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書名 Emerging concepts targeting immune checkpoints in cancer and autoimmunity / edited by Akihiko Yoshimura
出版項 Cham : Springer International Publishing : Imprint: Springer, 2017
國際標準書號 9783319689296 (electronic bk.)
9783319689289 (paper)
國際標準號碼 10.1007/978-3-319-68929-6 doi
book jacket
說明 1 online resource (viii, 267 pages) : digital ; 24 cm
text txt rdacontent
computer c rdamedia
online resource cr rdacarrier
text file PDF rda
系列 Current topics in microbiology and immunology, 0070-217X ; volume 410
Current topics in microbiology and immunology ; volume 410
附註 Regulatory T cells: molecular and cellular basis for immunoregulation -- Overview of LAG-3- expressing, IL-10-producing regulatory T cells -- Regulatory Dendritic Cells -- Role of PD-1 in immunity and diseases -- CTLA-4, an essential immune-checkpoint for T cell activation -- Tim-3, Lag-3, and TIGIT -- SOCS1: regulator of T cells in autoimmunity and cancer -- Mining the complex family of protein tyrosine phosphatases for checkpoint regulators in immunity -- Immune regulation by ubiquitin tagging as checkpoint code -- MicroRNA in Immune Regulation
This volume reviews the current state of research on immune checkpoints and offers novel concepts. It discusses the two most important immune checkpoints: T lymphocyte-associated antigen-4 (CTLA-4) and programmed cell death-1 (PD-1) It shows that antagonistic antibodies against these two molecules are highly effective in the treatment of various cancers and that PD-1 and CTLA-4 have been linked to the suppression of T-cell receptor signaling and co-stimulatory molecules. Further, the volume examines other agents, a number of cells, receptors and signaling molecules, that are also involved in the regulation of T-cell activation and extends the concept of immune checkpoints to "molecules and cells that negatively regulate T-cell activation". Playing essential roles in immune homeostasis, they could offer new targets for cancer immunotherapy, and for the therapy of autoimmune diseases. Written by internationally respected scientists, this book will appeal to basic scientists, clinicians, drug development researchers, and advanced students alike
Host Item Springer eBooks
主題 Immune response -- Regulation
Cancer -- Immunological aspects
Cancer Research
Cell Biology
Alt Author Yoshimura, Akihiko, editor
SpringerLink (Online service)
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