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書名 Hepatitis B virus and liver disease / Jia-Horng Kao, Ding-Shinn Chen, editors
出版項 Singapore : Springer, 2018
©2018
國際標準書號 9789811048425
book jacket
館藏地 索書號 處理狀態 OPAC 訊息 條碼
 生命科學圖書館  QW170 K16h 2018    在架上    30150100425963
說明 xvii, 360 pages : illustrations ; 25 cm
text rdacontent
unmediated rdamedia
volume rdacarrier
附註 Includes index
Intro; Foreword; Preface; Contents; List of Contributors; 1: Molecular Virology andだLife Cycle; 1 Classification; 2 Structure ofだtheだHepatitis B Virus; 2.1 Viral andだSubviral Particles; 2.2 Genome Organization andだViral Proteins; 2.2.1 Pol ORF; 2.2.2 Pre-C/C ORF; HBc Protein; HBe Protein; 2.2.3 Pre-S/S ORF; SHBs; MHBs; LHBs; 2.2.4 X ORF; 3 Viral Life Cycle; 3.1 Attachment andだPenetration; 3.2 Conversion ofだGenomic RC DNA into cccDNA andだTranscriptional Activation ofだtheだViral Minichromosome; 3.3 Genomic Replication via Reverse Transcription
3.4 Virion Assembly andだRelease4 Variant Viruses; 4.1 Precore Mutants; 4.2 Basal Core Promoter Mutants; 4.3 Polymerase Mutants; 4.3.1 l-Nucleoside Analogue Resistance; 4.3.2 Acyclic Nucleoside Phosphonate Resistance; 4.3.3 d-Cyclopentane Resistance; 4.3.4 Multidrug Resistance; 4.4 Envelope Mutants; References; 2: Unmet Needs inだBasic Research: InだVitro andだInだVivo Models; 1 Introduction; 1.1 Hepatitis B Virus; 1.2 Woodchuck Hepatitis Virus; 1.3 Duck Hepatitis B Virus; 2 HBV InだVivo Experimental Models; 2.1 Chimpanzee Model; 2.2 Macaque Model; 2.3 Tupaia Model
2.4 Transgenic Mice2.5 Human Hepatocyte Chimeric Mice; 2.6 Immune-Competent Mouse Models; 2.7 Hydrodynamic Injection HBV Mouse Model; 2.8 Adenovirus-Mediated Delivery; 3 HBV InだVitro Experimental Systems; 3.1 Primary Human Hepatocytes; 3.2 HepG2 Cells; 3.3 HepaRG Cells; 3.4 HepCHLine-4 Cells; 3.5 Identification ofだtheだHBV Receptor; 3.6 NTCP Expression asだaだLimiting Factor forだHBV Infection; 3.7 NTCP-Expressing Cell Lines; 3.8 Human Hepatocytes Isolated fromだHumanized Mice; 3.9 Improvements toだPrimary Hepatocyte Culturing
3.10 Hepatic Cell Lines Derived fromだHuman-Induced Pluripotent Stem CellsReferences; 3: Immunopathogenesis ofだHepatitis BだVirus (HBV) Infection; 1 Characteristics ofだImmune Response inだAcute-Resolved HBV Infection; 1.1 The Innate Immune Response; 1.1.1 HBV: Is It Sensed or Not by theだInnate Immune System?; 1.1.2 NK Cells: TheだMain Force ofだInnate Immunity; 1.2 The Adaptive Immune Response; 1.2.1 B Cells; 1.2.2 T Cells; 2 Specialties ofだtheだImmune Response inだChronic HBV Infection; 2.1 The Innate Immune Response inだCHB; 2.2 The Adaptive Immune Response inだCHB
2.2.1 B Cells2.2.2 T Cells: Functional Exhaustion; 3 Immune Response andだLiver Injury; 3.1 HBV-Specific T Cells; 3.2 Non-HBV-Specific Cells; 4 Immune Response andだAntiviral Treatment; References; 4: Epidemiology andだNatural History ofだChronic Hepatitis B Virus Infection; 1 Introduction; 2 Epidemiology; 2.1 CHB inだAfrica; 2.2 CHB inだAsia andだtheだPacific Islands; 2.3 CHB inだtheだAmericas; 2.4 CHB inだEurope; 3 HBV Genotypes; 4 Natural History; 5 Interpretation ofだSerologies; 6 HBV Structure andだReplication Cycle; 7 Phases ofだInfection; References
This book provides a comprehensive, state-of-the art review of HBV infection and liver disease. It discusses new data on basic and translational medicine, including the viral life cycle, the immunopathogenesis of virus-induced chronic hepatitis, viral and host genetic factors affecting disease progression, and the mechanism of virus-induced hepatocarcinogenesis, as well as their potential applications in daily clinical practice. The clinical aspects of chronic HBV infection are examined in chapters on the global epidemiology, efficacy of HBV vaccination, natural history, co-infections with HCV, HDV or HIV, and management of special populations including children, pregnant women and patients undergoing immunosuppressive therapy. Further, it describes the advances and perspectives in the development of novel antiviral treatments as possible cures for HBV infection. The book is a valuable resource for medical students, physicians, and researchers who are interested in management of patients with chronic HBV infection and investigation HBV infection
鏈接 Online edition : Hepatitis B virus and liver disease 9789811048432 9811048436
主題 Hepatitis B virus
Liver -- Diseases
Alt Author Kao, Jia-Horng, editor
Chen, Ding-Shinn, editor
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