LEADER 00000nam  2200337   4500 
001    AAI1473721 
005    20101018150414.5 
008    101018s2010                        eng d 
020    9781109585650 
035    (UMI)AAI1473721 
040    UMI|cUMI 
100 1  Keller, Elizabeth Greer 
245 10 Novel chemotherapeutics against lung and colon cancer 
300    70 p 
500    Source: Masters Abstracts International, Volume: 48-03, 
       page: 1649 
500    Advisers: Christine Martey-Ochola; Barry Selinsky 
502    Thesis (M.S.)--Villanova University, 2010 
520    Lung cancer is well known as the second most common 
       malignancy and the leading cause of cancer related deaths 
       in the US for both men and women.1 Colon cancer is the 
       third most common type of cancer and the second leading 
       cause of cancer related deaths in the US.2, 3 There is a 
       constant quest for an optimal therapeutic drug for not 
       only these but all cancers. This research has focused on 
       screening novel compounds which include, but are not 
       limited to, pyrido-mimetics and purino-mimetics in an 
       attempt to delineate a new family of cancer fighting 
       drugs. The A549 epithelial lung and LS180 colon cancer 
       cell lines were used to determine the growth inhibitory 
       concentration of the drugs. These studies revealed two 
       lead compounds that were highly effective against both 
       cancers. The lowest IC50 values were noted in the 
       micromolar range similar to cisplatin, which is a widely 
       used chemotherapeutic agent. Compounds 4 and 8 were most 
       effective against the A-549 cells with IC-50 values of 
       59.15muM and 109.75muM respectively, and compounds 5 and 6
       were most effective against the LS-180 cells with IC-50 
       values of 175.4muM and 98.2 muM respectively. The most 
       effective compounds were tested to determine the mode of 
       action of both the A-549 and LS-180 cell lines. These 
       studies revealed that cell death primarily resulted from 
       damage or inhibition of the DNA, however the DNA itself 
       was unfragmented, which implies that these compounds 
       affect transcription or translation 
590    School code: 0245 
650  4 Chemistry, Biochemistry 
690    0487 
710 2  Villanova University.|bChemistry 
773 0  |tMasters Abstracts International|g48-03 
856 40 |uhttp://pqdd.sinica.edu.tw/twdaoapp/servlet/
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