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Title Transient receptor potential canonical channels and brain diseases / edited by Yizheng Wang
Imprint Dordrecht : Springer Netherlands : Imprint: Springer, 2017
book jacket
Descript 1 online resource (viii, 165 pages) : illustrations, digital ; 24 cm
text txt rdacontent
computer c rdamedia
online resource cr rdacarrier
text file PDF rda
Series Advances in experimental medicine and biology, 0065-2598 ; volume 976
Advances in experimental medicine and biology ; volume 976
Note TRP channel classification -- TRPC channel structure and properties -- TRPC channel downstream signaling cascades -- TRPC Channels in Health and Disease -- TRPC channels and programmed cell death -- TRPC channels and stroke -- TRPC channels and Alzheimer's disease -- TRPC channels and Parkinson's disease -- TRPC channels and neuron development, plasticity and activities -- TRPC channels and brain inflammation -- TRPC channels and Epilepsy -- TRPC channels and mental disorders -- TRPC channels and cell proliferation -- TRPC channels and glioma
This book discusses the latest findings on the physiological and pathological functions of transient receptor potential canonical/classical (TRPC) proteins in the brain. In addition to reviewing the functions of TRPCs in brain development and neuron transmission, it mainly covers the potential roles of TRPCs in brain disorders. TRPC proteins belong to the TRP channel superfamily, which has around 30 members. Just like TRP channels, TRPCs are non-selectively permeable to cations, with a selectivity of calcium over sodium that varies among different members. The TRPC subfamily consists of six members, grouped on the basis of the similarities in gene sequence and protein structure in mammalians. What sets TRPCs apart from other subfamilies in TRPs is that their activation, stimulated by a membrane receptor-phospholipid C (PLC) cascade, contributes to the slow and sustained elevation of intracellular free calcium. Calcium ions, one of the most important types of second messengers, mediate a variety of physiological functions in the brain, including progenitor cell proliferation, dendritic formation, synaptic transmission and neuronal survival. All TRPCs except TRPC7 have been found in various regions of the brain, including the cerebrum, cerebellum, forebrain and hippocampus. This book provides students and investigators with comprehensive information on the regulation, function and potential of TRPCs and brain diseases in order to attract more attention to this field
Host Item Springer eBooks
Subject Brain -- Diseases
TRP channels
Brain -- Pathophysiology
Biochemistry, general
Cancer Research
Alt Author Wang, Yizheng, editor
SpringerLink (Online service)
Alt Title TRPC channels and brain diseases
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