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100 1  Kaufman, George Karl 
245 10 Electrostatic self-assembly of meso-scale structures 
300    349 p 
500    Source: Dissertation Abstracts International, Volume: 69-
       10, Section: B, page: 6125 
500    Adviser: George M. Whitesides 
502    Thesis (Ph.D.)--Harvard University, 2008 
520    This dissertation describes the electrostatic self-
       assembly of charged, meso-scale components (objects having
       dimensions on the order of millimeters) into ordered two-
       dimensional (2D) structures. Meso-scale components are 
       easy to fabricate, manipulate by hand, and visualize by 
       eye. Systems of meso-scale components embody some aspects 
       of molecular systems (e.g., electrostatic interactions), 
       and therefore serve as simple, physical models that 
       provide qualitative insight about molecular systems that 
       assemble (Appendices III--VIII) 
520    Electrostatic self-assembly is the process by which 
       electrets---materials with a permanent electric field at 
       their surface---form ordered structures. Charged, 
       monopolar spheres (Chapter 2) and dipolar particles 
       (Chapter 3) form 2D Coulombic crystals, which separate 
       from uncharged, polarizable particles. These systems model
       the nucleation of crystals of polar molecules in a 
       polarizable solvent. Appendix I describes the assembly of 
       charged spheres that are threaded on a string---a system 
       designed to model the folding of polymers. The materials 
       in each of these studies charge by contact electrification
       (Appendix II), the process by which materials transfer 
       charge when their surfaces contact each other 
520    Self-assembled monolayers (SAMs) comprise a single layer 
       of molecules that bind (covalently or non-covalently) to 
       surfaces. SAMs can modify the chemical properties of 
       surfaces and they may prove useful for incorporation into 
       molecular electronic devices. The roughness of the surface
       affects the structure and electrical characteristics of 
       the SAM. Part II of this dissertation describes the 
       formation (Appendix III) and the structural and electrical
       characterization (Appendix IV) of well-ordered SAMs on 
       ultraflat (template-stripped) surfaces 
520    Appendices V--VIII describe the binding and self-assembly 
       of proteins with small molecules (ligands and haptens). 
       Appendix V reviews extensively the binding of monovalent 
       and multivalent ligands to Carbonic Anhydrase. The binding
       of bivalent haptens to a monoclonal IgG antibody causes 
       the antibody to form clusters that contain two or three 
       antibody molecules (Appendix VII). This work is useful for
       purifying bivalent antibodies from a complex mixture of 
       proteins (Appendix VI). Charged proteins can be---in some 
       sense---classified as electrets; the acetylation of alpha-
       amylase produces highly negatively charged variants of the
       enzyme that resist aggregation and inactivation by anionic
       surfactants (Appendix VIII) 
590    School code: 0084 
650  4 Chemistry, Physical 
650  4 Physics, Electricity and Magnetism 
650  4 Biophysics, General 
690    0494 
690    0607 
690    0786 
710 2  Harvard University 
773 0  |tDissertation Abstracts International|g69-10B 
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