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書名 Essential and non-essential metals : carcinogenesis, prevention and cancer therapeutics / edited by Anuradha Mudipalli, Judith T. Zelikoff
出版項 Cham : Springer International Publishing : Imprint: Humana Press, 2017
國際標準書號 9783319554488 (electronic bk.)
9783319554464 (paper)
國際標準號碼 10.1007/978-3-319-55448-8 doi
book jacket
說明 1 online resource (xii, 228 pages) : illustrations (some color), digital ; 24 cm
text txt rdacontent
computer c rdamedia
online resource cr rdacarrier
text file PDF rda
系列 Molecular and integrative toxicology, 2168-4219
Molecular and integrative toxicology
附註 Calcium channels and pumps important during lactation as potential targets for breast cancer -- Tumor development through the Mg2+nifying glass -- Selenium: roles in cancer prevention and therapies -- Zinc and Zinc-Dependent Proteins in Cancer adn Chemotherapeutics -- Arsenic Carcinogenesis -- Cadmium Carcinogenesis and Mechanistic Insights -- Molecular Mechanisms of Chromium-Induced Carcinogenesis -- Mechanisms of Nickel Carcinogenesis -- Application of Metallomics and Metalloproteomics for Understanding the Molecular Mechanisms of Action of Metal-based Drugs
This book aims to present current state of understanding of the role of metals in human health and disease. As it will be difficult to cover all of the metals, about two scores of them, the authors will instead provide a detailed analysis of a select set of essential (Calcium, Magnesium, Selenium, Iron, copper and Zinc) and non-essential metals (Nickel, Chromium, Cadmium and Arsenic, Tungsten and Asbestos) Each chapter will have a dedicated section focusing on the binary role that some of these metals play, their carcinogenic and cancer therapeutics, by integrating epidemiological, experimental evidence with special emphasis and focus on molecular mechanisms involved in these processes. The biological analysis will also include emerging lines of evidence such as micro RNAS, kinase families, receptors, endoplasmic, mitochondrial players and epigenetics. As part of integrating the human, experimental and mechanistic data, as well as a detailed analysis into the modes of action for different cancer outcomes will be discussed in each chapter wherever deemed feasible. These approaches are ones in which no other book in this area has attempted to do
Host Item Springer eBooks
主題 Chemical carcinogenesis
Metals -- Physiological effect
Metals -- Therapeutic use
Cancer Research
Molecular Medicine
Alt Author Mudipalli, Anuradha, editor
Zelikoff, Judith T., editor
SpringerLink (Online service)
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