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Author Ehlert, Frederick J
Title Affinity and efficacy [electronic resource] : the components of drug-receptor interactions / Frederick J. Ehlert
Imprint New Jersey : World Scientific, 2014
book jacket
Descript 1 online resource
Note Includes bibliographical references
Ligand-gated ion channels -- Affinity and efficacy of orthosteric ligands at ligand-gated ion channels -- Competitive interactions between orthostheric ligands at ligand-gated ion channels -- Analysis of allosteric interactions at ligand-gated ion channels -- G protein-coupled receptors and G protein signaling -- Affinity and efficacy of the agonist-receptor-G-protein interaction -- Estimating affinity and efficacy by reverse-engineering and response-clamp analysis -- Analysis of agonism and inverse agonism in signaling pathways that exhibit constitutive activity -- Analysis of ligand bias in receptor signaling through different G protein pathways -- Competitive interactions between orthosteric ligands in functional assays on G protein-coupled receptors -- Analysis of allosterism in functional assays on G protein-coupled receptors -- Analysis of drug-receptor interactions using radioligand binding assays on G protein-coupled receptors
Print version record
Subject Drug receptors
Drugs -- Effectiveness
Drug-nutrient interactions
Pharmaceutical chemistry
Receptors, Drug
Ligand-Gated Ion Channels
Protein Binding
Radioligand Assay
Receptors, G-Protein-Coupled
Alt Title Components of drug-receptor interactions
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