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Author Angelo, Tamara
Title Chemical Drug Design
Imprint Berlin/Boston : De Gruyter, Inc., 2016
©2016
book jacket
Descript 1 online resource (298 pages)
text txt rdacontent
computer c rdamedia
online resource cr rdacarrier
Note Intro -- Preface -- Table of Contents -- List of Contributing Authors -- 1 Overview of chemical drug design -- 1.1 Drug design -- 1.2 Rational drug design -- 1.3 Ligand-based drug design -- 1.4 Structure-based drug design -- 1.5 Pharmacophore-based approaches -- 1.6 Structure-based approaches -- 1.7 New lead generation -- 1.8 Structure evaluation -- 1.9 Future directions -- 2 Drug designing in novel drug discovery: Trends, scope and relevance -- 2.1 Introduction -- 2.2 Drug designing -- 2.3 Applications of SBDD -- 2.4 Applications of LBDD -- 2.5 Role of cheminformatics in drug discovery -- 2.6 Conclusion -- 3 Structure- and ligand-based approaches in drug designing -- 3.1 Drug discovery -- 3.2 Drug design -- 3.3 Drug designing techniques -- 3.4 Quantitative Structure-Activity Relationship (QSAR) -- 3.5 Physicochemical parameters -- 3.6 Biological parameters -- 3.7 Statistical terms in QSAR -- 4 Drug design applied to natural products against neglected diseases -- 4.1 Natural products -- 4.2 Medicinal chemistry -- 4.3 Docking -- 4.4 Neglected diseases -- 4.5 Final considerations -- 5 Natural product hybrid compounds as drug leads -- 5.1 Introduction -- 5.2 Naturally occurring hybrids/conjugates of natural products -- 5.3 Synthetic hybrids of whole natural products -- 5.4 Conclusion -- 6 Drug metabolism -- 6.1 Introduction -- 6.2 Phase I Metabolic reactions -- 6.3 Oxidative mechanisms -- 6.4 Reductive reactions -- 6.5 Hydrolytic reactions -- 6.6 Phase II conjugation reactions -- 6.7 Factors affecting drug metabolism -- 7 Mistletoe lectin: A promising cancer therapeutic -- 7.1 Introduction -- 7.2 Anticancer potency of bacteria/plant lectins -- 7.3 Anticancer potency of mistletoe and the underlying mechanisms -- 7.4 Mistletoe lectins -- 7.5 Future directions -- 7.6 Concluding remarks -- 8 Antipsychotics -- 8.1 Introduction -- 8.2 History
8.3 Etiology of schizophrenia and related psychoses -- 8.4 Potential mechanism of action of antipsychotics -- 8.5 Structure-activity relationships and pharmacology of the drugs -- 8.6 Research into future treatments for schizophrenia and related psychoses -- 9 Chemometric analysis: A novel tool for herbal drug analysis and designing -- 9.1 Introduction -- 9.2 Experimental -- 9.3 Data analysis and quality evaluation -- 9.4 Results and discussion -- 9.5 Conclusion -- 10 Copper and its complexes: A pharmaceutical perspectives -- 10.1 Introduction -- 10.2 Source of dietetic copper -- 10.3 Recommended concentration of copper for human diet -- 10.4 Copper consumption and suggestions -- 10.5 Mechanism of copper transport in humans -- 10.6 Copper deficiency and symptoms -- 10.7 Copper metabolism and major diseases -- 10.8 Copper metabolism and hypothesized health problems -- 10.9 Copper complexes as an emerging tool in pharmaceutical sciences -- 10.10 Concluding remarks -- 11 Thiazole: A privileged scaffold in drug discovery -- 11.1 Introduction -- 11.2 Synthetic routes for the construction of the thiazole ring -- 11.3 Thiazole as privileged scaffold in synthetic drugs -- 11.4 Ritonavir -- 11.5 Nitazoxanide -- 11.6 Sulfathiazole -- 11.7 Thiabendazole -- 11.8 Fatostatin -- 11.9 Dasatinib -- 11.10 Tiazofurin -- 11.11 CYC116 -- 11.12 NCH-31 -- 11.13 TAK-715 -- 11.14 Meloxicam -- 11.15 Nizatidine -- 11.16 Famotidine -- 11.17 Conclusion -- Index
Description based on publisher supplied metadata and other sources
Electronic reproduction. Ann Arbor, Michigan : ProQuest Ebook Central, 2020. Available via World Wide Web. Access may be limited to ProQuest Ebook Central affiliated libraries
Link Print version: Angelo, Tamara Chemical Drug Design Berlin/Boston : De Gruyter, Inc.,c2016 9783110374490
Subject Drugs--Design
Electronic books
Alt Author Bhattacharyya, Rajasri
Kataria, Ramesh
Kumar, Sunil
Mathur, Garima
Mehta, S. K
Mendonça, Francisco J. B
Nain, Sumitra
Paliwal, Sarvesh
Patel, Seema
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