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書名 Safety and efficacy of gene-based therapeutics for inherited disorders / edited by Nicola Brunetti-Pierri
出版項 Cham : Springer International Publishing : Imprint: Springer, 2017
國際標準書號 9783319534572 (electronic bk.)
9783319534558 (paper)
國際標準號碼 10.1007/978-3-319-53457-2 doi
book jacket
說明 1 online resource (ix, 220 pages) : illustrations, digital ; 24 cm
text txt rdacontent
computer c rdamedia
online resource cr rdacarrier
text file PDF rda
附註 Overview: gene transfer strategies, principles, applications -- Manufacturing viral gene therapy vectors: general approaches and challenges -- Retrovirus- and lentivirus-based vectors -- Preclinical and clinical applications of retroviral vectors -- Preclinical and clinical applications of lentiviral vectors -- Retrovirus and lentivirus integration -- Adenovirus-based vectors for gene therapy -- Adenoviral vector-host interactions -- Helper-dependent adenoviral vectors -- Gene therapy for cancer treatment -- Oncolytic adenoviruses for cancer treatment -- Vaccination by gene transfer vectors -- AAV vectors: general features and applications -- Adaptive immune response to viral vector delivery -- Herpes viruses: general features and applications -- RNA interference-based strategy for treatment of human diseases -- Antisense oligonucleotide based therapeutics -- Gene editing strategies -- Nonviral vectors
In this book, leading international experts analyze state-of-the-art advances in gene transfer vectors for applications in inherited disorders and also examine the toxicity profiles of these methods. The authors discuss the strengths and weaknesses of available vectors in the clinical setting, and specifically focus on the challenges and possible solutions that researchers are testing in order to improve the safety of gene therapy for genetic diseases. This comprehensive and authoritative overview of vector development is a necessary text for researchers, toxicologists, pharmacologists, molecular biologists, physicians, and students in these fields
Host Item Springer eBooks
主題 Genetic disorders -- Gene therapy
Genetic transformation
Biomedicine
Pharmacology/Toxicology
Gene Therapy
Molecular Medicine
Alt Author Brunetti-Pierri, Nicola, editor
SpringerLink (Online service)
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