT IN THE METASTASIS OF INFLAMMATION-RELATED CANCERS -- SINGLE-NUCLEOTIDE POLYMORPHISMS AMONG miRNAs AND INFLAMMATION-RELATED CANCER SUSCEPTIBILITY -- VIRUS-ENCODED miRNAs AND INFLAMMATION-RELATED CANCERS -- FUTURE PROSPECTS -- REFERENCES -- CHAPTER 11 INFLAMMATION AS A NICHE FOR TUMOR PROGRESSION -- INFLAMMATION CONVERTS A PRIMARY TUMOR ENVIRONMENT TO A FAVORABLE SPOT FOR TUMOR PROGRESSION -- INFLAMMATORY CELL COMPONENTS NECESSARY TO ACCELERATE TUMOR PROGRESSION -- INFLAMMATORY CELL-DERIVED FACTORS NECESSARY TO ACCELERATE TUMOR PROGRESSION -- EXPERIMENTAL MODEL OF INFLAMMATION-BASED TUMOR PROGRESSION -- CONCLUSIONS AND FUTURE PROSPECTS -- REFERENCES -- CHAPTER 12 HUMAN PAPILLOMAVIRUS AND CERVICAL CANCER -- SYMPTOMS AND CLASSIFICATION OF CERVICAL CANCER -- HUMAN PAPILLOMAVIRUS AND CERVICAL CARCINOGENESIS -- HPV Infection and Life Cycle -- HPV Oncogenes -- Regulation of Cervical Cancer by HPV Oncogenes -- HPV Oncogenes as Regulators of Tumor-Associated Inflammation -- THERAPEUTIC INTERVENTIONS -- REFERENCES
CHAPTER 13 HEPATITIS VIRUSES AND HEPATOCELLULAR CARCINOMA -- HBV -- The Virus -- Host-Viral Interactions -- The Host Genome -- HCV -- The Virus -- Host-Viral Interactions -- The Host Genome -- ENVIRONMENTAL AND METABOLIC FACTORS AND INTERACTION WITH HBV AND HCV -- CONCLUDING REMARKS -- REFERENCES -- CHAPTER 14 EPSTEIN-BARR VIRUS AND NASOPHARYNGEAL CARCINOMA -- MOLECULAR BIOLOGY OF EBV -- EBV Genome -- Natural History of EBV Infection -- Patterns of Latent Infection -- EBV Latent Gene Function -- EBV AND NPC -- EBV Infection in NP Cells -- EBV and NP Carcinogenesis -- EBV as a Biomarker for NPC -- EBV as a Therapeutic Target for NPC -- REFERENCES -- CHAPTER 15 BARRETT'S ESOPHAGUS AND ESOPHAGEAL CANCER -- HISTOLOGICAL DIAGNOSIS OF BARRETT'S-RELATED DYSPLASIA AND BARRETT'S-ASSOCIATED CANCER -- ROLE OF MOLECULAR PREDICTORS FOR BARRETT'S CARCINOGENESIS -- THE LINK BETWEEN BARRETT'S CARCINOGENESIS AND INFLAMMATION -- INFLAMMATION AND GENETIC ALTERATIONS IN BARRETT'S CARCINOGENESIS -- INFLAMMATION AND EPIGENETIC ALTERATIONS IN BARRETT'S CARCINOGENESIS -- CONCLUDING ASSESSMENT OF INFLAMMATION AND BARRETT'S CARCINOGENESIS -- REFERENCES -- CHAPTER 16 ASBESTOS-INDUCED CHRONIC INFLAMMATION AND CANCER -- ASBESTOS AND ASBESTOS-LIKE FIBERS: OLD AND NEW HAZARDS -- GENES MAY MODULATE THE RISK OF ASBESTOS-RELATED DISEASES -- ASBESTOS, INFLAMMATION, AND CARCINOGENESIS -- TARGETING ASBESTOS-INDUCED CHRONIC INFLAMMATION -- REFERENCES -- CHAPTER 17 NANOMATERIALS -- POTENTIAL HEALTH EFFECTS OF NMs -- OXIDATIVE STRESS AND NMs -- INFLAMMATION AND NMs -- GENOTOXICITY OF NMs -- CARCINOGENICITY OF NMs -- EPIGENETIC EFFECTS OF NMs -- CONCLUDING REMARKS -- Acknowledgments -- REFERENCES -- CHAPTER 18 INFLAMMATORY PATHWAYS OF RADIATION-INDUCED TISSUE INJURY -- INTERACTION OF IR WITH CELLS AND TISSUES -- BIOLOGICAL EFFECTS OF IR -- TYPES OF RADIATION EFFECTS
DNA DAMAGE: CHROMOSOMAL INSTABILITY -- CLUSTERED DNA DAMAGES -- SIGNIFICANT CONTRIBUTION OF INFLAMMATION IN THE CHRONIC LATE EFFECTS OF RADIATION -- INFLAMMATION AND RADIATION-INDUCED NONTARGETED EFFECTS -- RADIATION-INDUCED UP-REGULATION OF INFLAMMATORY MEDIATORS -- CENTRAL NERVOUS SYSTEM -- CIRCULATORY SYSTEM -- LUNG -- CONCLUDING REMARKS -- Acknowledgments -- REFERENCES -- CHAPTER 19 PHOTOCARCINOGENESIS AND INFLAMMATION -- DNA DAMAGE CAUSED BY SUNLIGHT -- UV-INDUCED DNA LESIONS AND MUTATIONS IN SKIN CANCERS -- UV-INDUCED INFLAMMATION AND SKIN CANCERS -- DNA DAMAGE AND INFLAMMATION -- DIFFERENCE BETWEEN CHEMICALLY INDUCED CANCER AND PHOTOCARCINOGENESIS -- MELANOMA AND UV-INDUCED INFLAMMATION -- THE