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書名 Environmental Factors in Neurodegenerative Diseases / edited by Michael Aschner, Lucio G. Costa
出版項 Cambridge : Academic Press, 2017
國際標準書號 9780128127643
0128127643
book jacket
說明 1 online resource (xi, 278 pages : illustrations)
text txt rdacontent
computer c rdamedia
online resource cr rdacarrier
系列 Advances in neurotoxicology ; 1
附註 Text in English
2.3. Exposure Assessment and Studies of Specific Pesticides2.3.1. Rotenone; 2.3.2. Paraquat; 2.3.3. Organochlorine Pesticides; 2.3.4. Specific Organochlorines; 2.3.5. Other Pesticide Associations; 2.4. Studies of Interaction Between Genes and Environment; 3. Experimental Evidence; 3.1. Pesticides and Nigrostriatal Degeneration: Rotenone and Paraquat; 3.1.1. Rotenone; 3.1.2. Paraquat; 3.2. Rotenone, Paraquat, and [alpha]-Synuclein; 3.2.1. [alpha]-Synuclein and Rotenone; 3.2.2. [alpha]-Synuclein and Paraquat; 3.3. Additional Features of PD-Relevant Pesticides
Front Cover; Environmental Factors in Neurodegenerative Diseases; Copyright; Contents; Contributors; Preface; Chapter One: Traffic-Related Air Pollution and Neurodegenerative Diseases: Epidemiological and Experimental Evidence, and ... ; 1. Introduction; 2. The CNS as a Target for Air Pollution Toxicity; 2.1. Neurotoxicity in Adults: Epidemiological and Animal Studies; 2.2. Developmental Neurotoxicity; 3. Air Pollution and Neurodegenerative Diseases; 3.1. Air Pollution and PD; 3.2. Air Pollution and Amyotrophic Lateral Sclerosis; 3.3. Air Pollution and Multiple Sclerosis
3.4. Air Pollution and Alzheimer's Disease and Other Dementias4. Possible Mechanisms Linking Air Pollution to Neurodegeneration; 4.1. Adult Neurogenesis; 4.2. MicroRNAs; 4.3. Telomere Length; 4.4. Reelin; 4.5. Glutamate; 5. Conclusion and Research Needs; Acknowledgments; References; Further Reading; Chapter Two: The Catecholaminergic Neurotransmitter System in Methylmercury-Induced Neurotoxicity; 1. Introduction; 2. The Catecholaminergic Neurotransmitter System: General Aspects; 3. Catecholamines in Neurological and Neuropsychiatric Disorders
4. The Catecholaminergic Neurotransmitter System as a Potential Target of Neurotoxicants and Related Consequences5. Methylmercury: General Aspects and Major Mechanisms of Neurotoxicity; 6. Methylmercury-Mediated Catecholaminergic Toxicity; 6.1. Dopamine; 6.2. Epinephrine; 7. Concluding Remarks; Acknowledgments; References; Further Reading; Chapter Three: Pesticides and Parkinson's Disease: Current Experimental and Epidemiological Evidence; 1. Introduction; 2. Epidemiological Evidence; 2.1. Studies of Occupations; 2.2. Studies of Exposure to Pesticides
3.3.1. Long-Lasting Effects and Toxicant Interactions3.3.2. Gender Differences and Genetic Determinants of Pesticide Neurotoxicity; 3.3.3. Pesticide-Induced Transcriptional Alterations; 4. Final Remarks; Acknowledgment; References; Chapter Four: Metals and Circadian Rhythms; 1. Introduction; 2. Manganese; 3. Copper; 4. Zinc; 5. Lead; 6. Mercury; 7. Aluminum; 8. Conclusion; Acknowledgments; References; Chapter Five: Aluminum and Neurodegenerative Diseases; 1. Introduction; 2. Growing Bioavailability of Aluminum in the Environment
Environmental Factors in Neurodegenerative Diseases, Volume One addresses contemporary advances in neurotoxicology, with thematic volumes providing authoritative review articles on key issues in the field. Updates in this new volume include chapters on Air pollution and neurodegenerative diseases, Mercury and Parkinson's disease, Pesticides and PD: current evidence, Aluminum and neurodegeneration, Microglia and neurodegeneration, Dietary factors, Mitochondria in neurodegeneration, and Manganese and neurodegeneration. Edited by leading experts, volumes are designed as in-depth overviews of the latest topic developments that analyze the effect of varied chemical agents on the nervous system. It is an essential resource for researchers and graduate students alike
鏈接 Print version: 9780128127643 0128127643 (OCoLC)985078857
主題 Nervous system -- Degeneration
Nervous system -- Diseases -- Environmental aspects
Neurotoxicology
Neurodegenerative Diseases
Electronic books
Alt Author Aschner, Michael, 1955- editor
Costa, Lucio G., 1954- editor
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