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Title Drug-induced liver toxicity / edited by Minjun Chen, Yvonne Will
Imprint New York, NY : Humana Press ; Springer, [2018]
book jacket
Descript 1 online resource (xx, 667 pages) : illustrations (some color)
text txt rdacontent
computer c rdamedia
online resource cr rdacarrier
Series Methods in pharmacology and toxicology, 1557-2153
Methods in pharmacology and toxicology
Note Includes bibliographical references and index
Overview of mechanisms of drug-induced liver injury (DILI) and key challenges in DILI research / Nabil Noureddin and Neil Kaplowitz -- Detection, elimination, mitigation, and prediction of drug-induced liver injury in drug discovery / Francois Pognan -- Drug-induced liver injury (DILI) classification and its application on human DILI risk prediction / Shraddha Thakkar, Minjun Chen, Huixiao Hong, Zhichao Liu, Hong Fang, and Weida Tong -- Physicochemical properties and structural alerts / Lilia Fisk, Nigel Greene, and Russ Naven -- Quantitative structure-activity relationship models for predicting risk of drug-induced liver injury in humans / Huixiao Hong, Jieqiang Zhu, Minjun Chen, Ping Gong, Chaoyang Zhang, and Weida Tong -- Introduction to DILIsym೯ftware, a mechanistic mathematical representation of drug-induced liver injury / Christina Battista, Brett A. Howell, Scott Q. Siler, and Paul B. Watkins -- Prediction of human liver toxicity using in vitro assays : limitations and opportunities / Franck A. Atienzar and Jean-Marie Nicolas -- Use of liver-derived cell lines for the study of drug-induced liver injury / Zhen Ren, Si Chen, Baitang Ning, and Lei Guo -- Evaluation of drug-induced liver injuries (DILI) with human hepatocytes : scientific rationale and experimental approaches / Albert P. Li -- Status and use of induced pluripotent stem cells (iPSCs) in toxicity testing / Min Wei Wong, Chris S. Pridgeon, Constanze Schlott, B. Kevin Park, and Christopher E.P. Goldring -- Engineered human liver cocultures for investigating drug-induced liver injury / Chase P. Monckton and Salman R. Khetani -- Status and future of 3D cell culture in toxicity testing / Monicah A. Otieno, Jinping Gan, and William Proctor -- Reactive metabolite assessment in drug discovery and development in support of safe drug design / Axel P表ler -- In vitro assessment of mitochondrial toxicity to predict drug-induced liver injury / Mathieu Porceddu, Nelly Buron, Pierre Rustin, Bernard Fromenty, and Annie Borgne-Sanchez -- Bile salt export pump : drug-induced liver injury and assessment approaches / Ruitang Deng -- High content screening for prediction of human drug-induced liver injury / Mikael Persson -- Interpretation, integration, and implementation of in vitro assay data : the predictive toxicity challenge / Deborah S. Light, Michael D. Aleo, and J. Gerry Kenna -- Perspectives on the regulatory and clinical science of drug-induced liver injury (DILI) / Mark I. Avigan and Monica A. Mu䮯z -- Regulatory toxicological studies : identifying drug-induced liver injury using nonclinical studies / Imran Khan and Elizabeth Hausner -- Hy's law and eDISH for clinical studies / John Senior and Ted Guo -- Variability in baseline liver test values in clinical trials : challenges in enhancing drug-induced liver injury assessment in subjects with liver disease / Bereket Tesfaldet, Gyorgy Csako, Tejas Patel, Md Shamsuzzaman, and Eileen Navarro Almario -- Postmarketing surveillance of drug-induced liver injury / S. Christopher Jones, Cindy Kortepeter, and Allen D. Brinker -- Host risk modifiers in idiosyncratic drug-induced liver injury (DILI) and its interplay with drug properties / Camilla Stephens, M. Isabel Lucena, and Ra⵬ J. Andrade -- Human leukocyte antigen (HLA) and other genetic risk factors in drug-induced liver injury (DILI) / Ann K. Daly Immune mechanisms in drug-induced liver injury / Hartmut Jaeschke and Dean J. Naisbitt -- Translational and mechanistic biomarkers of drug-induced liver injury - candidates and qualification strategies / Daniel J. Antoine -- Causality assessment methods in drug-induced liver injury / Rolf Teschke and Gaby Danan -- Circulating microRNAs as novel biomarkers of drug-induced liver injury in humans / Julian Krauskopf, Jos C. Kleinjans, and Theo M. de Kok -- Systems microscopy approaches in unraveling and predicting drug-induced liver injury (DILI) / Marije Niemeijer, Steven Hiemstra, Steven Wink, Wouter den Hollander, Bas ter Braak, and Bob van de Water -- Noninvasive preclinical and clinical imaging of liver transporter function relevant to drug-induced liver injury / J. Gerry Kenna, John C. Waterton, Andreas Baudy, Aleksandra Galetin, Catherine D. G. Hines, Paul Hockings, Manishkumar Patel, Daniel Scotcher, Steven Sourbron, Sabina Ziemian, and Gunnar Schuetz
Online resource; title from PDF title page (SpringerProtocol, viewed March 21, 2018)
Link Original 1493976761 9781493976768 (OCoLC)1011188754
Subject Hepatotoxicology -- Laboratory manuals
Chemical and Drug Induced Liver Injury
Drug Evaluation
Toxicity Tests
Electronic books
Alt Author Chen, Minjun, editor
Will, Yvonne, editor
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