Record:   Prev Next
作者 Tamanoi, Fuyuhiko
書名 The Enzymes
出版項 San Diego : Elsevier Science & Technology, 2015
©2015
國際標準書號 9780128038772 (electronic bk.)
9780128038765
book jacket
說明 1 online resource (285 pages)
text txt rdacontent
computer c rdamedia
online resource cr rdacarrier
系列 Issn Ser. ; v.Volume 37
Issn Ser
附註 Front Cover -- Mechanism of the Anticancer Effect of Phytochemicals -- Copyright -- Contents -- Contributors -- Preface -- Chapter One: How Phytochemicals Prevent Chemical Carcinogens and/or Suppress Tumor Growth? -- 1. Introduction -- 2. Phytochemicals Application in Chemoprevention Strategies -- 2.1. Blocking Initiation/Reversing Promotion -- 2.2. Activating Phase II Detoxifying Enzymes -- 2.3. Prooxidant/Antioxidant Activities -- 2.4. Protection Against Radiation -- 2.5. Alteration in Signaling Pathways -- 2.6. Effect on Cell-Cell Adhesion Machinery -- 2.7. Induction of Epigenetic Changes -- 3. Phytochemicals Usage as Chemotherapeutic -- 3.1. Inhibition of Enzymes -- 3.1.1. Inhibition of Topoisomerases I or II -- 3.1.2. Effect on Telomerase -- 3.1.3. Other Enzymes -- 3.2. Direct Binding to Biomacromolecules -- 3.3. Epigenetic Alteration/Chromatin Modification -- 3.3.1. Histone Modifications: Acetylation/Deacetylation and Methylation/Demethylation -- 3.3.2. DNA Methylation Status -- 3.4. RNA Modulation -- 3.5. Autophagy and UPR68 -- 3.6. Apoptosis Induction -- 3.7. Cell Cycle Arrest -- 3.8. Inhibiting Angiogenesis -- 3.9. Adjuvant/Combinatorial Therapy -- 4. Summary -- References -- Chapter Two: Quercetin and Tryptanthrin: Two Broad Spectrum Anticancer Agents for Future Chemotherapeutic Interventions -- 1. Introduction -- 2. Quercetin -- 2.1. Source -- 2.2. Biosynthesis -- 2.3. Structure and Antioxidative Property -- 2.4. Properties -- 2.4.1. Antioxidant Property -- 2.4.2. Free Radical Scavenging Activity -- 2.4.3. Nitric Oxide Inhibitory Action -- 2.4.4. Inhibition of Xanthine Oxidase -- 2.4.5. Interaction with Other Enzyme Systems -- 2.5. Pharmacokinetics -- 2.6. Role as an Anticancer Agent -- 2.6.1. Cell Cycle Regulation -- 2.6.2. Quercetińs Effect on Apoptosis -- 2.6.3. Inhibition of Pathways Involved in Tumor Growth and Invasiveness
2.7. Quercetińs Role as an Anti-Inflammatory Agent -- 2.8. Quercetińs Influence on p53 -- 2.9. Quercetińs Nontoxicity Against Normal Cells -- 2.10. Quercetińs Action Against Chemical-Induced Tumor and Xenograft -- 2.11. Synergism with Other Drugs -- 2.12. Clinical Study -- 3. Tryptanthrin -- 3.1. Chemistry -- 3.2. Source -- 3.3. Medicinal Value -- 3.4. Cytotoxic and Anticancer Properties of Tryptanthrin -- 3.5. Structural Modification of Tryptanthrin for Increasing its Bioactivity -- 3.6. Tryptanthrin Prevents Development of Cancer by the Inhibition of Various Molecular Events -- 3.6.1. Antioxidant Activity -- 3.6.2. Anti-Inflammatory Activity -- 3.7. Angiogenesis -- 3.8. Toxicological Analysis -- 4. Conclusion -- Acknowledgement -- References -- Chapter Three: Potential Anticancer Properties and Mechanisms of Action of Withanolides -- 1. Introduction -- 2. Reactive Oxygen Species Signaling -- 3. Cytoskeletal Organizing and Structural Proteins -- 4. Proteasomal Inhibition -- 5. Inhibition of Mitosis -- 6. Transcription Factors -- 7. Heat Shock Proteins -- 8. Metabolic Enzymes -- 9. Synergistic Action -- References -- Chapter Four: Prenylated Dihydrochalcones from Artocarpus altilis as Antiausterity Agents -- 1. Introduction -- 2. Chemical Constituents of A. altilis -- 3. Biosynthesis of Prenylated Phenolic Compound -- 4. Cytotoxicity of Prenylated Flavonoids and Dihydrochalcones in A. altilis -- 4.1. Cytotoxicity of Prenylated Flavonoids -- 4.2. Cytotoxicity of Prenylated Dihydrochalcones -- 4.3. Antiausterity Activity of Prenylated Dihydrochalcones -- 4.4. Toxicology of A. altilis -- 5. Conclusions and Future Perspectives -- References -- Chapter Five: Mechanisms of the Anticancer Effects of Isothiocyanates -- 1. Introduction -- 2. Uptake of ITCs by Cancer Cells -- 3. Targets of ITCs in Cancer Cells -- 3.1. Benzyl Isothiocyanate (BITC)
