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書名 G protein coupled receptors. Structure / edited by P. Michael Conn
出版項 San Diego, Calif. : Academic Press/Elsevier, 2013
©2013
國際標準書號 9780123918727
0123918723
9781283971300
1283971305
book jacket
說明 1 online resource (liv, 384 pages, 12 plates) : illustrations (some color)
1 online resource (liv, 384 pages) : illustrations (some color)
text txt rdacontent
computer c rdamedia
online resource cr rdacarrier
系列 Methods in enzymology ; v. 520
Methods in enzymology ; v. 520
附註 Includes bibliographical references and indexes
Expression of GPCRs in Pichia pastoris for structural studies -- Conformational ensemble view of G protein-couples receptors and the effect of mutations and ligand binding -- Structural evolution of G-protein-coupled receptors: a sequence space approach -- Directed evolution of G-protein-coupled receptors for high functional expression and detergent stability -- The role of hydrophobic amino acids in the structure and function of the Rhodopsin family of G protein-coupled receptors -- Structure of [beta]-adrenergic receptors -- Advances in methods to characterize ligand-induced ionic lock and Rotamer toggle molecular switch in G protein-coupled receptors -- Crystallogenesis of adenosine A2A receptor-T4 lysozyme fusion protein: a practical route for the structure -- Probing GPCR structure: adenosine and P2Y nucleotide receptors -- Strategies for studying the ligand binding site of GPCRs: photoaffinity labeling of the VPAC1 receptor, a prototype of class B GPCRs -- Expression of mammalian G protein-coupled receptors in Caenorhabditis elegans -- Expression, purification, and structural analysis of intracellular C-termini from metabotropic glutamate receptors -- Unnatural amino acid mutagenesis of GPCRs using amber codon suppression and bioorthogonal labeling -- Mapping a ligand binding site using genetically encoded photoactivatable crosslinkers -- Alternative mRNA splicing of G protein-coupled receptors -- Functional residues essential for the activation of the C1 Cannabinoid receptor
Print version record
This new volume of Methods in Enzymology continues the legacy of this premier serial by containing quality chapters authored by leaders in the field. This volume covers G protein coupled receptors and includes chapters on such topics as post-translation modification of GPCR in relationship to biased agonism, structure-based virtual screening, and GPCR oligomerization in the brain. This new volume of Methods in Enzymology continues the legacy of this premier serial by containing quality chapters authored by leaders in the field. This volume covers G protein coupled receptors and includes chapters on such topics as post-translation modification of GPCR in relationship to biased agonism, structure-based virtual screening, and GPCR oligomerization in the brain
鏈接 Print version: Conn, P. Michael. G Protein Coupled Receptors : Structure. Burlington : Elsevier Science, 2013 9780123918611
主題 G proteins -- Receptors
Receptors, G-Protein-Coupled
Alt Author Conn, P. Michael
Alt Title Structure
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