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書名 Osteoporosis [electronic resource] / edited by Robert Marcus ... [et al.]
出版項 Amsterdam ; Boston : Elsevier Academic Press, c2008
國際標準書號 9780123705440
book jacket
版本 3rd ed
說明 2 v. (xxv, 1941 p., [16] p. of plates) : ill. ; 29 cm
附註 Includes bibliographical references and index
Introduction -- The Bone Organ System: Form and Function -- The Nature of Osteoporosis -- The Economics of Osteoporosis -- Reflections on Osteoporosis -- Skeletal Heterogeneity and the Purposes of Bone Remodeling: Implications for the -- Understanding of Osteoporosis -- Basic Science/Bone Biology -- Osteoblast Biology -- Osteoclast Biology -- Osteocytes -- The Regulatory Role of Matrix Proteins in Mineralization of Bone -- Development of the Skeleton -- Mouse Genetics as a Tool to Study Bone Development and Physiology -- Parathyroid Hormone and Parathyroid Hormone-Related Protein -- Vitamin D: Biology, Action, and Clinical Implications -- Regulation of Bone Cell Function by Estrogens -- Androgens and Skeletal Biology: Basic Mechanisms -- Phosphatonins -- Wnt Signaling in Bone -- Cytokines and Bone Remodeling -- Skeletal Growth Factors -- Intercellular Communication During Bone Remodeling -- Structural and Biomechanics -- Skeletal Development: Mechanical Consequences of Growth, Aging and Disease -- Inhibition of Osteoporosis by Biophysical Intervention -- Biomechanics of Age-Related Fractures -- Bone Quality -- Epidemiology & Risk Factors -- Epidemiologic Methods in Studies of Osteoporosis -- Race, Ethnicity and Osteoporosis -- The Study of Osteoporotic Fractures (SOF): Major Findings and Contributions -- Bone Mineral Acquisition in Utero and During Infancy and Childhood -- Bone Acquisition in Adolescence -- Genetic Determinants of Osteoporosis -- Nutrition and Risk for Osteoporosis -- Physical Activity in Prevention of Osteoporosis and Associated Fractures -- Premenopausal Reproductive and Hormonal Characteristics and the Risk for Osteoporosis -- Non-Skeletal Risk Factors for Osteoporosis and Fractures -- Falls as Risk Factors for Fracture -- Assessment of Fracture Risk -- Outcomes of Osteoporotic Fractures -- Pathophysiology -- Local and Systemic Factors in the Pathogenesis of Osteoporosis -- Animal Models for Osteoporosis -- Estrogen, Bone Homeostasis and Osteoporosis -- Postmenopausal Osteoporosis: How the Hormonal Changes of Menopause Cause Bone Loss -- Osteoporosis in Men: Epidemiology, Pathophysiology, and Clinical Characterization -- Osteoporosis in Childhood and Adolescence -- Glucocorticoid-Induced Osteoporosis -- Adult Scoliosis, Degenerative Disease, and BMD: a Sub-Segmental Analytic Approach -- Mechanisms of Immobilization-induced Bone Loss -- Leptin-Dependent Regulation of Bone Mass -- Thyroid Hormone and the Skeleton -- Osteoporosis in Gastrointestinal, Pancreatic, and Hepatic Disease -- The Skeletal Actions of Parathyroid Hormone in Primary Hyperparathyroidism and in Osteoporosis -- Osteogenesis Imperfecta and Other Defects of Bone Development as Occasional Causes of Adult Osteoporosis -- Osteoporosis Associated with Illnesses and Medications -- Transplantation Osteoporosis -- Osteoporosis Associated with Cancer Therapy -- Osteoporosis Associated with Pregnancy -- Osteoporosis Associated with Rheumatologic Disease -- Oral Bone Loss and Systemic Osteopenia: Potential Treatment and Risks -- Localized Osteoporosis -- Evaluation and Management -- Evaluation of the Patient with Osteoporosis or at Risk for Osteoporosis -- Who Should be Screened: Who Should be Treated? -- Radiology of Osteoporosis -- Clinical Use of Bone Densitometry -- Biochemical Markers of Bone Turnover in Osteoporosis -- The Conundrum of Compliance and Persistence with Oral Bisphosphonates for Postmenopausal Osteoporosis -- An Orthopedic Perspective of Osteoporosis -- Lessons from Bone Histomorphometry on the Mechanism of Action of Osteoporosis Drugs -- Pharmacology and Therapeutics -- Design Considerations for Clinical Investigations of Osteoporosis -- Regulatory Considerations for the Design and Conduct of Osteoporosis Registration Trials -- Evidence-Based Osteoporosis Care -- The Role of Calcium in the Treatment of Osteoporosis -- Vitamin D and its Metabolites and Analogs in the Management of Osteoporosis -- Estrogen Therapy: Prevention and Treatment of Osteoporosis -- Estrogen Analogues: Selective Estrogen Receptor Modulators (SERMs) and Phytoestrogens -- Bisphosphonates: Pharmacology and Use in the Treatment of Osteoporosis -- Calcitonin in Osteoporosis -- Strontium Therapy for Osteoporosis -- Androgens -- Treatment with PTH Peptides -- Growth Hormone and Insulin-like Growth Factors: Potential Applications and Limitations in the Management of Osteoporosis -- New approaches to Osteoporosis Therapeutics
