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Author Laycock, John Francis
Title Perspectives On Vasopressin
Imprint Singapore : World Scientific Publishing Company, 2009
©2009
book jacket
Descript 1 online resource (357 pages)
text txt rdacontent
computer c rdamedia
online resource cr rdacarrier
Note Intro -- Contents -- Preface -- Chapter 1. Introduction to Vasopressin (John Laycock) -- 1. Brief Historical Perspective -- 2. General Development, Anatomy and Structure of the Neurohypophysial System -- 3. Synthesis, Storage and Release of Neurohypophysial Hormones -- 4. Vasopressin Assays -- 5. Physiological Actions -- 6. Receptors and Mechanisms of Action -- 7. Circulation and Metabolism -- 8. Control of Release of Vasopressin -- 9. Clinical Aspects of Vasopressin -- 10. Conclusion -- Bibliography -- Chapter 2. Comparative and Evolutionary Aspects of Vasopressin (Jacques Hanoune) -- 1. Introduction -- 2. Evolutionary Aspects of the Vasopressin Family -- 3. Evolutionary Aspects of the Vasopressin Receptor Family -- 4. Evolutionary Aspects of the Aquaporin Family -- 5. Conclusion -- Bibliography -- Chapter 3. The Neurohypophysial System: Synthesis and Metabolism of Vasopressin (Jacques Hanoune) -- 1. Developmental Aspects of the Endocrine Hypothalamus -- 2. Biosynthesis -- a) Gene structure -- b) Processing of the mature peptide -- 3. Control of Vasopressin Secretion -- a) Control by extracellular osmolality and volaemia -- b) Additional factors -- 4. Extra-hypothalamic Expression of Vasopressin -- a) Adrenal medulla -- b) Testis -- c) Blood vessels and heart -- d) Other organs -- 5. Peripheral Degradation and Metabolic Clearance -- Bibliography -- Chapter 4. Vasopressin Receptors, the Signalling Cascade and Mechanisms of Action (Jacques Hanoune) -- 1. Introduction: A Short Historical Survey of Vasopressin Receptors -- 2. Pharmacological Characterization of the Vasopressin Receptors -- 3. Biochemical Characterization of the Vasopressin Receptors -- 4. Tissue Expression -- a) V1a receptor -- b) V1b (V3) receptor -- c) V2 receptor -- 5. Vasopressin Receptors and G Proteins: An Overview -- 6. Structure of the Vasopressin Receptors
a) General features -- b) Modelling of vasopressin receptors -- 7. Structural Basis of the Receptor-Ligand Interaction -- a) Binding of agonists -- b) Binding of antagonists -- 8. Domains Responsible for G Protein-Coupling Selectivity -- 9. Dimerization of Receptors -- 10. Signalling Pathways -- a) The heterotrimeric G protein -- b) The cyclic AMP pathway -- c) The calcium/phosphatidyl inositol pathway -- d) The V2 receptor pathway -- e) The V1a receptor pathway -- f ) The V1b receptor pathway -- g) The proteomic approach -- 11. Pre- and Post-transcriptional Regulation of Vasopressin Receptor Expression -- 12. Downregulation of Vasopressin Receptors: Desensitization and Internalization -- 13. Are There Other Vasopressin Receptors? -- Bibliography -- Chapter 5. Pharmacology of the Vasopressin Receptors (Jacques Hanoune) -- 1. Introduction -- 2. Radio-labelled Ligands -- 3. Pharmacology of the Vasopressin V1a Receptor -- 4. Pharmacology of the Vasopressin V1b Receptor -- 5. Pharmacology of the Vasopressin V2 Receptor -- 6. Mixed Vasopressin V1a/V2 Receptor Antagonists -- 7. Inter-species and Inter-organ Variability -- 8. Conclusion -- Bibliography -- Chapter 6. Vasopressin and Its Renal Effects (John Laycock) -- 1. Introduction -- 2. The Kidneys -- 3. The Renal Actions of Vasopressin -- a) Glomerular filtration and renal blood flow -- b) Vasopressin and the proximal tubule -- c) Vasopressin and the loop of Henle -- d) Vasopressin and the distal convoluted tubule -- e) Vasopressin and the collecting duct -- 4. Conclusion -- Bibliography -- Chapter 7. Vasopressin and the Cardiovascular System (John Laycock) -- 1. Introduction -- 2. Vasopressin and Its Vasoconstrictor Effect -- 3. Compensatory Mechanisms -- a) The central nervous system -- b) Cellular mechanisms -- 4. V2 Receptor-Mediated Vasodilatory Effect -- 5. Direct Cardiac Effects
a) Coronary vasoconstriction -- b) Cardiomyocyte contraction -- c) Cardiomyocyte growth and proliferation (mitogenesis and hypertrophy) -- 6. Central Cardiovascular Effects -- 7. Cardiovascular Interactions with Other Hormones -- 8. Vasopressin, the Kidneys and Arterial Blood Pressure -- 9. Vasopressin and Cardiovascular Development -- 10. Vasopressin and Haemostasis -- 11. Vassopressin and Hypertension -- 12. Conclusion -- Bibliography -- Chapter 8. Vasopressin and Its Interactions with Other Hormones and Control Systems (John Laycock) -- 1. Introduction -- 2. Vasopressin Interactions -- a) The renin-angiotensin system -- b) Prostaglandins -- c) Nitric oxide -- d) Oxytocin -- e) Natriuretic peptides -- f ) Adrenomedullin -- g) Catecholamines and the sympathetic nervous system -- h) Gonadal steroids -- i) The