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書名 Cellular osmolytes : from chaperoning protein folding to clinical perspectives / edited by Laishram Rajendrakumar Singh, Tanveer Ali Dar
出版項 Singapore : Springer Singapore : Imprint: Springer, 2017
國際標準書號 9789811037078 (electronic bk.)
9789811037061 (paper)
國際標準號碼 10.1007/978-981-10-3707-8 doi
book jacket
說明 1 online resource (vii, 249 pages) : illustrations, digital ; 24 cm
text txt rdacontent
computer c rdamedia
online resource cr rdacarrier
text file PDF rda
附註 Polyols as exceptional Protein stabilizers -- Osmolyte mixtures versus individuals in protein folding and aggregation -- Molecular insights of Osmolyte-protein Interaction -- MDS simulation studies on osmolyte protein interactions -- Osmolytes as protein aggregation Modifiers -- Osmolytes as Nano-probes of conformational changes -- Inhibition of Protein fibrillation by Chemical chaperones: a Therapeutic strategy -- Osmolyte in Infectious Diseases -- Possible strategies for the therapeutic intervention of osmolyte in Cancer -- Antioxidant osmolytes -- Advances on the in vivo studies of the effect of osmolyte on various pathophysiological conditions -- TMAO in alpha Synuclein aggregation -- Osmolytes: from cell physiology to Disease Prevention -- Osmolytes in Cell-volume Regulation -- Role of Osmolytes in counteracting the deleterious effects of denaturant/pressure
This book provides essential insights into improving protein folding/stability, which is a result of the balance between the intra-molecular interactions of protein functional groups and their interactions with the solvent environment. Even a subtle change in the composition of the solvent environment will alter the fidelity of the protein folding process, and hostile environmental stresses represent one of the basic causes of challenges in protein folding or misfolding. Among the strategies employed in a wide range of species and cell types to circumvent the hostile environmental conditions is the elaboration of small organic molecules called osmolytes, and recent advances have revealed that certain specific osmolytes might be key biomarkers of cancer, infectious diseases and are useful in heterologous protein expression and vaccine flocculation. As such a large pool of data has been collected regarding their potential for therapeutic intervention in neurodegenerative diseases and other metabolic disorders caused by protein aggregation or proteiostasis failure
Host Item Springer eBooks
主題 Molecular chaperones
Protein folding
Biomedicine
Biomedical Engineering/Biotechnology
Cell Physiology
Protein-Ligand Interactions
Cancer Research
Animal Biochemistry
Plant Biochemistry
Alt Author Singh, Laishram Rajendrakumar, editor
Dar, Tanveer Ali, editor
SpringerLink (Online service)
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