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作者 Kiang, Tony K.L., author
書名 Clinical pharmacokinetic and pharmacodynamic drug interactions associated with antimalarials / by Tony K.L. Kiang, Kyle John Wilby, Mary H.H. Ensom
出版項 Cham : Springer International Publishing : Imprint: Adis, 2015
國際標準書號 9783319105277 (electronic bk.)
9783319105260 (paper)
國際標準號碼 10.1007/978-3-319-10527-7 doi
book jacket
說明 1 online resource (vii, 146 pages) : illustrations, digital ; 24 cm
text txt rdacontent
computer c rdamedia
online resource cr rdacarrier
text file PDF rda
附註 Introduction -- Pharmacology of Recommended Antimalarial Agents -- Drug Interaction Potential of Antimalarial Drugs Based on Known Metabolic Properties of Antimalarials -- Pharmacokinetic Drug Interactions Affecting Antimalarials -- Effects of Antimalarials on the Pharmacokinetics of Co-Administered Drugs -- Effects of Antimalarials on the Pharmacokinetics of Co-Administered Antimalarials -- Pharmacodynamic Interactions: Clinical Evidence for Combination Therapy, In Vitro Interactions, and In Vivo Interactions -- Limitations, Future Directions, and Conclusions
This comprehensive review provides a systematic, unbiased analysis, critique and summary of the available literature and generates novel clinical decision-making algorithms which can aid clinicians and scientists in practice management and research development. Potential mechanisms for the identified drug interactions are deduced from available preclinical and in vitro data which are interpreted in the context of the in vivo findings. Current limitations and gaps in the literature are summarized, and potential future research directions / experimentations are also suggested. In addition to the main objective to review the available clinical pharmacokinetic and pharmacodynamic drug interactions associated with WHO-recommended antimalarial drugs on the market today (i.e. chloroquine, amodiaquine, sulfadoxine, pyrimethamine, mefloquine, artemisinin, artemether, artesunate, dihydroartemisinin, artemotil, lumefantrine, primaquine, atovaquone, proguanil, piperaquine and quinine), this book also provides succinct chapter summaries on the epidemiology of malaria infection, diagnosis and therapeutics, in vivo pharmacology and chemistry, preclinical pharmacology, in vitro pharmacodynamics, in vitro reaction phenotyping, and in vitro drug-drug interaction data associated with the identified antimalarial drugs
Springer
Host Item Springer eBooks
主題 Antimalarials -- Pharmacokinetics
Antimalarials -- Receptors -- Effect of drugs on
Medicine & Public Health
Tropical Medicine
Health Promotion and Disease Prevention
Drug Safety and Pharmacovigilance
Alt Author Wilby, Kyle John, author
Ensom, Mary H.H., author
SpringerLink (Online service)
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