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Author Conrad, Cheryl D
Title The Handbook of Stress : Neuropsychological Effects on the Brain
Imprint Hoboken : John Wiley & Sons, Incorporated, 2011
book jacket
Edition 1st ed
Descript 1 online resource (1766 pages)
text txt rdacontent
computer c rdamedia
online resource cr rdacarrier
Series Blackwell Handbooks of Behavioral Neuroscience Ser. ; v.9
Blackwell Handbooks of Behavioral Neuroscience Ser
Note Cover -- Wiley-Blackwell Handbooks of Behavioral Neuroscience -- Title page -- Copyright page -- Dedication -- Contributors -- Foreword -- Preface -- Acknowledgments -- Abbreviations -- Part I: Basics of the Stress Response -- 1 The Basics of the Stress Response -- An Introduction to Stress -- The Road to Conceptualizing Stress -- Overview of Stress-response Physiology -- Overview of Key Stress Response Mediators -- Overview of the Stress Response Following Chronic Stress -- Emotional Response to Stress -- Stress and Cognition -- Neuroanatomy of Emotional Regulation -- Stress Pathology: Brain Structure and Function -- Stress Resilience: Genes, Endophenotype, and Neuropsychological Functioning -- Concluding Remarks -- 2 Central Nervous System Regulation of the Hypothalamic-Pituitary-Adrenal Axis Stress Response -- The Problem of Stress -- Acute Stress Responses -- Chronic Stress Responses -- Perspective: Stress, Chronic Stress, and Disease -- 3 Corticosteroid Receptor Involvement in the Stress Response -- Basal and Stress-induced Secretory Patterns -- Receptor and Action Patterns -- Brain MRs -- Brain GRs -- MR and GR Polymorphisms -- MR, GR, and CRH -- Future Directions -- Acknowledgment -- 4 Nongenomic Cellular Actions of Corticosteroids in the Brain -- Introduction -- Slow, Gene-mediated Effects of Glucocorticoids -- Rapid, Nongenomic Effects of Glucocorticoids -- Putative Mechanism of Action -- Concluding Remarks -- 5 Stress Effects on the Brain -- Introduction -- The Inter-relationship of Stress and Cognition -- NMDA Receptor-mediated Signaling and Neuroplasticity -- Epigenetic Mechanisms in Gene Transcription -- Emotional Challenges Result in Transcription-related Histone Modifications in the Brain -- The Dentate Gyrus Shows Sparse Epigenetic Responses -- Integration of Extracellular and Intracellular Pathways Signaling to the Chromatin
Significance of H3S10p/K14ac-associated Gene Expression in Dentate Gyrus Granule Neurons in Hippocampus-related Memory Formation -- Concluding Remarks -- 6 Mechanisms of Glucocorticoid Receptor Regulation of Gene Expression -- Introduction -- Mechanisms of Glucocorticoid-regulated Gene Expression -- Concluding Remarks -- Part II: Stress Influences on Brain Plasticity and Cognition -- 7 Stress and Adult Neurogenesis -- Adult Neurogenesis in the Dentate Gyrus -- Effects of Aversive Experience on Adult Neurogenesis -- Age, Species, and Sex Differences -- Stress Effects on Adult Neurogenesis: a Role for Glucocorticoids? -- A Role for Interleukin-1? -- Paradoxical Effects of Stress on Adult Neurogenesis -- Potential Functions of Adult Neurogenesis -- Summary -- 8 Neurobiological Basis of the Complex Effects of Stress on Memory and Synaptic Plasticity -- Progress in the Study of Stress, Memory, and Brain Function -- Stress Effects on Memory Consolidation and Retrieval -- Influence of Extrinsic and Intrinsic Stress on Memory -- Stress-induced Modulation of Synaptic Plasticity -- Stress, Memory, Synaptic Plasticity, and Corticosteroids -- Stress and Multiple Brain Memory Systems -- Temporal Dynamics Model of the Stress-induced Modulation of Memory -- Extending the Temporal Dynamics Model to Address