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Title Progranulin : methods and protocols / edited by Andrew Bateman and Hugh P. J. Bennett, Siu Tim Cheung
Imprint New York, NY : Humana Press ; Springer, c2018
book jacket
Descript 1 online resource (xiii, 363 pages) : illustrations (some color)
text txt rdacontent
computer c rdamedia
online resource cr rdacarrier
Series Methods in molecular biology, 1064-3745 ; volume 1806
Methods in molecular biology ; 1806
Note Includes bibliographical references and index
Brief overview of progranulin in health and disease / Andrew Bateman, Siu Tim Cheung, and Hugh P. J. Bennett -- Chromatographic methods for the purification of granulin peptides / Andrew Bateman, Babykumari P. Chitramuthu, and Hugh P. J. Bennett -- Methods for expression and purification of biologically active recombinant progranulin / Chun Yu Zhao and Andrew Bateman -- Large-scale generation of recombinant granulin peptides in E. coli / Dmitri Tolkatchev -- Nuclear magnetic resonance spectroscopy in analysis of granulin three-dimensional structure and cysteine bridging / Dmitri Tolkatchev -- Data mining : applying the AD&FTD mutation database to progranulin / Marc Cruts and Christine Van Broeckhoven -- Measurement of circulating progranulin (PGRN/GP88/GEP) by enzyme-linked immunosorbent assay and application in human diseases / Ginette Serrero and David Hicks -- Immunohistochemical detection of progranulin (PGRN/GP88/GEP) in tumor tissues as a cancer prognostic biomarker / Ginette Serrero and David Hicks -- Analysis of progranulin-mediated Akt and MAPK activation / Shi-Qiong Xu, Simone Buraschi, Ryuta Tanimoto, Manuela Stefanello, Antonino Belfiore, Renato V. Iozzo, and Andrea Morrione -- Mouse monoclonal antibodies against progranulin (PGRN/GEP) as therapeutics in preclinical cancer models / Chi Wai Yip, Phyllis F. Y. Cheung, Nicholas C. L. Wong, Sze Wai Fung, and Siu Tim Cheung -- Methods to analyze the role of progranulin (PGRN/GEP) on cancer stem cell features / Phyllis F. Y. Cheung and Siu Tim Cheung -- Methods to study the role of progranulin in the tumor microenvironment / Moshe Elkabets and Samuel Brook -- Methods to investigate the molecular basis of progranulin action on neurons in vivo using Caenorhabditis elegans / James Julian Doyle and J. Alex Parker -- Use of Caenorhabditis elegans to study progranulin in the regulation of programmed cell death and stress response / Tsung-Yuan Hsu, Victoria J. Butler, and Aimee W. Kao -- Application of zebrafish and knockdown technology to define progranulin neuronal function / Babykumari P. Chitramuthu and Hugh P. J. Bennett -- Methods to investigate the molecular basis of progranulin actions on brain and behavior in vivo using knockout mice / Jan Boddaert, Hans Wils, and Samir Kumar-Singh -- Methods to investigate the protection against neurodegenerative disorders provided by progranulin gene transfer in the brain / Jackalina M. Van Kampen -- Interaction between progranulin with sortilin and the lysosome / Xiaolai Zhou, Peter M. Sullivan, Daniel H. Paushter, and Fenghua Hu -- Methods to study the role of progranulin in preimplantation mouse embryo development / Laura Diaz-Cueto, Fabian Arechavaleta-Velasco, and George L. Gerton -- Establishment of a modified collagen-induced arthritis mouse model to investigate the anti-inflammatory activity of progranulin in inflammatory arthritis / Jian-Lu Wei and Chuan-Ju Liu -- Methods for studying the function of progranulin in atherosclerosis using both knockout mice models and in vitro studies / Tohru Ohama, Ryota Kawase, Yasushi Sakata, and Shizuya Yamashita -- Methods to investigate the roles of progranulin in angiogenesis using in vitro strategies and transgenic mouse models / Huishi Toh, Eugene Daniels, and Andrew Bateman
Online resource; title from PDF title page (SpringerProtocols, viewed June 29, 2018)
Link Print version: Progranulin : methods and protocols 9781493985579 (OCoLC)1028944635
Subject Glycoproteins
Laboratory Manuals
Electronic books
Alt Author Bateman, Andrew, editor
Bennett, Hugh P. J., editor
Cheung, Siu Tim, editor
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