ROLE OF UVA IN PHOTOCARCINOGENESIS -- DEVELOPMENT OF SKIN CANCER IN GENETIC DISORDERS -- UV-INDUCED IMMUNE SUPPRESSION -- REFERENCES -- CHAPTER 20 CHEMOPREVENTION OF COLORECTAL CANCER BY ANTI-INFLAMMATORY AGENTS -- ANTI-INFLAMMATORY AGENTS TARGETING CYCLOOXYGENASE -- ANTI-INFLAMMATORY AGENTS TARGETING iNOS -- ANTI-INFLAMMATORY AGENTS TARGETING PPAR- -- OTHER CANDIDATES AS CANCER CHEMOPREVENTIVE AGENTS WITH ANTI-INFLAMMATORY POTENTIAL -- FUTURE PROSPECTS -- Combination Effects -- Targeting Obesity -- Clinical Trials -- REFERENCES -- CHAPTER 21 NUTRACEUTICALS AND COLON CANCER PREVENTION -- PATHOGENESIS OF COLON CANCER -- Hereditary Colon Cancer -- Nonhereditary Colon Cancer (Sporadic) -- Colitis-Associated Colorectal Cancer -- CHEMOPREVENTIVE MECHANISMS BY NUTRACEUTICALS -- Molecular Targets of Nutraceutical Chemoprevention -- MicroRNA -- Cancer Stem Cells -- EXPERIMENTAL MODELS OF COLON CARCINOGENESIS IN CHEMOPREVENTION -- In Vitro Models -- Genetically Modified Animals -- Xenoplant Models -- Chemically Induced Models -- NUTRACEUTICAL AND COLON CANCER -- CONCLUDING REMARKS -- REFERENCES
CHAPTER 22 CANCER CHEMOPREVENTION TARGETING COX-2 USING DIETARY PHYTOCHEMICALS
A new perspective on the link between inflammation and cancer Inflammation is the human body's normal biological response to threats in the modern world, as well as a defense against the harmful influence of pathogens, the environment, and poor nutrition. But what happens when the inflammatory response is triggered repeatedly and sustained for long periods of time? Cancer and Inflammation Mechanisms: Chemical, Biological, and Clinical Aspects discusses the mechanisms by which chronic inflammation can lead to cancer, the various causative agents, and possible prevention methods. A compilation of the latest information coming out of the various fields of cancer research, this book provides a detailed look at inflammation-related carcinogenesis from the perspective of researchers at the forefront of the field. It takes an interdisciplinary approach to the topic, and provides comprehensive information about the major factors at work in inflammation, cancer, and the intersection of the two conditions. Topics include: A general overview of inflammation-related cancer The biochemistry of inflammation and its effects on DNA Molecular biology and the role of microRNA in carcinogenesis Specific causative agents including oncogenic viruses, asbestos, and nanomaterial Anti-inflammatories, nutraceuticals, and other preventative measures A deeper understanding of the mechanisms behind inflammation-related carcinogenesis can lead to better patient outcomes by improving diagnostics and prevention, as well as altering the approach to treatment. Cancer and Inflammation Mechanisms: Chemical, Biological, and Clinical Aspects provides the knowledge base researchers need to push the field forward
Description based on publisher supplied metadata and other sources
Electronic reproduction. Ann Arbor, Michigan : ProQuest Ebook Central, 2020. Available via World Wide Web. Access may be limited to ProQuest Ebook Central affiliated libraries
鏈接 Print version: Hiraku, Yusuke Cancer and Inflammation Mechanisms : Chemical, Biological, and Clinical Aspects Somerset : John Wiley & Sons, Incorporated,c2014 9781118160305
主題 Carcinogenesis.;Inflammation -- Mediators.;Inflammation -- Immunological aspects.;Cancer -- Immunological aspects
Electronic books
Alt Author Kawanishi, Shosuke
Ohshima, Hiroshi
Hiraku, Yusuke
Kawanishi, Shosuke
Ohshima, Hiroshi
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