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Author Lasch, Peter
Title Biomedical Vibrational Spectroscopy
Imprint Hoboken : John Wiley & Sons, Incorporated, 2008
©2008
book jacket
Edition 1st ed
Descript 1 online resource (403 pages)
text txt rdacontent
computer c rdamedia
online resource cr rdacarrier
Note Intro -- BIOMEDICAL VIBRATIONAL SPECTROSCOPY -- CONTENTS -- Preface -- Contributors -- 1 VIBRATIONAL SPECTROSCOPY IN MICROBIOLOGY AND MEDICAL DIAGNOSTICS -- 1.1 Vibrational Spectra in Biomedicine Provide Fingerprint-like Signatures of Biological Structures -- 1.2 Different Technical Options to Obtain the Spectral Information -- 1.3 The Need for and Benefit from Data Evaluation -- 1.4 Perspectives of Biomedical Vibrational Spectroscopy -- 2 BIOMEDICAL VIBRATIONAL SPECTROSCOPY - TECHNICAL ADVANCES -- 2.1 Introduction -- 2.2 Measurement Techniques for Clinical Chemistry -- 2.3 Measurement Techniques for Pathology -- 2.4 Measurement Techniques for In Vivo Spectroscopy -- 2.5 Concluding Remarks -- Acknowledgments -- References -- 3 BIOMEDICAL APPLICATIONS OF INFRARED MICROSPECTROSCOPY AND IMAGING BY VARIOUS MEANS -- 3.1 Introduction -- 3.2 Specimen Sources, Experimental Schemes, and Optical Substrates -- 3.3 Applications -- 3.4 Instrumental Means of Biomedical IMS -- 3.5 Comment -- Acknowledgments -- Acronyms and Trademarks -- References -- 4 INFRARED SPECTROSCOPY OF BIOFLUIDS IN CLINICAL CHEMISTRY AND MEDICAL DIAGNOSTICS -- 4.1 Introduction -- 4.2 Vibrational Spectroscopy of Biofluids -- 4.3 Quantification (Regression) and Diagnostic (Classification) Approaches -- 4.4 Quantitative Biofluid Analysis -- 4.5 Diagnostic Biofluid Tests -- 4.6 Veterinary Applications -- 4.7 Microfluidics and IR Spectroscopy of Biofluids -- 4.8 Concluding Remarks -- References -- 5 RAMAN SPECTROSCOPY OF BIOFLUIDS -- 5.1 Introduction -- 5.2 Background Fluorescence -- 5.3 The Putative Drawback of a Low Signal-to-Noise-Ratio -- 5.4 Spectroscopy of Blood and Its Derivates -- 5.5 In Vitro Raman Spectroscopy of Serum for Laboratory Diagnostics: A Case Study -- 5.6 Raman Spectroscopy of Body Fluids In Vivo -- 5.7 Raman Spectroscopy of Other Body Fluids -- 5.8 Summary
Acknowledgments -- References -- 6 VIBRATIONAL MICROSPECTROSCOPY OF CELLS AND TISSUES -- 6.1 Introduction -- 6.2 Infrared Histopathology: IR Microspectroscopic Mapping of Tissues -- 6.3 Vibrational Cytology: IR and Raman Spectroscopy of Eukaryotic Cells -- 6.4 Concluding Remarks -- Acknowledgments -- References -- 7 RESONANCE RAMAN MICROSPECTROSCOPY AND IMAGING OF HEMOPROTEINS IN SINGLE LEUKOCYTES -- 7.1 Hemoproteins -- 7.2 Raman Microspectroscopy -- 7.3 Outline of This Chapter -- 7.4 Instrumentation and Spectral Data Analysis -- 7.5 Resonance Raman Microspectroscopy on Neutrophilic Granulocytes -- 7.6 Resonance Raman Microscopy on Neutrophilic Granulocytes -- 7.7 Photobleaching and Light-Induced Cell Damage in Resonance Raman Microspectroscopy -- 7.8 Concluding Remarks -- Acknowledgments -- References -- 8 RESONANT RAMAN SCATTERING OF HEME MOLECULES IN CELLS AND IN THE SOLID STATE -- 8.1 Introduction -- 8.2 Electronic Structure of Heme Moieties -- 8.3 Resonance Raman Spectroscopy -- 8.4 Resonance Raman Spectroscopy of Hemes in Cells and the Solid State -- 8.5 Resonance Raman of Heme Derivatives Using Near-Infrared Excitation in the Solid State -- 8.6 Application to Malaria Research -- 8.7 Summary -- Acknowledgments -- References -- 9 COHERENT ANTI-STOKES RAMAN SCATTERING (CARS) MICROSCOPY -- 9.1 Introduction -- 9.2 Theoretical Considerations -- 9.3 CARS Microscopy -- 9.4 Suppression of the Nonresonant Background -- 9.5 Applications to Biology -- 9.6 Outlook -- Acknowledgments -- References -- 10 SURFACE-ENHANCED RAMAN SENSORS FOR METABOLIC ANALYTES -- 10.1 Background -- 10.2 Experimental Setup -- 10.3 Results and Discussion -- 10.4 Conclusion -- Acknowledgments -- References -- 11 SURFACE-ENHANCED RAMAN SCATTERING FOR INVESTIGATIONS OF EUKARYOTIC CELLS -- 11.1 Motivation: SERS and Cell Studies -- 11.2 Probing Intrinsic Cellular Chemistry
