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作者 Kerns, Edward Harvel
書名 Drug-like properties [electronic resource] : concepts, structure design and methods : from ADME to toxicity optimization / Edward H. Kerns and Li Di
出版項 Amsterdam ; Boston : Academic Press, c2008
國際標準書號 9780123695208
0123695201
book jacket
說明 xix, 526 p., [2] p. of plates : ill. (some col.) ; 27 cm
附註 Includes bibliographical references (p. 492) and index
Preface; Introductory Concepts; Physicochemical Properties; Disposition, Metabolism and Safety; Methods; Specific Topics; Answers to Problems; Appendix I: General References; Appendix II: Glossary
Electronic reproduction. Amsterdam : Elsevier Science & Technology, 2008. Mode of access: World Wide Web. System requirements: Web browser. Title from title screen (viewed on Dec. 9, 2008). Access may be restricted to users at subscribing institutions
Of the thousands of novel compounds that a drug discovery project team invents and that bind to the therapeutic target, typically only a fraction of these have sufficient ADME/Tox properties to become a drug product. Understanding ADME/Tox is critical for all drug researchers, owing to its increasing importance in advancing high quality candidates to clinical studies and the processes of drug discovery. If the properties are weak, the candidate will have a high risk of failure or be less desirable as a drug product. This book is a tool and resource for scientists engaged in, or preparing for, the selection and optimization process. The authors describe how properties affect in vivo pharmacological activity and impact in vitro assays. Individual drug-like properties are discussed from a practical point of view, such as solubility, permeability and metabolic stability, with regard to fundamental understanding, applications of property data in drug discovery and examples of structural modifications that have achieved improved property performance. The authors also review various methods for the screening (high throughput), diagnosis (medium throughput) and in-depth (low throughput) analysis of drug properties. * Serves as an essential working handbook aimed at scientists and students in medicinal chemistry * Provides practical, step-by-step guidance on property fundamentals, effects, structure-property relationships, and structure modification strategies * Discusses improvements in pharmacokinetics from a practical chemist's standpoint
Elsevier
鏈接 Original 9780123695208 0123695201 (DLC) 2007035586 (OCoLC)169452881
主題 Pharmaceutical chemistry
Drugs -- Structure-activity relationships
Drug development
Drugs -- Design
Drug Design
Drug Evaluation, Preclinical
Drug Toxicity
Pharmaceutical Preparations -- metabolism
Pharmacokinetics
Structure-Activity Relationship
Electronic books. local
Alt Author Di, Li
ScienceDirect (Online service)
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