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書名 Metals in the brain : measurement and imaging / edited by Anthony R. White
出版項 New York, NY : Humana Press imprint is published by Springer Nature, [2017]
國際標準書號 9781493969180
國際標準號碼 10.1007/978-1-4939-6918-0
book jacket
說明 1 online resource (xii, 270 pages) : illustrations (some color)
text txt rdacontent
still image sti rdacontent
computer c rdamedia
online resource cr rdacarrier
text file PDF rda
系列 Neuromethods, 1940-6045 ; 124
Neuromethods ; 124
附註 Includes bibliographical references and index
Introduction and overview / Anthony R. White -- X-ray microscopy for detection of metals in the brain / Joanna F. Collingwood and Freddy Adams -- Imaging metals in the brain by laser ablation-inductively coupled plasma-mass spectrometry / Dominic J. Hare, Bence Paul, and Philip A. Doble -- Fluorescent probes for the analysis of labile metals in brain cells / Jacek L. Kolanowski, Clara Shen, and Elizabeth J. New -- Probing biological trace metals with fluorescent indicators / Christoph J. Fahrni, Daisy Bourassa, and Ryan Dikdan -- Microdissection of alzheimer brain tissue for the determination of focal manganese accumulation / Marcus W. Brazier -- Analysis of trace elements and metalloproteins in fractionated human brain samples using size exclusion inductively coupled mass spectrometry / Adam P. Gunn and Blaine R. Roberts -- Size fractionation of metal species from serum samples for studying element biodistribution in alzheimer's disease / Ra⵬ Gonz⡬ez-Dom⩮guez -- Lead uptake and localization in glial cell cultures / Rola Barhoumi, Robert Taylor, and Evelyn Tiffany-Castiglioni -- Evaluating iron flux in the brain / Bruce X. Wong, Linh Q. Lam, Andrew Tsatsanis, and James A. Duce -- Current methods used to probe and quantify intracellular total and free Zn(II) dynamics, and subcellular distribution in cultured neurons / Yan Qin, Kyle R. Gee, Qiaoling Jin, Barry Lai, Cheng Qian, and Robert A. Colvin -- Monitoring intracellular Zn2+ using fluorescent sensors : facts and artifacts / Lech Kiedrowski -- Measuring changes in brain manganese or iron using magnetic resonance imaging (MRI) / Kimberly L. Desmond and Nicholas A. Bock -- Treatment and measurement of metals in brain cell cultures / Xin Yi Choo and Alexandra Grubman
"Our understanding of how metals contribute to neural cell function and disease in the brain is rapidly evolving. A broad range of metals occur in the brain, from trace levels through to bulk amounts. Methods for measuring levels of metals and imaging metal localization are diverse and often prone to pitfalls associated with a lack of experience in the factors that affect metal detection. These include use of non-physiological metal treatments, fixation artifacts in tissues, mis-interpretation of data from metal-probes, and mis-understanding of the sensitivity and/or specificity of many techniques. This book is designed to bring together a well-considered selection of methods used by experienced metal researchers to aid investigators in their plans to examine metal levels or distribution in brain tissue or brain-derived cells and avoid many of the pitfalls that can lead to nonreproducible and artifact-prone data. The chapters following this introduction will provide a broad and where necessary in-depth coverage of the leading approaches used today for assessment of metal levels in brain, brain-derived cells, and in some cases serum (which can be used to provide important collorary information on neural metal levels). Subsequent chapters provide a more focused examination of the methodology and issues associated with measuring some of the more commonly studied brain metals. It is hoped that whether researchers read all the chapters or just a selection targeting their metal or technique of interest, they can take away important new insights to provide accurate and reproducible metal measurement relevant to brain tissue. These improvements will help the field to establish and maintain metal regulation as a critical aspect of brain function in health and disease"--Introduction
Description based on online resource; title from pdf title page (SpringerLink, viewed April 10, 2017)
鏈接 Print version: Metals in the brain. New York, NY : Humana Press imprint is published by Springer Nature, [2017] 9781493969166 (DLC) 2017937544 (OCoLC)966594594
主題 Brain -- Metabolism
Brain -- Effect of metals on
Brain chemistry
Brain -- Imaging
Medical -- Neurology
Brain -- diagnostic imaging
Brain -- metabolism
Metals -- metabolism
Electronic books
Alt Author White, Anthony R., editor
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