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作者 Spencer, Peter
書名 Anticancer Drugs : Design, Delivery and Pharmacology
出版項 New York : Nova Science Publishers, Incorporated, 2009
©2009
國際標準書號 9781608766291 (electronic bk.)
9781607410041
book jacket
說明 1 online resource (287 pages)
text txt rdacontent
computer c rdamedia
online resource cr rdacarrier
系列 Cancer Etiology, Diagnosis and Treatments
Cancer Etiology, Diagnosis and Treatments
附註 Intro -- Anticancer Drugs: Design, Delivery and Pharmacology -- Contents -- Preface -- Research and Review Studies -- Micro- and Nano-Particulate Drug Delivery Systems for Cancer Treatment -- Abstract -- I. Introduction -- II. Polymeric Particles -- III. Vesicular Systems -- IV. Solid Lipid Nanoparticles -- V. Squalenoyl Nanomedicines -- VI. Passive Targeting to Tumors -- VII. Active Targeting to Tumors -- VIII. Oral Chemotherapy -- IX. Drug Delivery to Brain Tumors -- X. Approaches for Overcoming Multi-Drug Resistance (MDR) -- XI. Conclusion -- XII. References -- Geldanamycin Derivatives as Promising Anticancer Drugs: Therapy via Hsp90 Inhibition -- Abstract -- Introduction -- Hsp90: Essential Chaperone and Unique Target for Anticancer Therapy -- Geldanamycin and its Less Toxic Analogues as Anticancer Single Agents -- 17AAG and 17DMAG Can Sensitize Cancer Cells to other Chemotherapeutic Drugs -- 17AAG and 17DMAG as Selective Radiosensitizers of Tumor -- 17AAG and 17MDAG Against Tumor Vasculature -- Problems and Perspectives -- Conclusion -- References -- Synergistic Antitumor Activity of Metronomic Dosing Chemotherapy in Combination with Liposomal Anticancer Drug -- Abstract -- Abbreviations -- 1. Introduction -- 2. Low Dose Metronomic Chemotherapy -- 3. Mechanism of Anti-angiogenesis with Low Dose Cyclophosphamide (CDA) Dosing -- 4. Delivery of Anticancer Drug and Transport to Solid Tumors -- 5. Passive Targeting of Long-circulating Liposome into Solid Tumors due to Enhanced Permeability and Retention (EPR) Effect -- 6. Clinical Application of PEGlyated Liposome -- 7. Tumor Vascular Manipulation -- 8. Synergistic Antitumor Activity of Metronomic Dosing of CPA in Combination with DXR-containing PEGlyated Liposome -- 9. Conclusion -- Acknowledgments -- References -- Organotin Polyethers as Anticancer Drugs -- Abstract -- Introduction
Cell Line Studies -- Molecular Level Studies -- Advantageous of Polymeric Drugs -- Organotin Polyethers-Synthesis -- Organotin Polyethers-Cell Line Results -- Diethylstilbestrol Polymers -- Alkane-Derived Polymers -- Butyne-Derived Polyethers -- Hydroquinone and Hydroquinone Derivatives -- Summary -- Future -- References -- Studies on Anti-Cancer Agents: Phenolic Compounds and Their Pharmacological Activity -- Abstract -- Quercetin -- Silymarin -- Rutin -- Rosmarinic Acid -- Tea Flavonoids -- Hydroxytyrosol -- Ellagic Acid -- Apigenin -- Cosmociin and Narciclasine -- References -- Design of Novel Anticancer Drugs Utilizing Busulfan for Optimizing Pharmacological Properties and Pattern Recognition Techniques for Elucidation of Clinical Efficacy -- Abstract -- Introduction -- Determination of Pattern Outcome and Molecular Modeling -- Resolution of Findings and Discussion -- Conclusion -- Acknowledgements -- References -- Analysis of Associations among Novel Property Descriptors and Their Capacity in Determining Clinical Efficacy by Utilizing Pattern Recognition Techniques -- Abstract -- Introduction -- Molecular Modeling and Algorithmic Determination of Properties -- Significance and Determination of Descriptors for Analysis -- Description and Renumeration of Underlying Associations -- Conclusion -- Acknowledgments -- References -- Insights into the Mode of Action of Bioreductive Ruthenium Cytotoxins -- Abstract -- Introduction -- Investigational Azole-Based Ruthenium (III) Drugs - KP1019 and NAMI-A -- Transferrin-Mediated Endocytosis -- Electrochemical Properties of Ru(III) Complexes -- Increased Cytotoxicity with Increasing Redox Potential -- Conclusion -- References -- Marine Crystal Minerals (MCM) Induce Apoptosis of Human Metastatic Breast Cancer MDA-MB-231 Cells in vitro -- Abstract -- Introduction -- Materials and Methods -- Results
Discussion -- References -- Index
Description based on publisher supplied metadata and other sources
Electronic reproduction. Ann Arbor, Michigan : ProQuest Ebook Central, 2020. Available via World Wide Web. Access may be limited to ProQuest Ebook Central affiliated libraries
鏈接 Print version: Spencer, Peter Anticancer Drugs : Design, Delivery and Pharmacology New York : Nova Science Publishers, Incorporated,c2009 9781607410041
主題 Antineoplastic agents.;Cancer -- Chemotherapy
Electronic books
Alt Author Holt, Walter
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