LEADER 00000nam a2200505 i 4500 
001    978-981-10-6583-5 
003    DE-He213 
005    20180511143536.0 
006    m     o  d         
007    cr nn 008maaau 
008    171116s2017    si      s         0 eng d 
020    9789811065835|q(electronic bk.) 
020    9789811065828|q(paper) 
024 7  10.1007/978-981-10-6583-5|2doi 
040    GP|cGP|erda 
041 0  eng 
050  4 QP551 
082 04 572.6|223 
245 00 DJ-1/PARK7 protein :|bParkinson's disease, cancer and 
       oxidative stress-induced diseases /|cedited by Hiroyoshi 
       Ariga, Sanae M. M. Iguchi-Ariga 
264  1 Singapore :|bSpringer Singapore :|bImprint: Springer,
       |c2017 
300    1 online resource (viii, 222 pages) :|billustrations, 
       digital ;|c24 cm 
336    text|btxt|2rdacontent 
337    computer|bc|2rdamedia 
338    online resource|bcr|2rdacarrier 
347    text file|bPDF|2rda 
490 1  Advances in experimental medicine and biology,|x0065-2598 
       ;|vvolume 1037 
520    This book reviews the functions and roles of DJ-1 in 
       various oxidative stress-related diseases and applications
       of DJ-1 and its binding compounds to the diseases. The DJ-
       1 gene was first found to be a novel oncogene in 1997 and 
       later, in 2003, also found to be a causative gene for a 
       familial form of Parkinson's disease (PD), park7. The DJ-
       1 gene is therefore the first gene discovered that is 
       known to cause cancer and neurodenegerative diseases, 
       including PD. The research field has expanded as the 
       research has developed. Thus this volume begins with a 
       general introduction of DJ-1, and explains the history and
       research development to understand the following chapters.
       Those chapters present the roles of DJ-1 in various 
       oxidative stress-related diseases such as 
       neurodegenerative diseases, as well as cancer, diabetes, 
       and fertility. Moreover, several chapters present evidence
       that DJ-1 is useful for therapeutic strategies against 
       these diseases. The reader will discover that DJ-1 is a 
       promising protein both for basic cell biology and for the 
       mechanism and therapy for oxidative stress-related 
       diseases 
650  0 Proteins 
650  0 Nervous system|xDegeneration|xMolecular aspects 
650  0 Cancer|xMolecular aspects 
650 14 Biomedicine 
650 24 Cancer Research 
650 24 Biochemistry, general 
650 24 Neurosciences 
650 24 Cell Biology 
700 1  Ariga, Hiroyoshi,|eeditor 
700 1  Iguchi-Ariga, Sanae M. M.,|eeditor 
710 2  SpringerLink (Online service) 
773 0  |tSpringer eBooks 
830  0 Advances in experimental medicine and biology ;|vvolume 
       1037 
856 40 |uhttp://dx.doi.org/10.1007/978-981-10-6583-5