The bone organ system: form and function -- The nature of osteporosis -- The economics of osteoporosis -- Reflections on osteoporosis -- Skeletal heterogeneity and the purposes of bone remodeling: implications for the understanding of osteporosis -- Osteoblast biology -- Osteoclast biology -- Osteocytes -- The regulatory role of matrix proteins in mineralization of bone -- Development of the skeleton -- Mouse genetics as a tool to study bone development and physiology -- Parathyroid hormone and parathyroid hormone-related protein -- Vitamin D: biology, action, and clinical implications -- Regulation of bone cell function by estrogens -- Androgens and skeletal biology: basic mechanisms -- Phosphatonins -- Wnt Signaling in bone -- Cytokins and bone remodeling -- Skeletal growth factors -- Intercellular communication during bone remodeling -- Skeletal development: mechanical consequences of growth, aging, and disease -- Inhibition of osteoporosis by biophysical intervention -- Biomechanics of age-related fractures -- Bone quality -- Epidemiologic methods in studies of osteoporosis -- Race, ethnicity and osteoporosis -- The study of osteoporotic fractures: major findings and contributions -- Bone mineral acquistion In Utero and during infancy and childhood -- Bone acquisition in adolescence -- Genetic determinants of osteoporosis -- Nutrition and risk for osteoporosis -- Physical activity in prevention of osteoporosis and associated fractures -- Premenopausal reproductive and hormonal characteristics and the risk for osteoporosis -- Nonskeletal risk factors for osteoporosis and fractures -- Falls as risk factors for fracture -- Assessment of fracture risk -- Outcomes of osteoporotic fractures -- Local and systemic factors in the pathogenesis of osteoporosis -- Animal modesl for osteoporosis -- Estrogen, bone homeostasis, and osteoporosis -- Postmenopausal osteoporosis: how the hormonal changes of menopause cause bone loss -- Osteoporosis in men: epidemiology, pathophysiology, and clinical characterization -- Osteoporosis in childhood and adolescence --
Glucocorticoid-induced osteoporosis -- Adult scoliosis, degenerative disease, and BMD: a subsegmental analytic approach -- Mechanisms of immobilization-induced bone loss -- Leptin-dependent regulation of bone mass -- Thyroid hormone and the skeleton -- Osteoporosis in gastrointestinal, pancreatic, and hepatic diseases -- The skeletal actions of parathyroid hormone in primary hyperparathyroidism and in osteoporosis -- Osteogenesis imperfecta and other defects of bone development as occasional causes of adult osteoporosis -- Osteoporosis associated with illnesses and medications -- Transplantation osteoporosis -- Osteoporosis associated with cancer therapy -- Osteoporosis associated with pregnancy -- Osteoporosis associated with rheumatologic disorders -- Oral bone loss and systemic osteopenia: potential treatment and risks -- Localized osteoporosis -- Evaluation of the patient with osteoporosis or at risk for osteoporosis -- Who should be screened: who should be treated? -- Radiology of osteoporosis -- Clinical use of bone densitometry -- Biochemical markers of bone turnover in osteoporosis -- The conundrum of compliance and persistence with oral biophosphonates for postmenopausal osteoporosis -- An orthopedic perspective of osteoporosis -- Lessons from the bone histomorphometry on the mechanism of action of osteoporosis drugs -- Design considerations for clinical investigations of osteoporosis -- Regulatory considerations for the design and conduct of osteoporosis registration trials -- Evidence-based osteoporosis care -- The role of calcium in the treatment of osteoporosis -- Vitamin D and its metabolites and analogs in the management of osteoporosis -- Estrogen therapy: prevention and treatment of osteoporosis -- Estrogen analogues: selective estrogen receptor modulators and phytoestrogens -- Bisphosphonates: pharmacology and use in the treatment of osteoporosis -- Calcitonin in osteoporosis -- Strontium ranelate -- Androgens -- Treatment with PTH peptides -- Growth hormone and insulin-like growth factors: potential applications and limitations in the management of osteoporosis -- New approaches to osteoporosis therapeutics
Electronic reproduction. Amsterdam : Elsevier Science & Technology, 2008. Mode of access: World Wide Web. System requirements: Web browser. Title from title screen (viewed on May 14, 2008). Access may be restricted to users at subscribing institutions
Now in its third edition, Osteoporosis, is the most comprehensive, authoritative reference on this disease. Written by renowned experts in the field, this two-volume reference is a must-have for academic and medical libraries, physicians, researchers, and any company involved in osteoporosis research and development. Worldwide, 200 million women between 60-80 suffer from osteoporosis and have a lifetime risk of fracture between 30 and 40 percent continuing to make osteoporosis a hot topic in medicine. This newest edition covers everything from basic anatomy and physiology to diagnosis, management and treatment in a field where direct care costs for osteoporitic fractures in the U.S. reach up to $18 billion each year. NEW TO THIS EDITION: *Recognizes the critical importance of the Wnt signaling pathway for bone health *Incorporates new chapters on osteocytes, phosphatonins, mouse genetics, and CNS and bone *Examines essential updates on estrogen prevention and treatment and the recent results from the WHI *Discusses the controversial topics of screening and clinical trial design for drug registration *Includes essential updates on therapeutic uses of calcium, vitamin D, SERMS, bisphosphonates, and parathyroid hormone * Offers critical reviews of reproductive and hormonal risk factors, ethnicity, nutrition, therapeutics, management, and economics comprising a tremendous wealth of knowledge in a single source not found elsewhere
鏈接 Original 9780123705440 0123705444 9780123705457 0123705452 9780123705464 0123705460 (OCoLC)181644546
主題 Osteoporosis -- pathology
Fractures, Bone -- pathology
Osteoporosis -- therapy
Electronic books. local
Alt Author Marcus, Robert, 1940-
ScienceDirect (Online service)
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