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Author Alford, Aaron A
Title The influence of fetal and early growth on adult mental distress: Evidence from the Johns Hopkins collaborative perinatal study birth cohort
book jacket
Descript 284 p
Note Source: Dissertation Abstracts International, Volume: 69-12, Section: B, page: 7389
Adviser: David Paige
Thesis (Ph.D.)--The Johns Hopkins University, 2009
Objectives. Early childhood physical growth may have an impact on the development of adult mental distress. The primary objectives were to (2) assess the association of early growth in weight adjusted for height with adult mental distress, and (2) determine if there are patterns of early growth that increase or decrease the likelihood of adult mental distress
Methods. Subjects were all Johns Hopkins Collaborative Perinatal Study cohort subjects with complete birth size information that successfully completed the Pathways to Adulthood follow-up in early adulthood. Variability in the timing of growth in weight adjusted for height from birth to age 7.5 years was taken into account using a nonhierarchical linear model. Two critical periods of growth were considered as tertiles of change in weight adjusted for height from birth to age seven and birth to age 1 year. Mental distress in adulthood (ages 29-32) was measured using the General Health Questionnaire (GHQ-28)
Results. Small for gestational age subjects were at increased risk of later mental distress, but not uniformly so. Those born with low weight and length for gestational age were a distinct subgroup of those born small for gestational age, and had unique patterns of risk for adult mental distress when early growth was considered
Conclusions. Acceleration and deceleration in weight for height change is associated with mental distress over multiple periods of early life and acts differentially between those periods. Furthermore, the association of early childhood growth on the likelihood of adult mental distress is dependent on prenatal growth
School code: 0098
Host Item Dissertation Abstracts International 69-12B
Subject Health Sciences, Mental Health
Health Sciences, Epidemiology
Alt Author The Johns Hopkins University
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