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Title DJ-1/PARK7 protein : Parkinson's disease, cancer and oxidative stress-induced diseases / edited by Hiroyoshi Ariga, Sanae M. M. Iguchi-Ariga
Imprint Singapore : Springer Singapore : Imprint: Springer, 2017
book jacket
Descript 1 online resource (viii, 222 pages) : illustrations, digital ; 24 cm
text txt rdacontent
computer c rdamedia
online resource cr rdacarrier
text file PDF rda
Series Advances in experimental medicine and biology, 0065-2598 ; volume 1037
Advances in experimental medicine and biology ; volume 1037
Note This book reviews the functions and roles of DJ-1 in various oxidative stress-related diseases and applications of DJ-1 and its binding compounds to the diseases. The DJ-1 gene was first found to be a novel oncogene in 1997 and later, in 2003, also found to be a causative gene for a familial form of Parkinson's disease (PD), park7. The DJ-1 gene is therefore the first gene discovered that is known to cause cancer and neurodenegerative diseases, including PD. The research field has expanded as the research has developed. Thus this volume begins with a general introduction of DJ-1, and explains the history and research development to understand the following chapters. Those chapters present the roles of DJ-1 in various oxidative stress-related diseases such as neurodegenerative diseases, as well as cancer, diabetes, and fertility. Moreover, several chapters present evidence that DJ-1 is useful for therapeutic strategies against these diseases. The reader will discover that DJ-1 is a promising protein both for basic cell biology and for the mechanism and therapy for oxidative stress-related diseases
Host Item Springer eBooks
Subject Proteins
Nervous system -- Degeneration -- Molecular aspects
Cancer -- Molecular aspects
Cancer Research
Biochemistry, general
Cell Biology
Alt Author Ariga, Hiroyoshi, editor
Iguchi-Ariga, Sanae M. M., editor
SpringerLink (Online service)
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