hypothalamo-pituitary-adrenal axis -- j) The hypothalamo-pituitary-thyroid axis -- k) Other anterior pituitary hormones -- 3. Conclusion -- Bibliography -- Chapter 9. Understanding the Role of Vasopressin in the Hypothalamo-Pituitary Adrenocortical Axis (Julia Buckingham) -- 1. Introduction -- 2. Historical Perspectives -- 3. Localisation and Regulation of Vasopressin in the Hypothalamo-Pituitary-Adrenal Axis -- 4. Mechanism of Vasopressin Action in the Pituitary Gland -- 5. Clinical Implications -- 6. Conclusion -- Bibliography -- Chapter 10. Vasopressin: The Central Systems (Gareth Leng and Simone Meddle) -- 1. Introduction -- 2. Peptide Signalling in the Brain -- 3. Evolution of Vasopressin Systems -- 4. Behavioural Effects in Mammals -- 5. Chemical Coding in Neural Networks: Early Evidence of Complexity -- 6. Behavioural Effects of Vasopressin: History of the Idea -- 7. Vasopressin's Diverse Central Actions -- 8. Sources of Vasopressin in the Brain -- 9. Sex Differences in the Vasopressin System -- 10. Central Actions of Vasopressin
a) Vasopressin cardiovascular regulation -- b) Vasopressin in thermoregulation -- c) Vasopressin stress responses, anxiety and depression -- d) Vasopressin in social behaviours -- e) Vasopressin in learning and memory -- 11. Parvocellular Vasopressin Cells of the Paraventricular Nucleus -- 12. The Suprachiasmatic Nucleus -- 13. The Magnocellular Vasopressin System -- 14. Dendritic Localization of Peptides -- 15. Vasopressin as an Autoregulator of Vasopressin Cell Activity -- 16. Conclusion -- Bibliography -- Chapter 11. Vasopressin Secretion: Mechanisms of Control of Secretion from the Posterior Pituitary Gland (Gareth Leng) -- 1. Introduction -- 2. Synthesis and Storage of Vasopressin -- 3. The Magnocellular Vasopressin Neurons -- 4. Regulation of Vasopressin Secretion -- 5. Stimulus-Secretion Coupling in the Neural Lobe -- 6. Vasopressin as an Autoregulator of Vasopressin Cell Activity -- 7. Phasic Firing -- 8. Physiological Significance of Phasic Firing -- 9. Diabetes Insipidus: The Consequences of Failure of Vasopressin Release -- Bibliography -- Chapter 12. Clinical Aspects of Vasopressin (Jacques Hanoune and John Laycock) -- 1. Introduction -- 2. Renal Disorders -- a) Central (hypothalamic) diabetes insipidus -- b) Nephrogenic diabetes insipidus -- c) Syndrome of inappropriate vasopressin secretion -- 3. Hyponatraemic Disorders -- a) Congestive heart failure and other oedematous, hyponatraemic states -- 4. Essential Hypertension -- 5. Haemolytic Disorders -- a) von Willebrand's disease -- b) Mild haemophilia A -- c) Other bleeding disorders -- 6. Conclusion -- Bibliography -- Index
Vasopressin is a hormone which has an increasingly important profile. Not only does it play a physiologically significant role in renal water regulation but it also has other renal actions and plays a role in overall cardiovascular control. Even more interesting is the recent growing interest in its potential effects on the brain, notably its influence on specific behaviours. This monograph about the polypeptide vasopressin covers all aspects relating to the production, control of release, and actions of this molecule within the body, including its roles as a hormone and as a central neurotransmitter. A consideration of the evolution of the molecule across the species and a brief historical perspective are also included. Clinical conditions associated with hypo- and hyper-production states are considered together with aspects of treatment, in addition to other clinical correlates. Sample Chapter(s). Chapter 1: Introduction to Vasopressin (204 KB). Contents: Introduction to Vasopressin; Comparative and Evolutionary Aspects of Vasopressin; The Neurohypophysial System: Synthesis and Metabolism of Vasopressin; Vasopressin Receptors, the Signalling Cascade and Mechanisms of Action; Pharmacology of the Vasopressin Receptors; Vasopressin and Its Renal Effects; Vasopressin and the Cardiovascular System; Vasopressin and Its Interactions with Other Hormones and Control Systems; Understanding the Role of Vasopressin in the Hypothalamo-Pituitary Adrenocortical Axis; Vasopressin: The Central Systems; Vasopressin Secretion: Mechanisms of Control of Secretion from the Posterior Pituitary Gland; Clinical Aspects of Vasopressin. Readership: Academics, researchers, and postgraduates in the field of endocrinology
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Electronic reproduction. Ann Arbor, Michigan : ProQuest Ebook Central, 2020. Available via World Wide Web. Access may be limited to ProQuest Ebook Central affiliated libraries
Link Print version: Laycock, John Francis Perspectives On Vasopressin Singapore : World Scientific Publishing Company,c2009 9781848162945
Subject Vasopressin.;Vasopressin -- Physiological effect
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