11.3 SERS-Based Optical Labels for Live Cell Studies -- 11.4 Conclusions and Outlook -- Acknowledgments -- References -- 12 COMBINING OPTICAL COHERENCE TOMOGRAPHY AND RAMAN SPECTROSCOPY FOR INVESTIGATING DENTAL AND OTHER MINERALIZED TISSUES -- 12.1 Introduction -- 12.2 Optical Coherence Tomography -- 12.3 Raman Spectroscopy of Mineralized Tissues -- 12.4 Towards Clinical Dental Relevance -- 12.5 Conclusions: Our Multi Modal Approach for Evaluating Early Dental Caries -- Acknowledgments -- References -- 13 SUB-100-NANOMETER INFRARED SPECTROSCOPY AND IMAGING BASED ON A NEAR-FIELD PHOTOTHERMAL TECHNIQUE ("PTIR") -- 13.1 Introduction -- 13.2 AFMIR: Photothermal-Induced Resonance Experiment -- 13.3 Experimental Illustration of the Photothermal Technique -- 13.4 Applications: Biological Studies -- 13.5 Conclusion and Perspectives -- Acknowledgments -- References -- 14 FROM STUDY DESIGN TO DATA ANALYSIS -- 14.1 Aspects in the Design of Clinically Relevant Studies in Biomedical Vibrational Spectroscopy -- 14.2 The Role of Noise and Reproducibility in the Raw Spectra -- 14.3 Safeguarding the Analysis of Data and Its Interpretation -- 14.4 Conclusion -- Acknowledgments -- References -- 15 INTERPRETING SEVERAL TYPES OF MEASUREMENTS IN BIOSCIENCE -- 15.1 Introduction to the Analysis of Several Data Sets -- 15.2 Principal Component Analysis of One Data Table -- 15.3 Simultaneous Analysis of Two Data Blocks by Partial Least-Squares Regression (PLSR) -- 15.4 Simultaneous Analysis of Several Data Blocks by Multiblock PCA -- 15.5 Alternative Multiblock Methods -- References -- 16 INTERPLAY OF UNIVARIATE AND MULTIVARIATE ANALYSIS IN VIBRATIONAL MICROSCOPIC IMAGING OF MINERALIZED TISSUE AND SKIN -- 16.1 Introduction -- 16.2 IR Microscopic Characterization of an Unusual Form of Osteoporosis -- 16.3 Applications to the Epidermis -- 16.4 Concluding Remarks
Acknowledgments -- References -- INDEX
This comprehensive overview of biomedical applications of vibrational spectroscopy focuses on methodologies that are most relevant to biodiagnostics. After a few introductory chapters that summarize the current status of the field, the reference covers current spectroscopic applications; new spectroscopic directions; and study design and the analysis of vibrational spectral fingerprints from complex biological and clinical samples . With chapters contributed by leading international experts, Biomedical Vibrational Spectroscopy is a core resource
Description based on publisher supplied metadata and other sources
Electronic reproduction. Ann Arbor, Michigan : ProQuest Ebook Central, 2020. Available via World Wide Web. Access may be limited to ProQuest Ebook Central affiliated libraries
Link Print version: Lasch, Peter Biomedical Vibrational Spectroscopy Hoboken : John Wiley & Sons, Incorporated,c2008 9780470229453
Subject Diagnostic imaging.;Infrared spectroscopy.;Raman spectroscopy
Electronic books
Alt Author Kneipp, Janina
Celozzi, Salvatore
Janina, Kneipp
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