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書名 Stem cells in development and disease [electronic resource] / edited by Michael Rendl
出版項 Burlington : Elsevier Science, 2014
國際標準書號 9780123914354
book jacket
說明 1 online resource (503 pages)
text txt rdacontent
computer c rdamedia
online resource cr rdacarrier
系列 Current topics in developmental biology ; 107
Current topics in developmental biology ; 107
附註 Front Cover; Stem Cells in Development and Disease; Copyright; Contents; Contributors; Preface; Chapter One: Mechanisms of Pluripotency In Vivo and In Vitro; 1. Introduction; 2. Phases of Lineage Restriction; 3. First Lineage Specification-ICM Versus TE Cell Fate; 4. Second Lineage Specification-EPI Versus PE Cell Fate; 5. Maintenance of Early Cell Lineages-Relevance to Pluripotent Stem Cells; 6. Growth Factor Signaling Requirements in EPI-Derived Stem Cells: In Vivo Similarities and Differences; 6.1. Leukemia inhibitory factor; 6.2. Bone morphogenic protein; 6.3. Fibroblast growth factor
6.4. Wnt6.5. Activin and Nodal; 7. Concluding Remarks; Acknowledgments; References; Chapter Two: Hematopoietic Stem Cell Development: An Epigenetic Journey; 1. Introduction; 2. Principles of Epigenetic Regulation; 2.1. DNA methylation; 2.2. Covalent histone modifications; 3. Epigenetic Regulation of Hematopoiesis; 3.1. Hematopoietic development; 3.1.1. DNA methylation; 3.1.2. Histone methylation; Polycomb-repressive complexes; Other histone modifications; 3.2. Balance between maintenance of stemness in HSCs and lineage commitment; 3.2.1. DNA methylation
3.2.2. Chromatin modifications3.2.2.1. Histone modifiers; Polycomb-repressive complexes; 3.3. HSC aging; 4. Role of Epigenetic Regulators in Hematopoietic Malignancies; 5. Conclusions; Acknowledgments; References; Chapter Three: Intestinal Stem Cells and Their Defining Niche; 1. The Mammalian Small Intestine; 1.1. The intestinal epithelium; 2. Intestinal Stem Cells; 2.1. The long search for the elusive intestinal stem cells; 2.2. Assaying for adult stem cells; 2.3. CBC markers; 2.4. +4 Markers; 2.5. Stem cell markers: A specificity debate
3. Characterizing Stem Cell Behavior During Homeostasis and Disease4. Reconciling the Opposing ISC Models; 5. The Stem Cell Niche; 5.1. Concept of a niche; 5.2. ISC niche; 5.3. Stromal microenvironment; 5.4. The Paneth cell; 5.4.1. Paneth cell function; 5.5. Ablating Paneth cells in vivo; 5.6. Signaling within the niche; 6. Studying ISCs Ex Vivo; 7. Conclusion; Acknowledgments; References; Chapter Four: Epithelial Stem Cells in Adult Skin; 1. Introduction; 2. Stem Cells in the Interfollicular Epidermis; 3. Stem Cells in the Pilosebaceous Unit; 4. Stem Cells in the Sweat Gland
5. Components of Adult Stem Cell Niches in the Skin5.1. Intrinsic regulation of stem cell function; 5.2. Cell extrinsic regulation of SC function; 6. Stem Cells in Epithelial Skin Cancers; 7. Concluding Remarks; Acknowledgments; References; Chapter Five: The Mammary Stem Cell Hierarchy; 1. Introduction; 2. Identification of Adult Mouse MaSCs; 3. The Isolation of Distinct Mammary Luminal Progenitor Cells; 4. In Vivo Lineage Tracing in the Mammary Gland; 5. Evidence for the Existence of Fetal MaSCs; 6. Elucidation of a Functionally Analogous Epithelial Hierarchy in Human Breast
7. Control of MaSCs by Steroid Hormones
This new volume of Current Topics in Developmental Biology coversStem Cells in Development and Disease. The chapters provide a comprehensive set of reviews covering such topics as the mechanisms of pluripotency in vivo and in vitro, hematopoietic stem cell development, intestinal stem cells and their defining niche, epithelial stem cells in adult skin, the mammary stem cell hierarchy, satellite cells, neural stem cells of the hippocampus, lung stem and progenitor cells in tissue homeostasis and disease, spermatogonial stem cell functions in physiological and pathological conditions, the ori
Description based on print version record
鏈接 Print version: Rendl, Michael. Stem Cells in Development and Disease. Burlington : Elsevier Science, ©2014 9780124160224
主題 Stem cells
Electronic books
Alt Author Rendl, Michael
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