Stress Effects on Retrieval -- Summary and Speculation on the Neural Basis of Traumatic Memory Processing -- Acknowledgment -- 9 Acute Glucocorticoids Interact with Arousal State in Regulating Long-term Memory Formation -- Introduction -- Acute Glucocorticoid Effects on Memory Consolidation -- Fast and Slow Glucocorticoid Actions -- Role of the Amygdala in Mediating Glucocorticoid Effects on Memory Consolidation -- Glucocorticoid Interactions with Noradrenergic Mechanisms in the BLA -- Rapid Glucocorticoid Interactions with Endocannabinoid Mechanisms
Concluding Remarks -- 10 Chronic Stress Effects on Corticolimbic Morphology -- Introduction -- Hippocampus -- Amygdala -- Striatum -- Prefrontal Cortex -- Mechanisms of Stress-induced Dendritic Remodeling -- Functional Implications of Stress-induced Dendritic Remodeling -- Future Directions -- 11 Effects of Chronic Stress on Memory and Neuroplasticity: Animal Studies -- Hippocampus-related Learning Processes: Spatial Learning -- Amygdala-related Learning: Fear Conditioning -- Learning Tasks Related to Prefrontal Cortical Function -- Individual Differences -- Latent Vulnerability to Stress across the Life span -- Stress Effects on Neuroplasticity Mediating the Behavioral Effects: a Focus on the Neural Cell Adhesion Molecule -- Conclusions -- 12 Stress and Glucocorticoid Effects on Learning and Memory -- History and Definitions of Stress -- The Stress Response: Catecholamines and Glucocorticoids -- Stress Methodology -- Emotions: an Important Modulator of Human Memory -- Acute Effects of GCs on Memory -- Is That the End of the Story? -- Conclusion -- Part III: Stress Effects Across the Life Span -- 13 Adolescence and Stress -- Introduction -- Stages of Development -- Maturation of HPA Axis during the Juvenile to Adult Transition -- Stress and the Hippocampal Formation -- Stress and the PFC -- Conclusions -- 14 Effect of Early Environment and Separation Animal Models on Neurobiological Development -- Shaping Brain and Behavior Through Experience -- Behavioral Effects of Social Isolation Rearing in Rodents -- Neuroanatomical Correlates of Social Isolation-rearing -- Postweaning Social Isolation and Central Neurotransmitter Function -- Neuroendocrine Adaptations and Importance of Early-life Environment -- Neuropeptide Neuromodulation and Early Social Environment -- Other Paradigms involving Early-environment Manipulation -- Conclusions -- Acknowledgment
15 Clinical Implications of Childhood Stress -- Introduction -- Family Environment Stressors -- Emotion Regulation -- Common Family Stressors -- Stress Inoculation -- Methodological Considerations -- Future Research -- Concluding Comments -- 16 Chronic Stress and Hippocampus Vulnerability to Functional Changes and Health in the Adult -- Introduction -- Glucocorticoid Cascade Hypothesis and Recent Developments -- Investigating Hippocampal Structural Changes Beyond Neuronal Loss -- Hippocampal CA3 Dendritic Retraction: Consequences on Spatial Ability -- Model for Chronic Stress and CA3 Dendritic Retraction in Spatial Ability -- Hippocampal CA3 Dendritic Retraction: Consequences on Hippocampal Health -- Glucocorticoid Vulnerability Hypothesis and Implications -- Acknowledgment -- 17 Stress and Aging -- Introduction -- Neuroendocrine Mechanisms and Aging in Resilience and Vulnerability -- Role of Cellular Plasticity Mechanisms in Stress and Aging -- Potential Interventions that Might Increase Resilience to Stress and Aging: Caloric Restriction and Exercise -- Conclusions and Summary -- Part IV: Stress Involvement in Anxiety, Posttraumatic Stress Disorder, and Depression -- 18 Social Stress