3.1.1. Cancer Cell Progression -- 3.1.2. Mitochondrial Apoptosis -- 3.1.3. Metastasis -- 3.1.4. Angiogenesis -- 3.1.5. In Vivo Studies -- 3.1.6. Toxicity -- 3.2. Phenethyl Isothiocyanate (PEITC) -- 3.2.1. Cancer Cell Progression -- 3.2.2. Mitochondrial Apoptosis -- 3.2.3. Metastasis -- 3.2.4. In Vivo -- 3.2.5. Clinical Trial -- 3.3. Sulforaphane -- 3.3.1. Cell Proliferation and Growth -- 3.3.2. Angiogenesis -- 3.3.3. Mitochondrial Cell Death -- 3.3.4. Metastasis -- 3.3.5. In Vivo Studies -- 3.3.6. Toxicity Studies -- 3.4. Allyl Isothiocyanate -- 3.4.1. Cancer Cell Progression -- 3.4.2. Mitochondrial Apoptosis -- 3.4.3. Metastasis -- 3.4.4. In Vivo Studies -- 3.4.5. Toxicity Studies -- 4. Biochemical Mechanisms of the Chemopreventive Effects of ITCs -- 5. Combination Therapy -- 6. Conclusion -- Acknowledgments -- References -- Chapter Six: Mechanism of the Anticancer Effect of Lycopene (Tetraterpenoids) -- 1. Introduction -- 2. Bioavailability and Tissue Distribution of Lycopene -- 3. Antioxidant Activity -- 4. Anti-inflammatory Activity -- 5. Potential Mechanisms of Tumor-Inhibitory Activity of Lycopene -- 5.1. Modulation of Growth Factor and Growth Factor Receptor Signaling -- 5.2. Blockade of Cell Cycle Progression -- 5.3. Apoptosis-Inducing Activity -- 6. Inhibitory Effects on Invasion and Metastasis -- 7. Potential Role of Lycopene for the Prevention and Therapy of Cancer -- 7.1. Lycopene and Prostate Cancer -- 7.2. Lycopene and Breast Cancer -- 7.3. Lycopene and Lung Cancer -- 8. Conclusion and Future Perspectives -- References -- Chapter Seven: Anticancer Mechanism of Sulfur-Containing Compounds -- 1. Introduction -- 2. Allium Compounds -- 2.1. Induction of Apoptosis in Malignant Cells -- 2.1.1. Modulation of Bcl-2 and Mitogen-Activated Protein Kinase Family -- 2.1.2. Activation of p53 -- 2.1.3. ROS Generation
2.1.4. Microtubule Alterations and Calcium Homeostasis Changes -- 2.2. Induction of Apoptosis in Animal Models -- 3. Brassica Compounds -- 3.1. Induction of Apoptosis in Malignant Cells -- 3.1.1. Involvement of the Intrinsic and/or Extrinsic Apoptotic Pathway -- 3.1.2. Modulation of Bcl-2 and MAPK Family -- 3.1.3. Caspase Activation -- 3.1.4. ROS Generation -- 3.1.5. Modulation of Histone Deacetylase -- 3.1.6. Microtubule Alteration -- 3.2. Induction of Apoptosis in Animal Models -- 4. Conclusion -- References -- Chapter Eight: The Role of Soy Phytoestrogens on Genetic and Epigenetic Mechanisms of Prostate Cancer -- 1. Introduction -- 2. Classification and Metabolism of Soy Phytoestrogens -- 3. Molecular Effects of Soy Phytoestrogens -- 3.1. Estrogenic Activity of Soy Phytoestrogens -- 3.2. Effects of Soy Phytoestrogens in Mechanisms of Cell-Cycle Processes -- 3.3. Effects of Soy Phytoestrogens on Apoptosis -- 3.4. Effects of Soy Phytoestrogens on Inhibition of Angiogenesis -- 3.5. Effects of Soy Phytoestrogens on Inhibition of Metastasis -- 3.6. Antioxidant Activity of Soy Phytoestrogens -- 4. Effects of Soy Phytoestrogens on Epigenetic Mechanisms of Prostate Cancer -- 4.1. DNA Methylation -- 4.2. Histone Modifications -- 4.3. Regulation of miRNAs -- 5. Clinical Trials -- 6. Conclusion -- References -- Author Index -- Subject Index -- Color Plate
Volume 37 will provide details on the major chemical constituents of medicinal plants and their mechanism of action as the anticancer compounds. This special issue, in addition to the previous volume (volume 36 of the Enzyme series was on the topic of Natural Products and Cancer Signaling Targets: Isoprenoids, Polyphenols and Flavonoids), will highlight the significant advance made in the field in elucidating mechanisms of anticancer effect of the major phytochemicals. Contributions from leading authorities Informs and updates on all the latest developments in the field
Description based on publisher supplied metadata and other sources
Electronic reproduction. Ann Arbor, Michigan : ProQuest Ebook Central, 2020. Available via World Wide Web. Access may be limited to ProQuest Ebook Central affiliated libraries
鏈接 Print version: Tamanoi, Fuyuhiko The Enzymes San Diego : Elsevier Science & Technology,c2015 9780128038765
主題 Chemical kinetics.;Enzymes.;Kinetics
Electronic books
Alt Author Bathaie, S. Zahra
Record:   Prev Next