MARC 主機 00000cam  2200613Ia 4500 
001    ocn162129420 
003    OCoLC 
005    20111122085744.0 
006    m        d         
007    cr cn||||||||| 
008    070802s2002    ne a    ob    000 0 eng d 
020    9780121995041 
020    0121995046 
020    9781435632004 (electronic bk.) 
020    1435632001 (electronic bk.) 
035    (OCoLC)162129420|z(OCoLC)209861927|z(OCoLC)648350089 
037    89480:89480|bElsevier Science & Technology|nhttp://
       www.sciencedirect.com 
040    OPELS|beng|cOPELS|dOCLCQ|dN$T|dYDXCP|dE7B|dOCLCQ 
049    TEFA 
050  4 RB155.8|b.A34 2002eb 
060  4 2002 H-966 
060  4 QZ 50|bA2326 2002 
082 04 616/.042|222 
245 00 Adenoviral vectors for gene therapy|h[electronic resource]
       /|cedited by David T. Curiel, Joanne T. Douglas 
260    Amsterdam ;|aBoston :|bAcademic Press,|cc2002 
300    1 online resource (xxviii, 677 p.) :|bill 
504    Includes bibliographical references 
505 0  Adenovirus Structure -- Biology of Adenovirus Cell Entry -
       - Adenovirus Replication -- Adenoviral Vector Construction
       I: Mammalian Systems -- Adenoviral Vector Construction II:
       Bacterial Systems -- Propagation of Adenoviral Vectors: 
       Use of PER. C6 Cells -- Purification of Adenovirus -- 
       Targeted Adenoviral Vectors I: Transductional Targeting --
       Targeted Adenoviral Vectors II: Transcriptional Targeting 
       -- Development of Attenuated Replication Competent 
       Adenoviruses ARCAs) for the treatment of Prostate Cancer -
       - Replication-Selective Oncolytic Adenovirus EI-Region 
       Mutants: Virotherapy for Cancer -- Innate Immune Responses
       to in Vivo Adenovirus Infection -- Humoral Immune Response
       -- Novel Methods to Eliminate the Immune Response to 
       Adenovirus Gene Therapy -- High-Capacity "Gutless" 
       Adenoviral Vectors: Technical Aspects and Applications -- 
       Xenogenic Adenoviral Vectors -- Hybrid Adenoviral Vectors 
       -- Utility of Adenoviral Vectors in Animal Models of Human
       Disease I: Cancer -- Utiltity of Adenoviral Vectors in 
       Animal Models of Human Disease II: Genetic Disease -- 
       Utility of Adenoviral Vectors in Animal Models of Human 
       Disease III: Acquired Diseases -- Testing of Adenoviral 
       Vector Gene Transfer Products: FDA Expectations -- Imaging
       Adenovirus-Medicated Gene Transfer 
520    Adenoviral Vectors for Gene Therapy provides detailed and 
       comprehensive coverage of these important therapeutic 
       agents. The topics covered in this book range from the 
       basic biology of adenoviruses, through the construction 
       and purification of adenoviral vectors, cutting-edge 
       vectorology and the use of adenoviral vectors in 
       preclinical animal models, to regulatory issues which must
       be considered prior to the initiation of human clinical 
       gene therapy trials. The broad scope of this unique volume
       provides the reader with a complete understanding of the 
       development and use of adenoviral vectors. Key Features * 
       Provides complete coverage of basic biology of 
       adenoviruses, as well as the construction, propagation and
       purification of adenoviral vectors * Introduces common 
       strategies for the development of adenoviral vectors along
       with cutting-edge methods for their improvement * 
       Demonstrates noninvasive imaging of adenovirus-mediated 
       gene transfer * Discusses utility of adenoviral vectors in
       animal disease models * Considers Federal Drug 
       Administration regulations for human clinical trials 
588    Description based on print version record 
650  0 Gene therapy 
650  0 Adenoviruses 
650  6 Thérapie génique 
650  6 Adénovirus 
650  7 HEALTH & FITNESS|xDiseases|xGenetic.|2bisacsh 
650  7 MEDICAL|xGenetics.|2bisacsh 
650  7 Adenovírus.|2larpcal 
650  7 Genes virais.|2larpcal 
650  7 Vírus de dna.|2larpcal 
650 12 Gene Therapy|xmethods 
650 22 Adenoviridae 
650 22 Genetic Vectors|xtherapeutic use 
655  4 Electronic books 
700 1  Curiel, David 
700 1  Douglas, Joanne T 
776 08 |iPrint version:|tAdenoviral vectors for gene therapy.
       |dAmsterdam ; Boston : Academic Press, c2002|z0121995046
       |z9780121995041|w(DLC)  2001098272|w(OCoLC)49780706 
856 40 |3ScienceDirect|uhttp://www.sciencedirect.com/science/book
       /9780121995041