LEADER 00000nam a2200505 i 4500 
001    978-981-10-2113-8 
003    DE-He213 
005    20161221083443.0 
006    m     o  d         
007    cr nn 008maaau 
008    161221s2016    si      s         0 eng d 
020    9789811021138|q(electronic bk.) 
020    9789811021121|q(paper) 
024 7  10.1007/978-981-10-2113-8|2doi 
040    GP|cGP|erda 
041 0  eng 
050  4 RC606.7 
082 04 615.7924|223 
245 00 Pharmacokinetic and pharmacodynamic drug interactions 
       associated with antiretroviral drugs /|cedited by Tony 
       K.L. Kiang, Kyle John Wilby, Mary H.H. Ensom 
264  1 Singapore :|bSpringer Singapore :|bImprint: Adis,|c2016 
300    1 online resource (vii, 135 pages) :|billustrations, 
       digital ;|c24 cm 
336    text|btxt|2rdacontent 
337    computer|bc|2rdamedia 
338    online resource|bcr|2rdacarrier 
347    text file|bPDF|2rda 
505 0  1. Introduction -- 2. HIV-Associated Comorbidities -- 3. 
       Pharmacology and Pharmacokinetic Properties of Available 
       Antiretrovirals -- 4. In Vitro Reaction Phenotyping and 
       Drug Interaction Data -- 5. Clinical Drug-Drug Interaction
       Data: Effects of Co-administered Drugs on Pharmacokinetics
       of Antiretroviral Agents -- 6. Clinical Drug-Drug 
       Interaction Data: Effects of Antiretroviral Agents on Co-
       administered Drugs -- 7. Pharmacodynamic Interactions 
       Between Antiretrovirals and Other Agents -- 8. Conclusion 
       and Clinical Decision Algorithm 
520    Clinically-focussed, with easily accessible tables and 
       chapter summaries suitable for clinicians and researchers,
       this comprehensive book provides a systematic, critical 
       evaluation of the current literature. An updated clinical 
       decision-making algorithm specifically tailored to the 
       antiretroviral drugs is also provided. The identified 
       interactions are interpreted in the context of known 
       mechanisms derived from clinical, preclinical, and in 
       vitro data. The clinical relevance of the interactions is 
       systematically evaluated and gaps in literature discussed 
       in the context of potential future experiments. In 
       addition to the comprehensive summary of pharmacokinetic 
       and pharmacodynamic drug interactions associated with WHO-
       recommended antiretroviral drugs on the market today (i.e.
       nucleotide reverse-transcriptase inhibitors, non-
       nucleoside reverse-transcriptase inhibitors, integrase 
       inhibitors, and protease inhibitors), this book also 
       provides detailed section summaries on the epidemiology of
       HIV infection, diagnosis and pharmacotherapy, basic 
       pharmacology of the individual antiretrovirals, pertinent 
       pre-clinical and in vitro molecular pharmacology, and in 
       vitro drug interaction data available in the literature 
       today 
650  0 Antiretroviral agents 
650  0 Pharmacokinetics 
650  0 Medicine 
650  0 Pharmacology 
650  0 Infectious diseases 
650 14 Biomedicine 
650 24 Pharmacology/Toxicology 
650 24 Infectious Diseases 
700 1  Kiang, Tony K.L.,|eeditor 
700 1  Wilby, Kyle John.,|eeditor 
700 1  Ensom, Mary H.H.,|eeditor 
710 2  SpringerLink (Online service) 
773 0  |tSpringer eBooks 
856 40 |uhttp://dx.doi.org/10.1007/978-981-10-2113-8