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Author Alvarez-Buylla Roces, Maria Elena, author
Title Modeling methods for medical systems biology : regulatory dynamics underlying the emergence of disease processes / by Maria Elena Alvarez-Buylla Roces, Juan Carlos Martinez-Garcia, Jose Davila-Velderrain, Elisa Dominguez-Huttinger, Mariana Esther Martinez-Sanchez
Imprint Cham : Springer International Publishing : Imprint: Springer, 2018
book jacket
Descript 1 online resource (xxi, 258 pages) : illustrations, digital ; 24 cm
text txt rdacontent
computer c rdamedia
online resource cr rdacarrier
text file PDF rda
Series Advances in experimental medicine and biology, 0065-2598 ; volume 1069
Advances in experimental medicine and biology ; volume 1069
Note Introduction -- Medical systems biology -- Modeling procedures -- Case of study -- Conclusions and Perspectives -- Bibliography
This book contributes to better understand how lifestyle modulations can effectively halt the emergence and progression of human diseases. The book will allow the reader to gain a better understanding of the mechanisms by which the environment interferes with the bio-molecular regulatory processes underlying the emergence and progression of complex diseases, such as cancer. Focusing on key and early cellular bio-molecular events giving rise to the emergence of degenerative chronic disease, it builds on previous experience on the development of multi-cellular organisms, to propose a mathematical and computer based framework that allows the reader to analyze the complex interplay between bio-molecular processes and the (micro)-environment from an integrative, mechanistic, quantitative and dynamical perspective. Taking the wealth of empirical evidence that exists it will show how to build and analyze models of core regulatory networks involved in the emergence and progression of chronic degenerative diseases, using a bottom-up approach
Host Item Springer eBooks
Subject Biological models
Systems biology
Gene regulatory networks -- Physiology
Cell physiology
Chronic diseases
Morphogenesis
Life Sciences
Systems Biology
Microbial Genetics and Genomics
Mathematical Modeling and Industrial Mathematics
Computational Biology/Bioinformatics
Alt Author Martinez-Garcia, Juan Carlos, author
Davila-Velderrain, Jose, author
Dominguez-Huttinger, Elisa, author
Martinez-Sanchez, Mariana Esther, author
SpringerLink (Online service)
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