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Author Marder, Victor J
Title Hemostasis and Thrombosis : Basic Principles and Clinical Practice
Imprint Philadelphia : Wolters Kluwer, 2012
©2013
book jacket
Edition 6th ed
Descript 1 online resource (1590 pages)
text txt rdacontent
computer c rdamedia
online resource cr rdacarrier
Note Hemostasis and Thrombosis -- CONTRIBUTING AUTHORS -- PREFACE -- FROM THE PREFACE TO THE FIRST EDITION -- ACKNOWLEDGMENTS -- CONTENTS -- PART I Introduction to the Field of Hemostasis and Thrombosis -- The Field of Hemostasis and Thrombosis: Selected Translational Achievements -- Molecular Evolution of the Vertebrate Blood Coagulation System -- Molecular and Clinical Genetics -- Coagulation Enzymology -- Cell Biology, Protein Processing, and Cell Signaling -- Overview of the Immune System -- Biostatistics and Epidemiology: The Basic Science of Clinical Research -- PART II Basic Principles of Hemostasis and Thrombosis -- SECTION A COAGULATION AND FIBRINOLYSIS -- Overview of Basic Coagulation and Fibrinolysis -- The Blood Coagulation Factors and Inhibitors: Their Primary Structure, Complementary DNAs, Genes, and Expression -- Genetics of Coagulation -- Tissue Factor and the Initiation and Regulation (TFPI) of Coagulation -- Factor V and Factor VIII -- Structure and Function of von Willebrand Factor -- Structure and Function of Vitamin K-Dependent Coagulant and Anticoagulant Proteins -- Factor XI -- The Factor XII-Driven Plasma Contact System -- Fibrinogen Structure and Function -- Factor XIII -- Antithrombin and the Serpin Family -- Protein C, Protein S, Thrombomodulin, and the Endothelial Protein C Receptor Pathways -- Plasminogen Activation and Regulation of Fibrinolysis -- Inhibitors of Fibrinolysis -- SECTION B PLATELET BIOLOGY -- Overview of Megakaryocyte and Platelet Biology -- Platelet Production: Cellular and Molecular Regulation -- Megakaryocyte Structure and Platelet Biogenesis -- Thrombopoietin -- Major Platelet Glycoproteins: Platelet Glycoprotein Ib-IX-V -- Major Platelet Glycoproteins: INTEGRIN αIIbβ3 (GPIIb-IIIa) -- Platelet Glycoprotein Polymorphisms and Relationship to Function and Immunogenicity -- The Basis for Platelet Adhesion
Shear Effects on Platelets and the Vessel Wall in the Pathogenesis of Atherothrombosis -- Platelet Collagen Receptors -- Integrin αIIbβ3 and Platelet Aggregation -- Molecular Basis for Platelet Secretion -- Platelet Signal Transduction -- Platelet Prostanoid Metabolism -- The Role of Platelets in Blood Coagulation -- Blood-Borne Microparticles -- SECTION C VASCULAR BIOLOGY -- Overview of Vascular Biology -- Development of the Vasculature, Angiogenesis, and Lymphangiogenesis -- Rheology and Vessel Wall Stress -- Nitric Oxide: The Vascular Biology of Nitric Oxide and Nitric Oxide Synthases -- Blood Vessel Wall in Health and Disease -- Endothelial Cell Function -- Role of the Endothelium in Hemostasis -- Coagulation-Independent Signaling of the Extrinsic Coagulation Pathway -- Heparin and Vascular Proteoglycans -- Endothelial Cell-Blood Cell Interactions -- Leukocyte Function and Contribution to Disease -- Laboratory Markers of Endothelial Cell Activation and Dysfunction -- PART III Disorders of Coagulation, Platelets, and Vessel Wall -- SECTION A BLEEDING DISORDERS OF COAGULATION AND FIBRINOLYSIS -- Overview of Inherited Hemorrhagic Disorders -- Differential Diagnosis of the Bleeding Patient -- Clinical Manifestations and Therapy of Inherited and Acquired Hemophilia -- SECTION B ACQUIRED AND INHERITED PLATELET DISORDERS -- Overview of Acquired and Inherited Clinical Platelet Disorders -- Differential Diagnosis of Thrombocytopenia -- Immune Thrombocytopenia and Posttransfusion Purpura -- Drug-Induced Thrombocytopenia -- Inherited Thrombocytopenias -- Acquired Nonimmune Thrombocytopenia -- Inherited Disorders of Platelet Function -- Acquired Disorders of Platelet Function -- Laboratory Markers of Platelet Activation -- SECTION C PRIMARY DISORDERS OF BLOOD VESSELS -- Overview of Primary Disorders of Blood Vessels
Disorders of Connective Tissue and Extracellular Matrix -- Hereditary Hemorrhagic Telangiectasia -- Arteriovenous Malformations and Hemangiomas and Cerebral Cavernous Malformations -- Aneurysms (Large and Small Arteries) -- Intracranial Hemorrhage and Subarachnoid Hemorrhage -- Retinopathy -- SECTION D THERAPY OF BLEEDING DISORDERS -- Overview of Therapy of Bleeding Disorders -- Management of Acute Hemorrhage -- Therapy with Antifibrinolytic Agents -- Platelets, Plasma, and Specialized Coagulation Concentrate Therapies -- New Approaches for the Therapy of Bleeding Disorders, Including Gene Therapy -- PART IV: THROMBOTIC DISORDERS -- SECTION A VENOUS THROMBOTIC DISORDERS -- Overview of Venous Thromboembolism -- Thrombophilia Genetics -- Epidemiology and Risk Factors for Venous Thromboembolism -- Clinical Manifestations and Diagnosis of Venous Thromboembolism -- Venous Thrombosis in Unusual Sites -- Sequelae of Venous Thromboembolic Disease: Postthrombotic Syndrome and Chronic Thromboembolic Pulmonary Hypertension -- Prevention of Venous Thromboembolic Disease -- Treatment of Venous Thromboembolic Disease -- SECTION B ARTERIAL THROMBOTIC DISORDERS -- Overview of Arterial Thrombotic Disorders -- Pathophysiology of Atherothrombosis -- Acute Coronary Syndromes: Manifestations and Management -- Pathophysiology of Thromboembolic Stroke -- Prevention of Thromboembolic Stroke in Patients with Atrial Fibrillation, Valvular Heart Disease, or Cardiomyopathy -- Ischemic Stroke: Acute Thrombolytic Therapy, Antithrombotic Approaches, and General Management -- Medical and Surgical Treatment of Peripheral Arterial Disease -- Unusual Sites of Arterial Occlusion -- Pathogenesis and Treatment of Biomaterial-Associated Thrombosis -- SECTION C COMPLEX THROMBOTIC DISORDERS -- Overview of Complex Thrombohemorrhagic Disorders -- Consumptive Thrombohemorrhagic Disorders
The Thrombotic Thrombocytopenic Purpura and Hemolytic Uremic Syndromes -- Vasculitides -- The Antiphospholipid Syndrome -- Myeloproliferative Neoplasms and Thrombohemorrhagic Complications -- Thrombotic and Hemorrhagic Complications Associated with Stem Cell Transplantation -- SECTION D THERAPEUTIC AGENTS -- Overview of Therapeutic Agents Used in Thrombotic Disorders -- Pharmacology and Mode of Action of Heparin and Glycosaminoglycans -- Vitamin K Antagonists: Biochemistry, Pharmacology, and Management -- Hemorrhagic Complications of Anticoagulation -- Heparin-Induced Thrombocytopenia -- Coumarin-Induced Skin Necrosis and Venous Limb Gangrene -- New Antithrombotic Drugs -- Antiplatelet Therapy -- Foundations of Thrombolytic Therapy -- Anticoagulant and Procoagulant Proteins in the Animal Kingdom -- Mechanical Devices and Embolectomy -- PART V Hemostatic and Thrombotic Disorders Associated with Systemic Conditions -- Overview of Special Clinical Groups -- Venous Thromboembolism during Pregnancy and with Hormonal Contraceptives -- Gestational Vascular Complications -- Maternal Hemostatic Disorders and Obstetric Hemorrhage -- Developmental Hemostasis -- Bleeding in Neonates and Children -- Venous and Arterial Thromboembolism in Children -- Thrombotic Complications of Sickle Cell Disease -- Thrombohemorrhagic Complications of Sepsis -- Hemorrhagic Fevers: Epidemiology, Pathophysiology, and Clinical Features -- Cancer-Related Thrombosis -- Hemostatic Challenges in Liver Disease -- Hemostatic Abnormalities in Renal Disease -- Multitrauma Derangements in Hemostasis and Thrombosis -- Blood Management in the Cardiovascular Surgical Patient -- Thrombohemorrhagic Events in the Elderly: Special Considerations -- INDEX
Since publication of the First Edition in 1982, Hemostasis and Thrombosis has established itself as the pre-eminent book in the field of coagulation disorders. No other book is as inclusive in scope, with coverage of the field from the standpoint of both basic scientists and clinicians. This comprehensive resource details the essentials of bleeding and thrombotic disorders and the management of patients with these and related problems, and delivers the most up-to-date information on normal biochemistry and function of platelets or endothelial cells, as well as in-depth discussions of the pharmacology of anticoagulant, fibrinolytic, and hemostatic drugs. NEW to the Sixth Edition… A new team of editors, each a leader in his field, assures you of fresh, authoritative perspectives. Full color throughout A companion website that offers full text online and an image bank. A new introductory section of chapters on basic sciences as related to the field Entirely new section on Hemostatic and Thrombotic Disorders Associated with Systemic Conditions includes material on pediatric patients, women's health issues, cancer, sickle cell disease, and other groups. Overview chapters preceding each section address broad topics of general importance
Description based on publisher supplied metadata and other sources
Electronic reproduction. Ann Arbor, Michigan : ProQuest Ebook Central, 2020. Available via World Wide Web. Access may be limited to ProQuest Ebook Central affiliated libraries
Link Print version: Marder, Victor J. Hemostasis and Thrombosis : Basic Principles and Clinical Practice Philadelphia : Wolters Kluwer,c2012 9781608319060
Subject Hemorrhagic diseases.;Blood coagulation disorders.;Hemostasis.;Thrombosis
Electronic books
Alt Author Aird, William C
Bennett, Joel S
Schulman, Sam
Gilbert C. White, I. I
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