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作者 Wang, Xinkang
書名 Translational Animal Models in Drug Discovery and Development
出版項 SAIF Zone : Bentham Science Publishers, 2012
國際標準書號 9781608054695 (electronic bk.)
book jacket
版本 1st ed
說明 1 online resource (287 pages)
text txt rdacontent
computer c rdamedia
online resource cr rdacarrier
附註 Cover -- Title -- EUL -- Contents -- Foreword -- Preface -- List of Contributors -- Chapter 01 -- Chapter 02 -- Chapter 03 -- Chapter 04 -- Chapter 05 -- Chapter 06 -- Chapter 07 -- Chapter 08 -- Chapter 09 -- Chapter 10 -- Index
Animal models of diseases play a pivotal role in drug discovery and development, not only for proof of the concept studies of efficacy, PK/PD relationship but also for drug safety assessment. Since considerable differences in variables exist between animal models and human models (such as genetics, physiology, anatomy, gene expression, heterogeneity of disease conditions, etc.), not all the preclinical models are able to represent the pathophysiological conditions in human diseases. Therefore, partly due to the lack of congruency between animal and human disease models, several proposed therapeutic agents in the past decades have been demonstrated to be effective in preclinical models but failed in clinical studies. This e-book focuses on animal models of diseases from a translational perspective and highlights the key advantages and limitations of each model described to facilitate drug discovery and development. A unique feature of the volume is that it contains a selection of details disease models in various therapeutic niches with significant unmet medical needs, including inflammation, neurological diseases, cardiovascular and metabolic diseases, and oncology. This e-book is, therefore, of considerable value to researchers and clinicians involved in drug discovery and development as well as pathology
Description based on publisher supplied metadata and other sources
Electronic reproduction. Ann Arbor, Michigan : ProQuest Ebook Central, 2020. Available via World Wide Web. Access may be limited to ProQuest Ebook Central affiliated libraries
鏈接 Print version: Wang, Xinkang Translational Animal Models in Drug Discovery and Development SAIF Zone : Bentham Science Publishers,c2012 9781608055913
主題 Animal models in research.;Medicine -- Research
Electronic books
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