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Author Consuelas, Victoria A
Title Actin : Structure, Functions, and Disease
Imprint Hauppauge : Nova Science Publishers, Incorporated, 2012
book jacket
Descript 1 online resource (311 pages)
text txt rdacontent
computer c rdamedia
online resource cr rdacarrier
Series Protein Biochemistry, Synthesis, Structure and Cellular Functions
Protein Biochemistry, Synthesis, Structure and Cellular Functions
Note Intro -- ACTIN: STRUCTURE, FUNCTIONS AND DISEASE -- ACTIN: STRUCTURE, FUNCTIONS AND DISEASE -- Contents -- Preface -- Actin Dynamics and Remodeling of Cell-Cell Junctions in Epithelial Morphogenesis -- Abstract -- Introduction -- Actin Structure at Cell-Cell Junctions -- Cortical Actin Ring Structures in Epithelial Cells -- Medial Actin Networks Associated with Cell-Cell Junctions -- Actin Dynamics and Contractility in Cell-Cell Junction Remodleing -- Actin Dynamics in Establishment of Cell-Cell Adhesions -- Actin Dynamics in Disassembly of Cell-Cell Adhesions -- Actin Regulatory Proteins Driving Epithelial Morphogenesis in Cell Model Systems -- The Molecular Basis of Collective Cellular Behaviors: Cell-Cell Adhesion Systems and Their Actin-Membrane Connections -- Cadherin Adhesion Receptors -- Nectin Adhesion Receptors -- Tetraspanin Adhesion Receptors -- The Tight Junction Adhesion System -- Regulation of Actin-Membrane Connections during Epithelial Morphogenesis -- Rho Gtpases as Central Players in Local Control of Actin Dynamics and Cell-Cell Adhesion -- Epithelial Morphogenesis in Development: The Interface of Actin Dynamics, Cell-Cell Adhesion, and Cellular Signaling -- Detachment of Cell-Cell Adhesions and Dispersion of Cells from Dynamic Epithelial Tissues in Development -- Actin Dynamics That Drive Tissue Deformations - Furrows, Tubes and Vesicles -- Cellular Rearrangements within Epithelia - Convergent Extension by Intercalation -- Conclusion -- References -- Actin: Structure, Function and Disease -- Abstract -- Introduction -- Actin Structure -- Actin Monomers and Filaments -- Organization of Actin Filaments -- Actin Metabolism and Regulation -- Monomer-Binding Proteins -- Filament-Depolymerizing Proteins -- Filament End-Binding Proteins -- Filament Severing Proteins -- Cross-Linking Proteins -- Stabilizing Proteins
Motor Proteins -- Concluding Remarks -- Actin Function -- Structural Function -- Cell Morphology -- Plasma Membrane -- Actin and Signal Transduction -- Cell Tension -- Endocytosis -- Protrusions of Cell Membrane -- Cellular Adhesions -- Adherens Junctions -- Tight Junctions -- Cell-Cell Contact Formation -- Junction Stability -- Remodeling of Junctions -- Actin in Vascular Smooth Muscle -- Regulation of Actin in Vascular Smooth Muscle -- Actin at Synapses -- Dendritic Synapses -- Immunological Synapses -- Nuclear Structure -- Function in Motility -- Cellular Motility -- Membrane Deformation -- Fast Polymerization of Actin -- Adhesion Assembly and Disassembly -- Interaction Actin and Motor Proteins -- Muscle Cell Contraction -- Vesicle Transport -- Cytokinesis -- Regulation of Transcription and Gene Expression -- Chromatin-Remodeling -- Regulation of Gene Expression -- Actin and Transcription -- Actin in Pre-Mrnp -- Concluding Remarks -- Actin-Related Diseases -- Muscular Diseases -- Neurological Diseases -- Immunological Diseases -- Vascular Diseases -- Cancer -- Conclusion -- Acknowledgements -- References -- Osmotic Pressure: A Tool to Investigate the Polymeric Forms of Actin -- Abstract -- 1. Introduction -- 2. Methods -- 2.1. Measurement of the Macromolecular Osmotic Pressure -- 2.2. Determination of the Wet Weight of the Sample -- 2.3. Determination of the Dry Weight of the Sample -- 2.4. Determination of the Water Weight of the Sample -- 2.5. Determination of the Protein Weight -- 2.6. Special Care for Long Lasting Dialysis at Low Macromolecular Osmotic Pressures -- 2.6.1. The Dialysis of F-Actin -- 2.6.2. The Dialysis of F-Actin Against Poly(Ethylene Glycol) 40,000 Solutions -- 2.6.3. The Macromolecular Osmotic Pressure Induced by Poly(Ethylene Glycol) -- 3. Theory -- 3.1. Ideal and Non-Ideal Solutions
3.1.1. The Energetic of a Non-Ideal Solution -- 3.1.2. Solution of Two Macromolecular Solutes Undergoing Association, the Reaction Being at Chemical Equilibrium -- 3.2. The Relationship between the Chemical Potential of Water and the Chemical Potential of the Free Actin Monomer in F-Actin Solutions -- 3.3. Distribution and Energy of the Actin Filaments in the F-Actin Solution -- 3.4. Geometric Constraints -- 3.4.1. The Total Volume of the Hydrated Actin Filaments -- 3.4.2. The Total Volume of the Solution -- 3.4.3. The Average Interfilament Distance -- 3.4.4. The Orientation of the Monomers in the Actin Filament -- 3.5. The Mechanics of the Actin Filament -- 3.5.1. Stiffness, Compliance and Yield Strength -- 3.5.2. The Relation between Protein Osmotic Pressure and the Stiffness of the Actin Filament -- Nomenclature -- 4. Applications to Theory -- 4.1. The Actin Filament, the 'Fluttering Wing' Model -- 4.2. Comparison of the Osmotic