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050  4 GN480.25 -- .C38 2004eb 
082 0  304.6/0945 
100 1  Cavalli-Sforza, Luigi Luca 
245 10 Consanguinity, Inbreeding, and Genetic Drift in Italy (MPB
       -39) 
264  1 Princeton :|bPrinceton University Press,|c2004 
264  4 |c©2004 
300    1 online resource (329 pages) 
336    text|btxt|2rdacontent 
337    computer|bc|2rdamedia 
338    online resource|bcr|2rdacarrier 
490 1  Monographs in Population Biology Ser. ;|vv.39 
505 0  Cover -- Title -- Copyright -- Contents -- Acknowledgments
       -- 1. History of This Investigation and Structure of This 
       Book -- 1.1 Introduction -- 1.2 History of This Research -
       - 1.3 Consanguinity -- 1.4 Inbreeding Measurement -- 1.5 
       Inbreeding Effects -- 1.6 Random Genetic Drift -- 1.7 
       Research on Drift in the Parma Valley -- 1.8 Genetic Uses 
       of Surnames -- 1.9 A Summary of Published Studies on 
       Consanguinity and Inbreeding, with Special Reference to 
       Italy -- 1.10 Structure of This Book -- 2. Customs and 
       Legislation Affecting Consanguineous Marriages, with 
       Special Attention to the Catholic Church -- 2.1 Early and 
       Medieval Christian Tradition -- 2.2 Traditional Methods of
       Consanguinity Evaluation: The Roman and the German Methods
       -- 2.3 Justifications of the Dispensation Request -- 3. 
       Demographic Factors Affecting the Frequencies of 
       Consanguineous Marriage-A Study in Northern Emilia -- 3.1 
       Nature and Interest of the Problem -- 3.2 Relations to 
       Population Structure -- 3.3 Number of Sibs, Distribution 
       of Family Sizes, and Observed Abundance of Relatives -- 
       3.4 Consanguinity Degrees and Observed Numbers of 
       Consanguinity Dispensations in Northern Emilia -- 3.5 
       Pedigree Types, Pedigree Codes, and Proofs of the 
       Influence of Age at Marriage and of the Sex of 
       Intermediate Ancestors -- 4. Probability of Consanguineous
       Marriages -- 4.1 Theory of Age Effects on the Frequency of
       Consanguineous Marriages -- 4.2 Migration as a Factor 
       Affecting the Frequency of Consanguineous Marriages -- 4.3
       The Role of Women in Maintaining Family Ties among 
       Relatives -- 4.4 Observed and Expected Frequencies of 
       Major Consanguinity Degrees -- 5. Consanguinity, 
       Inbreeding, and Observed Genetic Drift in the Parma Valley
       -- 5.1 The Parma Valley and the Origin of This 
       Investigation -- 5.2 Geography of the Parma Valley -- 5.3 
       Consanguinity and Inbreeding in the Parma Valley 
505 8  5.4 Blood Groups and Genetic Drift -- 5.5 Surnames and 
       Genetic Drift -- 5.6 Correlations of Inbreeding and Drift 
       -- 6. A Computer Simulation of the Upper Parma Valley 
       Population -- 6.1 The Need for a Population Simulation -- 
       6.2 Structure of the Simulation -- 6.3 The Migration 
       Matrix -- 6.4 Is Drift the Only Cause of Genetic Variation
       in the Parma Valley? -- 6.5 Expected and Observed 
       Consanguinity -- 7. Islands -- 7.1 Italian Islands -- 7.2 
       Sardinia -- 7.3 Sicily -- 7.4 Aeolian Islands -- 8. 