Effects on Defensive Behavior and Anxiety -- Introduction -- Resource Conflict as a Focal Feature of Social Stress -- Social Stress from the Lack of Social Interaction -- Defensive Behaviors and Anxiety -- Defensive Behaviors and Anxiety Measures Following Social Stress -- Social Stress and Glucocorticoids -- Summary -- 19 Stress and Animal Models of Posttraumatic Stress Disorder -- Animal Models of PTSD -- Selected CBC-based Studies -- Can PTSD Be Prevented? -- Conclusions -- 20 What Can Fear Conditioning Tell Us About Posttraumatic Stress Disorder? -- Introduction -- The Neurocircuitry of Fear Conditioning
Biochemical Pathways and Synaptic Changes Underlying Fear Learning -- Stress Hormones and Fear Conditioning -- Extinction and Reconsolidation of Conditioned Fear -- Conclusion -- 21 Stress and Glucocorticoid Effects on Memory -- Introduction -- Glucocorticoid Effects on Memory Consolidation -- Glucocorticoid Effects on Memory Retrieval -- Glucocorticoid Effects on Working Memory -- Modulatory Effects of Glucocorticoids on Emotional Memory: Implications for Anxiety Disorders -- Conclusion -- 22 Stress and Human Neuroimaging Studies -- Lasting Effects of Traumatic Stress on the Brain and Behavior -- Neural Circuits of Trauma-spectrum Disorders -- Changes in Brain Structure in PTSD -- Functional Neuroimaging Studies in PTSD -- Neuroreceptor Studies in PTSD -- Brain-imaging Findings in Other Trauma-spectrum Disorders -- Summary and Conclusions -- 23 Chronic Stress and Depression -- Introduction -- Acute Versus Chronic Stress -- Animal Models of Chronic Stress -- Brain Cells Under Stress -- Plasticity of the Mature Brain -- Neuroplasticity at the Level of Gene Transcription -- Sex-specific Differences in Reactions to Stress -- Plasticity of Astrocytes -- Conclusions -- 24 How Can Stress Alter Emotional Balance Through Its Interaction with the Serotonergic System? -- Introduction -- HPA Axis, Corticotropin-releasing Factor, and Corticosteroids -- The 5-HT System and 5-HT Receptors Involved in Anxiety and Depression -- Regulation of the Serotonergic System via the HPA Axis -- Beyond the HPA-5-HT Interactions: Stress-related Changes in Neurotrophic and Epigenetic Factors -- Overview -- 25 Stress, Prefrontal Cortex Asymmetry, and Depression -- Overview of Prefrontal Cortical Involvement in Stress and Depression -- Lateralization of Stress Regulatory Systems: Autonomic Function -- Asymmetric Regulation of Neuroendocrine Function
Brain-imaging Studies, Depression, and Laterality
The Handbook of Stress: Neuropsychological Effects on the Brain is an authoritative guide to the effects of stress on brain health, with a collection of articles that reflect the most recent findings in the field. Presents cutting edge findings on the effects of stress on brain health Examines stress influences on brain plasticity across the lifespan, including links to anxiety, PTSD, and clinical depression Features contributions by internationally recognized experts in the field of brain health Serves as an essential reference guide for scholars and advanced students
Description based on publisher supplied metadata and other sources
Electronic reproduction. Ann Arbor, Michigan : ProQuest Ebook Central, 2020. Available via World Wide Web. Access may be limited to ProQuest Ebook Central affiliated libraries
Link Print version: Conrad, Cheryl D. The Handbook of Stress : Neuropsychological Effects on the Brain Hoboken : John Wiley & Sons, Incorporated,c2011 9781444330236
Subject Anxiety disorders.;Brain.;Neuropsychiatry.;Stress (Psychology)
Electronic books
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