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書名 Thyroid Hormone / series editor, Gerald Litwack
出版項 Cambaridge, MA, United States : Academic Press, 2018
國際標準書號 9780128141175
0128141174
9780128141168
0128141166
book jacket
版本 First edition
說明 1 online resource (xx, 544 pages : illustrations)
text txt rdacontent
computer c rdamedia
online resource cr rdacarrier
系列 Vitamins and hormones ; volume 106
Vitamins and hormones ; 106
附註 Text in English
Includes bibliographical references
Thyroid Hormone Receptor Antagonists: From Environmental Pollution to Novel Small Molecules Louise S. Mackenzie 8. Thyroid Hormone Stimulation of Adult Brain Fatty Acid Oxidation Mikaela M. Sifuentes and James D. Lechleiter 9. The NF--[kappa]B Family of Transcription Factors and Its Role in Thyroid Physiology Carla Reale, Tiziana Zotti, Ivan Scudiero, Pasquale Vito and Romania Stilo 10. Thyroid Hormone Regulation of Adult Neurogenesis Sashaina E. Fanibunda, Lynette A. Desouza, Richa Kapoor, Rama A. Vaidya and Vidita A. Vaidya 11. Thyroid Hormone and the White Matter of the Central Nervous System: From Development to Repair Laura Calzᡬ Vito A. Baldassarro, Mercedes Fernandez, Alessandro Giuliani, Luca Lorenzini and Luciana Giardino 12
1. Local Regulation of Thyroid Hormone Signaling Alexander G. Little 2. Thyroid Hormone Transport and Transporters Doreen Braun and Ulrich Schweizer 3. Nuclear Import and Export of the Thyroid Hormone Receptor Jibo Zhang, Vincent R. Roggero and Lizabeth A. Allison 4. Molecular Basis of Nongenomic Actions of Thyroid Hormone Paul J. Davis, Jack L. Leonard, Hung-Yun Lin, Matthew Leinung and Shaker A. Mousa 5. The Mechanism of Negative Transcriptional Regulation by Thyroid Hormone: Lessons From the Thyrotropin [Beta] Subunit Gene Shigekazu Sasaki, Akio Matsushita, Go Kuroda, Hiroko M. Nakamura, Yutaka Oki and Takafumi Suda 6. Thyroid Autoimmunity: An Interplay of Factors Stephen J. Merrill and Sarah B. Minucci 7
Front Cover; Thyroid Hormone; Copyright; Former Editors; Contents; Contributors; Preface; Chapter One: Local Regulation of Thyroid Hormone Signaling; 1. Introduction; 2. Bioavailability; 2.1. TH Transporters; 2.2. Deiodinases; 2.3. Intracellular Reservoir Proteins; 3. Bioactivity; 3.1. Thyroid Receptors; 3.2. Integrin ㉫v䁣x9F;3; 3.3. Thyroid Response Elements; 4. Conclusions; References; Further Reading; Chapter Two: Thyroid Hormone Transport and Transporters; 1. Introduction; 2. Thyroid hormone Transport; 3. Monocarboxylate Transporter 8; 3.1. The Syndrome of Inherited MCT8 Deficiency
3.2. Mutations in MCT8 Impair Thyroid Hormone Transport3.3. Concepts for Treatment of MCT8 Deficiency; 3.3.1. Raising Low T4; 3.3.2. Lowering Elevated T3; 3.3.3. Replacing Thyroid Hormone With an MCT8-Independent Agonist; 4. Mouse Models of Allan-Herndon-Dudley Syndrome; 5. Thyroid Hormone Transport and Physiology; 6. Further Clinical Implications for Thyroid Hormone Transporters; 6.1. Polymorphisms in Thyroid Hormone Transporters May Affect Thyroid Hormone Levels; 6.2. Inhibition of Thyroid Hormone Transport by Drugs; 6.3. Intestinal Uptake of T4 and Thyroid Hormone Transport
7. Conclusions and Future DirectionsAcknowledgments; References; Chapter Three: Nuclear Import and Export of the Thyroid Hormone Receptor; 1. Introduction; 2. Thyroid Hormone Receptor Nucleocytoplasmic Shuttling; 2.1. Translocation Through the Nuclear Pore Complexes; 2.2. Analysis of Nucleocytoplasmic Shuttling in Live Cells; 3. Nuclear Import Pathways of TR; 3.1. NLSs in TR㉫1; 3.1.1. Hinge Domain NLS; 3.1.2. A/B Domain NLS; 3.2. Importins That Mediate TR㉫1 Nuclear Import; 3.2.1. Importin ㉫1/䁣x9F;1 Heterodimer; 3.2.2. Importin 7; 4. Nuclear Export Pathways of TR㉫1; 4.1. NESs in TR㉫1
4.1.1. NES-H124.1.2. NES-H3 and NES-H6; 4.2. Exportins That Mediate TR㉫1 Nuclear Export; 4.2.1. CRM1; 4.2.2. Exportins 4, 5, and 7; 5. Mislocalization of TR and Pathogenesis; 5.1. TR Mislocalization and Cancer; 5.2. TR Mislocalization and RTH Syndrome; 6. Conclusions and Future Directions; Acknowledgments; References; Chapter Four: Molecular Basis of Nongenomic Actions of Thyroid Hormone; 1. Introduction; 2. Regulation of the State of the Cytoskeleton by Thyroid Hormone; 3. Regulation of Mitochondrial Respiration by Thyroid Hormone
4. Nongenomic Actions of Truncated and Intact TRs in Cytoplasm on Bone Cells, Neurons, and Tumor Suppression5. Cytoplasmic Proteins in Addition to TRs That Mediate Nongenomic Actions of Thyroid Hormone; 6. Nongenomic Actions of Thyroid Hormone Initiated at Plasma Membrane; 7. Thyroid Hormone Receptor on Plasma Membrane Integrin ㉫v䁣x9F;3; 8. Thyroid Hormone ㉫v䁣x9F;3 Receptor and Angiogenesis; 9. Thyroid Hormone ㉫v䁣x9F;3 Receptor and Tumor Cell Proliferation; 10. Thyroid Hormone ㉫v䁣x9F;3 Receptor and Regulation of Gene Expression; 11. Thyroid Hormone ㉫v䁣x9F;3 Receptor and Cell Physiology; 12. Discussion
Thyroid hormone, Volume 106, the latest release in the Vitamins and Hormones series first published in 1943 provides up-to-date information on crystal structures and basic structural studies on neurotrophins and their receptors, neurotrophin functions and the biological actions of neurotrophins related to clinical conditions and disease. This new release focuses on timely topics, including the Nuclear Import and Export of the Thyroid Hormone Receptor, the Thyroid hormone and the white matter of the central nervous system: from development to repair, Thyroid hormone and astrocyte differentiation, and the Molecular Basis of Nongenomic Actions of Thyroid Hormone, amongst other topics
鏈接 Print version: 0128141166 9780128141168 (OCoLC)994360317
主題 Thyroid hormones
MEDICAL / Physiology. bisacsh
SCIENCE / Life Sciences / Human Anatomy & Physiology. bisacsh
Thyroid hormones. fast (OCoLC)fst01150595
Thyroid Hormones
Electronic books
Alt Author Litwack, Gerald, editor
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