       Effects of Inbreeding on Normal and Pathological 
       Phenotypes -- 8.1 Introduction -- 8.2 Normal Quantitative 
       Phenotypes: Stature and Chest Girth -- 8.3 Mortality, 
       Fertility, and Sterility -- 8.4 Incidence of Disease 
       Groups from Surveys of Hospital Populations -- 8.5 Study 
       of Specific Recessive Diseases -- 9. Consanguineous 
       Marriages in Italy: Data from the Vatican Archives -- 9.1 
       Introduction -- 9.2 Variations of Consanguinity over Time 
       -- 9.3 Geographical Variations: Provinces and Regions -- 
       9.4 Space-Time Analysis: Four Models of Declining 
       Consanguinity in Italian Regions -- 9.5 Factors 
       Responsible for Space and Time Differences in 
       Consanguinity: Choice of Variables and Their Meaning -- 
       9.6 Demographic Variables: Birthrate, Death Rate, and 
       Demographic Transition -- 9.7 Effect on Consanguinity of 
       Environmental Variables of Socioeconomic and Ecological 
       Meaning -- 9.8 An Attempt at a General Synthesis -- 10. 
       Geography of Demes in Italy -- 10.1 Population Sampling --
       10.2 Random Mating, Mendelian Populations, and Demes -- 
       10.3 Comparing Genetic and Demographic Approaches to the 
       Study of Demes -- 10.4 Are comuni (Communes) Demes? -- 
       10.5 The Negative Correlation Between N and m -- 10.6 
       Using Surnames for Evaluating Drift -- 10.7 A Drift Map of
       Italy by Communes -- 10.8 Statistical Observations on the 
       Italian Drift Map -- 11. Conclusions -- 11.1 Human 
       Consanguinity 
505 8  11.2 Inbreeding -- 11.3 Genetic Drift -- 11.4 Demes, 
       Isolates, and Migration -- Bibliography -- Index 
520    In 1951, the geneticist Luigi Luca Cavalli-Sforza was 
       teaching in Parma when a student--a priest named Antonio 
       Moroni--told him about rich church records of demography 
       and marriages between relatives. After convincing the 
       Church to open its records, Cavalli-Sforza, Moroni, and 
       Gianna Zei embarked on a landmark study that would last 
       fifty years and cover all of Italy. This book assembles 
       and analyzes the team's research for the first time. Using
       blood testing as well as church records, the team 
       investigated the frequency of consanguineous marriages and
       its use for estimating inbreeding and studying the 
       relations between inbreeding and drift. They tested the 
       importance of random genetic drift by studying population 
       structure through demography of the last three centuries, 
       using it to predict the spatial variation of frequencies 
       of genetic markers. The authors find that drift-related 
       genetic variation, including its stabilization by 
       migration, is best predicted by computer simulation. They 
       also analyze the usefulness and limits of the concept of 
       deme for defining Mendelian populations. The genetic 
       effect of consanguineous marriage on recessive genetic 
       diseases and for the detection of dominance in metric 
       characters are also studied. Ultimately bringing together 
       the many strands of their massive project, Cavalli-Sforza,
       Moroni, and Zei are able to map genetic drift in all of 
       Italy's approximately 8,000 communes and to demonstrate 
       the relationship between each locality's drift and various
       ecological and demographic factors. In terms of both 
       methods and findings, their accomplishment is tremendously
       important for understanding human social structure and the
       genetic effects of drift and inbreeding 
588    Description based on publisher supplied metadata and other
       sources 
590    Electronic reproduction. Ann Arbor, Michigan : ProQuest 
       Ebook Central, 2020. Available via World Wide Web. Access 
       may be limited to ProQuest Ebook Central affiliated 
       libraries 
650  0 Consanguinity -- Italy.;Inbreeding -- Italy.;Human 
       population genetics -- Italy.;Human genetics -- Variation 
655  4 Electronic books 
700 1  Moroni, Antonio 
700 1  Zei, Gianna 
776 08 |iPrint version:|aCavalli-Sforza, Luigi Luca
       |tConsanguinity, Inbreeding, and Genetic Drift in Italy 
       (MPB-39)|dPrinceton : Princeton University Press,c2004
       |z9780691089928 
830  0 Monographs in Population Biology Ser 
856 40 |uhttps://ebookcentral.proquest.com/lib/sinciatw/
       detail.action?docID=1113402|zClick to View