Properties of F-Actin and of Tropomyosin-F-Actin -- 4.3. Osmotic Properties of the Calcium-Regulated Actin Filament -- 4.4. The Energetic of Solutions with 1. A Single Macromolecular Solute 2. Two Macromolecular Solutes Undergoing Association, the Reaction Being at Chemical Equilibrium -- 4.4.1. The Energetic of F-Actin Solutions -- 4.4.2. The Energetic of the Myosin Solutions -- 4.4.3. The Energetic of a Solution of Myosin and F-Actin, Equimolar as Monomers and at the Chemical Equilibrium -- 4.5. The Free Energy of the Free Actin Monomer and the Length Distribution of the Actin Filaments -- 4.5.1. Modeling the Length Distribution of the Actin Filaments as a Function of the Free Energy of the Free Actin Monomers -- Protein Osmotic Pressure Associated with F-Actin Solutions of Moderate Concentrations -- Equilibration of F-Actin Solutions against Poly(Ethylene Glycol) 40,000 Solutions The Macromolecular Osmotic Pressure and the Free Energy of the Actin Monomer -- Calculating the Actin Filament Length Distribution at the Steady State -- Filament Distribution Associated with theFree Energy Minimum of the Actin Filaments -- The Effect of the Dialysis against Poly(Ethylene Glycol) on the Length Distribution of the Actin Filaments -- 4.6. The Linear Relationship between Stiffness and Yield Strength Allows to Estimate the Yield Strength of Thin Filament In Vivo -- 4.7. Protein Osmotic Pressure and Cross-Bridge Attachment Determine the Stiffness of Thin Filaments in Muscle Ex Vivo -- 4.7.1. The Effect of Protein Osmotic Pressure on the Stiffness of Both Cross-Bridge and the Actin Filament -- 4.7.2. Possible Reasons for the Different Behavior of the Two Models -- 4.7.3. Putative Stiffness for the Fully Non-Overlapped Thin Filament -- 4.7.4. The Upper Limit of Thin Filament Stretching -- 4.7.5. The Energy Required to Stretch the Thin Filament -- Conclusions -- References -- Two Communication Bridges to One Versatile Molecule -- Abstract -- Integrins -- Classification of Integrins -- Integrin Structure -- Properties of Integrin Domains -- Recognition of RGD Sequences by Integrins -- Integrin-Associated Proteins -- Membrane Rafts in Supramolecular Complex Formation and Function -- Integrin Function and Signaling -- Identification and Cloning of DG -- DG Subdomains -- β-DG as an Outside-in Signal Transducer -- Functional DG Molecular Plasticity -- The Intriguing Location of β-DG at the Nuclei -- Involvement of β-DG in Dystrophies -- DG in Signaling Pathways -- β-DG and the Many Faces of Actin -- DG and Cancer -- DG and Integrins Share Some Functions and Activation Pathways -- References
Stressed Out and Actin Up: Stress-Activated Protein Kinase Regulation of Actin Remodeling Directs Endothelial Cell Morphology and Migration -- Abstract -- I. Introduction -- II. Fluid Shear Stress-Induced Changes in Endothelial Cell Morphology Result from Actin Reorganization -- a) Endothelial Cells Exposed to Low Fluid Shear Stress Do Not Remodel Their Actin Cytoskeleton to Align in the Direction of Flow -- b) High Fluid Shear Stress Induces Three-Phase Actin Remodeling -- c) Fluid Shear Stress Induces Nuclear Actin Formation -- III. Stress Activated Protein Kinases JNK and p38 Are Involved in Mechanotransduction of Fluid Shear Stress into Actin Adaptation -- a) Fluid Shear Stress Is Detected by Mechanosensors on Endothelial Cell Surfaces -- b) Stress Activated Protein Kinases JNK and p38 Mediate Fluid Shear Stress Mechanotransduction Events -- c) Actin Cytoskeleton Remodeling That Leads to Endothelial Cell Morphology Changes Is Mediated by Stress Kinase Activities -- JNK -- p38 -- IV. Actin Cytoskeleton-Induced Endothelial Barrier Function Is Mediated by Stress Kinase Activity -- V. Actin Cytoskeleton-Induced Endothelial Cell Migration Is Mediated by Stress Kinase Activity -- Conclusion -- Acknowledgements -- References -- The Molecular Mechanisms of Actin Regulatory Proteins -- Abstract -- Glossary -- Introduction -- Actin Nucleators: Sowing the Seeds of Actin -- NPFs: Kick Starting the ARP2/3 Machine -- Controlling the Controllers: Regulatory Mechanisms of the NPFs -- Distinct NPF Domains Are Important for Their Stability, Function and Cellular Localization -- Autoinhibition and Trans-Inhibition: An on/off Switch for the NPFs -- WASp and N-WASp Are Autoinhibited -- Trans-Inhibition: The WAVE and WASH Regulatory Complexes -- NPF Degradation Mechanisms- Control of NPF Stability -- NPFs and Cancer: The Actin-Metastasis-Invasion Connection
Description based on publisher supplied metadata and other sources
Electronic reproduction. Ann Arbor, Michigan : ProQuest Ebook Central, 2020. Available via World Wide Web. Access may be limited to ProQuest Ebook Central affiliated libraries
Link Print version: Consuelas, Victoria A. Actin: Structure, Functions and Disease Hauppauge : Nova Science Publishers, Incorporated,c2012 9781621001911
Subject Actins -- Physiology.;Actins -- Ultrastructure.;Tumors -- Pathophysiology.;Respiratory infections -- Pathophysiology
Electronic books
Alt Author Minas, Daniel J
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